-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, Fp5Zpl/ucB9JQe7VZ6qLiXV6Jb6qoqiutMoVS8sZ+mrcNQfwEgJT9XBwyuQXwzYZ LtQJYu5XBQ6tZvz3QJaOPA== 0001275287-05-002266.txt : 20050621 0001275287-05-002266.hdr.sgml : 20050620 20050621080030 ACCESSION NUMBER: 0001275287-05-002266 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20050621 ITEM INFORMATION: Other Events ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20050621 DATE AS OF CHANGE: 20050621 FILER: COMPANY DATA: COMPANY CONFORMED NAME: SANGAMO BIOSCIENCES INC CENTRAL INDEX KEY: 0001001233 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 680359556 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 000-30171 FILM NUMBER: 05906983 BUSINESS ADDRESS: STREET 1: 501 CANAL BLVD STREET 2: SUITE A100 CITY: RICHMOND STATE: CA ZIP: 94804 BUSINESS PHONE: 5109706000 MAIL ADDRESS: STREET 1: 501 CANAL BLVD STREET 2: SUITE A100 CITY: RICHMOND STATE: CA ZIP: 94804 8-K 1 sb2948.txt ================================================================================ UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 21, 2005 SANGAMO BIOSCIENCES, INC. ------------------------------------------------------ (Exact Name of Registrant as Specified in Its Charter) Delaware ---------------------------------------------- (State or Other Jurisdiction of Incorporation) 000-30171 68-0359556 ------------------------ --------------------------------- (Commission File Number) (IRS Employer Identification No.) 501 Canal Blvd, Suite A100 Richmond, California 94804 - ----------------------------------------------- ---------- (Address of Principal Executive Offices) (Zip Code) (510) 970-6000 ---------------------------------------------------- (Registrant's Telephone Number, Including Area Code) ------------------------------------------------------------- (Former Name or Former Address, if Changed Since Last Report) Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): [ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) [ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) [ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) [ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) ================================================================================ ITEM 8.01 OTHER EVENTS On June 21, 2005, Sangamo BioSciences Inc. issued a press release announcing that data from several of their programs to develop ZFP Therapeutics will be presented at the third Annual Meeting of the International Society for Stem Cell Research. A copy of the press release issued by Sangamo BioSciences, Inc. relating to this event is filed as an exhibit to this Current Report on Form 8-K. ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS (c) Exhibits. The following material is filed as an exhibit to this Current Report on Form 8-K: Exhibit No. - ----------- 99.1 Press Release Issued June 21, 2005. SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. DATE: June 21, 2005 SANGAMO BIOSCIENCES, INC. By: /s/ EDWARD O. LANPHIER II ---------------------------------- Edward O. Lanphier II President, Chief Executive Officer EX-99.1 2 sb2948ex991.txt Exhibit 99.1 SANGAMO BIOSCIENCES ZFP THERAPEUTIC(TM) DATA TO BE PRESENTED AT THE 3RD ANNUAL MEETING OF THE INTERNATIONAL SOCIETY FOR STEM CELL RESEARCH PRESENTATIONS COVER ZFP-MEDIATED GENE REGULATION AND GENE MODIFICATION PROGRAMS RICHMOND, Calif., June 21 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) today announced the Company will present data from its programs to develop novel zinc finger DNA-binding protein (ZFP) Therapeutics(TM) at the third Annual Meeting of the International Society for Stem Cell Research (ISSCR). The meeting will take place in San Francisco from June 23rd through June 25th. "Our scientists and collaborators will present data from a variety of our programs that demonstrate the use of Sangamo's proprietary ZFP technology to facilitate the development of novel therapeutics employing stem cells," stated Edward Lanphier, President and CEO of Sangamo BioSciences, Inc. "We are excited to have four presentations at the ISSCR meeting. It is an ideal forum for us to discuss our zinc finger nuclease (ZFN)-mediated gene correction and gene disruption data as many of the therapeutic applications