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Other Balance Sheet Details
 12 Months Ended
Dec. 31, 2020
Balance Sheet Related Disclosures [Abstract]  
Other Balance Sheet Details OTHER BALANCE SHEET DETAILS
Property and Equipment, Net
Property and equipment, net consist of the following (in thousands):
December 31,
20202019
Laboratory equipment$24,737 $17,179 
Furniture and fixtures4,870 4,639 
Leasehold improvements15,953 13,888 
Manufacturing equipment1,089 — 
Construction in progress12,091 5,901 
58,740 41,607 
Less: accumulated depreciation and amortization(17,416)(11,681)
Property and equipment, net$41,324 $29,926 
Depreciation and amortization expense was $5.7 million in 2020, $3.9 million in 2019 and $2.4 million in 2018.
Intangible Assets
The changes in intangible assets were as follows (in thousands):
December 31,
20202019
Balance at beginning of year$53,156 $54,243 
Foreign currency translation adjustment4,972 (1,087)
Balance at end of year$58,128 $53,156 
Goodwill
The changes in goodwill were as follows (in thousands):
December 31,
20202019
Balance at beginning of year$39,273 $40,044 
Foreign currency translation adjustment3,525 (771)
Balance at end of year$42,798 $39,273 
Other Accrued Liabilities
Other accrued liabilities consist of the following (in thousands):
December 31,
20202019
Customer advance$5,000 $— 
Accrued research and development expenses4,257 4,102 
Operating lease liabilities – current
3,690 3,214 
Accrued professional fees1,532 1,118 
Other4,133 2,451 
Total other accrued liabilities$18,612 $10,885