Major Customers, Partnerships and Strategic Alliances (Tables)

12 Months Ended

Dec. 31, 2017

Revenues recognized under the Bioverativ Agreement for the years ended December 31, 2017, 2016 and 2015 are as follows (in thousands):


	Year Ended December 31,
	2017		2016		2015
Revenue related to Bioverativ Collaboration:
Recognition of upfront fee	$	1,769	$	2,321	$	6,176
Research services		10,489		6,565		7,769
Total	$	12,258	$	8,886	$	13,945

Revenues recognized under the Shire Agreement for the years ended December 31, 2017, 2016 and 2015, were as follows (in thousands):


	Year Ended December 31,
	2017		2016		2015
Revenue related to Shire Collaboration:
Recognition of upfront fee	$	2,333	$	2,181	$	2,167
Research services		116		1,096		13,584
Total	$	2,449	$	3,277	$	15,751

Revenues recognized under the agreement with Sigma for the years ended December 31, 2017, 2016 and 2015, were as follows (in thousands):


	Year Ended December 31,
	2017		2016		2015
Revenue related to Sigma Collaboration:
Royalty revenues	$	452	$	137	$	390
License fee revenues		267		1,140		4,463
Total	$	719	$	1,277	$	4,853