CONSOLIDATED STATEMENTS OF STOCKHOLERS' EQUITY - USD ($) $ in Thousands	Total	Cumulative Effect, Period of Adoption, Adjustment	Common Stock	Additional Paid-in Capital	Accumulated Deficit	Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment	Accumulated Other Comprehensive (Loss) Income	Non- Controlling Interest
Beginning Balances (in shares) at Dec. 31, 2018			102,187,471
Beginning Balances at Dec. 31, 2018	$ 367,257	$ 897	$ 1,022	$ 929,632	$ (562,696)	$ 897	$ (1,440)	$ 739
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax (in shares)			885,873
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax	$ 3,677		$ 9	3,668
Issuance of common stock under employee stock purchase plan (in shares)	249,364		249,364
Issuance of common stock under employee stock purchase plan	$ 2,044		$ 2	2,042
Issuance of common stock, net of issuance costs (in shares)			12,650,000
Issuance of common stock under public offering, net of issuance costs	136,308		$ 127	136,181
Stock-based compensation	19,330			19,330
Acquisition of additional shares of Sangamo France	(321)							(321)
Issuance costs related to Sangamo France acquisition	(25)			(25)				0
Foreign currency translation adjustment	(1,573)						(1,573)
Net pension losses	(28)						(28)
Net unrealized gain (loss) on marketable securities, net of tax	592						592
Buy-out of non-controlling interest	0
Net loss	(95,419)				(95,186)			(233)
Ending Balances (in shares) at Dec. 31, 2019			115,972,708
Ending Balances at Dec. 31, 2019	432,739		$ 1,160	1,090,828	(656,985)		(2,449)	185
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax (in shares)			1,395,956
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax	$ 8,559		$ 14	8,545
Issuance of common stock under employee stock purchase plan (in shares)	274,382		274,382
Issuance of common stock under employee stock purchase plan	$ 2,015		$ 3	2,012
Issuance of common stock, net of issuance costs (in shares)			24,420,157
Issuance of common stock under public offering, net of issuance costs	142,526		$ 244	142,282
Stock-based compensation	25,708			25,708
Acquisition of additional shares of Sangamo France	(927)							(927)
Foreign currency translation adjustment	8,345						8,345
Net pension losses	(193)						(193)
Net unrealized gain (loss) on marketable securities, net of tax	(284)						(284)
Buy-out of non-controlling interest	0
Net loss	$ (121,122)				(120,996)			(126)
Ending Balances (in shares) at Dec. 31, 2020	142,063,203		142,063,203
Ending Balances at Dec. 31, 2020	$ 497,366		$ 1,421	1,269,375	(777,981)		5,419	(868)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax (in shares)			1,417,288
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax	$ 2,389		$ 14	2,375
Issuance of common stock under employee stock purchase plan (in shares)	433,107		433,107
Issuance of common stock under employee stock purchase plan	$ 3,370		$ 4	3,366
Issuance of common stock, net of issuance costs (in shares)			2,007,932
Issuance of common stock under public offering, net of issuance costs	27,099		$ 20	27,079
Stock-based compensation	32,956			32,956
Acquisition of additional shares of Sangamo France	(134)			(70)				(64)
Foreign currency translation adjustment	(8,351)						(8,351)
Net pension losses	(716)						(716)
Net unrealized gain (loss) on marketable securities, net of tax	(339)						(339)
Buy-out of non-controlling interest	943			(943)				943
Net loss	$ (178,297)				(178,286)			(11)
Ending Balances (in shares) at Dec. 31, 2021	145,921,530		145,921,530
Ending Balances at Dec. 31, 2021	$ 375,343		$ 1,459	$ 1,334,138	$ (956,267)		$ (3,987)	$ 0