of this technology will be in hematopoietic stem cells and this meeting attracts the leaders of this exciting and developing field." Sangamo scientists and their collaborators will make the following presentations; the abstract numbers, titles and presenters are listed below: #441: Genome Editing in Human Stem Cells Using Engineered Zinc Finger Nucleases. Angelo Lombardo, HSR-TIGET, San Raffaele Scientific Institute, Milan, Italy Saturday, June 25, 2005. Technology Development Plenary Session podium presentation. #660: Highly Efficient Endogenous Human Gene Correction Using Designed Zinc Finger Nucleases. Michael C. Holmes, Sangamo BioSciences, Inc. Thursday, June 23, 2005. Poster presentation. #698: Towards Gene Correction Therapy For Wiskott-Aldrich Syndrome With Engineered Zinc Finger Nucleases. Michael C. Holmes, Sangamo BioSciences, Inc. Friday, June 24, 2005. Podium presentation. #841: Towards Gene Knock Out Therapy For AIDS/HIV: Targeted Disruption of CCR5 Using Engineered Zinc Finger Protein Nucleases. Y. Jouvenot, Sangamo BioSciences, Inc. Saturday, June 25, 2005. Podium presentation. Additional information about the 3rd Annual Meeting of the ISSCR is available at: www.isscr.org. Zinc Finger DNA Binding Proteins Zinc Finger DNA-binding Proteins (ZFPs) are a naturally occurring class of DNA binding proteins. The DNA recognition and binding function of ZFPs can be engineered and thus directed to a targeted sequence of DNA. This permits the delivery of a variety of functional domains to a gene-specific location. ZFPs are being developed for two significant therapeutic applications: gene regulation and gene modification. In the case of therapeutic gene regulation, ZFPs are being engineered to either turn on therapeutically beneficial genes or turn off the expression of disease-causing genes. For gene modification, ZFPs are being used in combination with a DNA cutting enzyme (endonuclease) functional domain to generate ZFNs that facilitate the correction of mutant gene sequences that cause disease or the disruption of genes that facilitate disease progression. About Sangamo Sangamo BioSciences, Inc. is focused on the research and development of novel DNA-binding proteins for therapeutic gene regulation and modification. The most advanced ZFP Therapeutic(TM) development programs are currently in Phase I clinical trials for evaluation of safety in patients with peripheral artery disease and diabetic neuropathy. Other therapeutic development programs are focused on ischemic heart disease, congestive heart failure, cancer, neuropathic pain, and infectious and monogenic diseases. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also developing sequence-specific ZFP Nucleases (ZFN(TM)) for therapeutic gene modification as a treatment and possible cure for a variety of monogenic diseases, such as sickle cell anemia, and for infectious diseases such as HIV. For more information about Sangamo, visit the company's web site at http://www.sangamo.com/ or http://www.expressinglife.com/ . This press release may contain forward-looking statements based on Sangamo's current expectations. These forward-looking statements include, without limitation, references to the research and development of novel ZFP TFs and ZFNs, clinical trials and therapeutic applications of Sangamo's ZFP technology platform. Actual results may differ materially from these forward- looking statements due to a number of factors, including technological challenges, Sangamo's ability to develop commercially viable products and technological developments by our competitors. See the company's SEC filings, and in particular, the risk factors described in the company's Annual Report on Form 10-K and its most recent 10-Q. Sangamo assumes no obligation to update the forward-looking information contained in this press release. SOURCE Sangamo BioSciences, Inc. -0- 06/21/2005 /CONTACT: Elizabeth Wolffe, Ph.D. of Sangamo BioSciences, Inc., +1-510-970-6000, ext. 271, or ewolffe@sangamo.com; or media, Justin Jackson, +1-212-213-0006, or jjackson@burnsmc.com, or investors, John Cummings, +1-415-352-6262, both of Burns McClellan, Inc., for Sangamo BioSciences, Inc./ /Web site: http://www.sangamo.com / -----END PRIVACY-ENHANCED MESSAGE-----