Intangible Assets - Additional Information (Detail) $ in Thousands	12 Months Ended
Dec. 31, 2015 USD ($) Candidate
Finite Lived Intangible Assets [Line Items]
Impairment charge	$ 1,870
Ceregene, Inc. [Member]
Finite Lived Intangible Assets [Line Items]
Number of clinical product candidates \| Candidate	2
Impairment charge	$ 1,870

Amount of impairment loss resulting from write-down of assets, excluding financial assets and goodwill, lacking physical substance and having a projected indefinite period of benefit to fair value.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 350
-SubTopic 30
-Section 50
-Paragraph 3
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=26713463&loc=d3e16373-109275

Name:	us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration