Major Customers, Partnerships and Strategic Alliances (Tables)

3 Months Ended

Mar. 31, 2015

Biogen Inc [Member]

Research and Development Arrangement, Contract to Perform for Others [Line Items]

Revenues Recognized under Agreement

Revenues recognized under the agreement with Biogen for the three months ended March 31, 2015 and 2014 are as follows (in thousands):

	Three months ended
	March 31,
	2015		2014
Revenue related to Biogen Collaboration:
Recognition of upfront fee	$	1,523	$	660
Research services		1,533		423
Total	$	3,056	$	1,083

Shire AG [Member]

Research and Development Arrangement, Contract to Perform for Others [Line Items]

Revenues Recognized under Agreement

Revenues recognized under the agreement with Shire for the three months ended March 31, 2015 and 2014, were as follows (in thousands):

	Three months ended
	March 31,
	2015		2014
Revenue related to Shire Collaboration:
Recognition of upfront fee	$	542	$	542
Research services		4,522		4,979
Total	$	5,064	$	5,521

Sigma-Aldrich Corporation [Member]

Research and Development Arrangement, Contract to Perform for Others [Line Items]

Revenues Recognized under Agreement

Revenues recognized under the agreement with Sigma for the three months ended March 31, 2015 and 2014, were as follows (in thousands):

	Three months ended
	March 31,
	2015		2014
Revenue related to Sigma Collaboration:
Royalty revenues	$	264	$	106
License fee revenues		4,256		179
Total	$	4,520	$	285