Cash equivalent maturity period highly liquid investment.

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- Definition

Minimum percentage of likelihood of indefinite lived intangible assets being impaired.

+ References

No definition available.

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- Definition

Organization and summary of significant accounting policies.

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- Definition

Share based compensation arrangement by share based payment award options and restricted stock units outstanding number.

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No definition available.

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- Definition

Amount of increase (decrease) in the value of a contingent consideration liability, including, but not limited to, differences arising upon settlement.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 30
-Section 50
-Paragraph 4
-Subparagraph (a)(1)
-URI http://asc.fasb.org/extlink&oid=35744584&loc=d3e7008-128479

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- Definition

For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 275
-SubTopic 10
-Section 50
-Paragraph 18
-URI http://asc.fasb.org/extlink&oid=51801978&loc=d3e6351-108592

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 20
-URI http://asc.fasb.org/extlink&oid=49121117&loc=d3e13531-108611

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 275
-SubTopic 10
-Section 50
-Paragraph 20
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Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 825
-SubTopic 10
-Section 50
-Paragraph 21
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=49121117&loc=d3e13537-108611

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- Definition

Amount of impairment loss resulting from write-down of assets, excluding financial assets and goodwill, lacking physical substance and having a projected indefinite period of benefit to fair value.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 350
-SubTopic 30
-Section 50
-Paragraph 3
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=26713463&loc=d3e16373-109275

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- Definition

Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues.

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- Definition

Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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No definition available.

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The carrying amounts of cash and cash equivalent items which are restricted as to withdrawal or usage. Restrictions may include legally restricted deposits held as compensating balances against short-term borrowing arrangements, contracts entered into with others, or entity statements of intention with regard to particular deposits; however, time deposits and short-term certificates of deposit are not generally included in legally restricted deposits. Excludes compensating balance arrangements that are not agreements which legally restrict the use of cash amounts shown on the balance sheet. For a classified balance sheet represents the current portion only (the noncurrent portion has a separate concept); there is a separate and distinct element for unclassified presentations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.1)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands	12 Months Ended
	Dec. 31, 2015 USD ($) Segments shares	Dec. 31, 2014 USD ($) shares	Dec. 31, 2013 USD ($) shares
Organization and Summary of Significant Accounting Policies [Line Items]
Liquid investments purchased with original maturities	three months or less
Restricted cash		$ 320
Percentage of likelihood of indefinite lived intangible assets being impaired	50.00%
Impairment charge	$ 1,870
Change in fair value of contingent liability	$ (1,800)	$ 230	$ 60
Stock options and restricted stock units outstanding \| shares	9,008,185	8,905,782	9,469,521
Number of operating segments \| Segments	1
Shire AG [Member] \| Customer Concentration Risk [Member] \| Total revenues [Member]
Organization and Summary of Significant Accounting Policies [Line Items]
Percentage of revenues	40.00%	57.00%	68.00%
Biogen Inc [Member] \| Customer Concentration Risk [Member] \| Total revenues [Member]
Organization and Summary of Significant Accounting Policies [Line Items]
Percentage of revenues	35.00%	28.00%
Sigma-Aldrich Corporation [Member] \| Customer Concentration Risk [Member] \| Total revenues [Member]
Organization and Summary of Significant Accounting Policies [Line Items]
Percentage of revenues			9.00%
Dow AgroSciences LLC [Member] \| Customer Concentration Risk [Member] \| Total revenues [Member]
Organization and Summary of Significant Accounting Policies [Line Items]
Percentage of revenues			12.00%
Minimum [Member]
Organization and Summary of Significant Accounting Policies [Line Items]
Estimated useful lives of related assets	3 years
Maximum [Member]
Organization and Summary of Significant Accounting Policies [Line Items]
Estimated useful lives of related assets	5 years