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Organization, Basis of Presentation and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Jan. 01, 2019
Organization And Summary Of Significant Accounting Policies [Line Items]            
Decrease in revenues $ (21,958) $ (23,562) $ (47,577) $ (57,615)    
Increase in net loss $ 27,361 $ 12,843 $ 99,920 $ 49,670    
Topic 842            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Cumulative-effect adjustment of ASC           $ 897
Pfizer | Customer Concentration Risk | Total revenues            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Percentage of revenues 16.00% 44.00% 11.00% 46.00%    
Kite Pharma Inc            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Decrease in revenues $ (8,861) $ (9,028) $ (26,233) $ (16,544)    
Kite Pharma Inc | Customer Concentration Risk | Total revenues            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Percentage of revenues 40.00% 38.00% 55.00% 29.00%    
Sanofi            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Decrease in revenues $ (2,754) $ (2,240) $ (7,763) $ (11,139)    
Sanofi | Customer Concentration Risk | Total revenues            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Percentage of revenues 40.00% 10.00% 29.00% 19.00%    
Change in Collaboration Agreement Scope | Collaboration Agreement | Pfizer            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Decrease in revenues     $ 3,000      
Increase in net loss     $ 3,000      
Increase in basic net loss per share (Usd per share)     $ 0.03      
Other non-current assets            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Reclassification adjustment         $ 600  
Accumulated Deficit            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Increase in net loss $ 27,307 $ 12,843 $ 99,741 $ 49,670    
Accumulated Deficit | Topic 842            
Organization And Summary Of Significant Accounting Policies [Line Items]            
Cumulative-effect adjustment of ASC           $ 897