Refer below for a summary of the amount by which each financial statement line item was affected by the impact of the cumulative adjustment and as compared with the guidance that was in effect prior to the adoption:

	Impact of Topic 606 Adoption on Condensed Consolidated Balance Sheet as of January 1, 2018
(in thousands)	As reported under Topic 606			Adjustments			Balances without adoption of Topic 606
Deferred revenue, current portion	$	29,626		$	1,281		$	28,345
Deferred revenue, noncurrent portion	$	26,846		$	(2,398	)	$	29,244
Accumulated deficit	$	(494,362	)	$	1,117		$	(495,479	)

	Impact of Topic 606 Adoption on Condensed Consolidated Balance Sheet as of June 30, 2018
(in thousands)	As reported under Topic 606			Adjustments			Balances without adoption of Topic 606
Deferred revenue, current portion	$	57,215		$	8,744		$	65,959
Deferred revenue, noncurrent portion	$	137,731		$	(3,581	)	$	134,151
Accumulated deficit	$	(531,189	)	$	(5,163	)	$	(536,352	)

	Impact of Topic 606 Adoption on Condensed Consolidated Statement of Operations and Comprehensive Loss for the Three Months Ended June 30, 2018									Impact of Topic 606 Adoption on Condensed Consolidated Statement of Operations and Comprehensive Loss for the Six Months Ended June 30, 2018
(in thousands)	As reported under Topic 606			Adjustments			Balances without adoption of Topic 606			As reported under Topic 606			Adjustments			Balances without adoption of Topic 606
Collaboration revenue	$	21,289		$	(2,271	)	$	19,018		$	33,840		$	(4,047	)	$	29,793
Net loss	$	(16,640	)	$	(2,271	)	$	(18,911	)	$	(36,827	)	$	(4,047	)	$	(40,874	)
Net loss per share - basic and diluted:	$	(0.17	)	$	(0.02	)	$	(0.19	)	$	(0.40	)	$	(0.04	)	$	(0.44	)

	Impact of Topic 606 Adoption on Condensed Consolidated Statement of Cash Flows for the Six Months Ended June 30, 2018
(in thousands)	As reported under Topic 606			Adjustments			Balances without adoption of Topic 606
Net loss	$	(36,827	)	$	(4,047	)	$	(40,874	)
Changes in deferred revenue	$	138,474		$	4,047		$	142,521