-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TUkOYam3ryzRniAXGD1tT+zr7j0OsE85fNo3gc0s5GgBbJzjenUU4Pb36ZSRLuJQ
 6PRki6Q8LEHvkOFG0DZLzA==

<SEC-DOCUMENT>0001209191-06-035537.txt : 20060608
<SEC-HEADER>0001209191-06-035537.hdr.sgml : 20060608
<ACCEPTANCE-DATETIME>20060608143623
ACCESSION NUMBER:		0001209191-06-035537
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060607
FILED AS OF DATE:		20060608
DATE AS OF CHANGE:		20060608

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Wolff Henry Ward
		CENTRAL INDEX KEY:			0001302390

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30171
		FILM NUMBER:		06893769

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		510-608-6500

	MAIL ADDRESS:	
		STREET 1:		6701 KAISER DRIVE
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SANGAMO BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001001233
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				680359556
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		501 CANAL BLVD
		STREET 2:		SUITE A100
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94804
		BUSINESS PHONE:		5109706000

	MAIL ADDRESS:	
		STREET 1:		501 CANAL BLVD
		STREET 2:		SUITE A100
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94804
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>bsf20961_bsf8hww.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2006-06-07</periodOfReport>

    <issuer>
        <issuerCik>0001001233</issuerCik>
        <issuerName>SANGAMO BIOSCIENCES INC</issuerName>
        <issuerTradingSymbol>SGMO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001302390</rptOwnerCik>
            <rptOwnerName>Wolff Henry Ward</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SANGAMO BIOSCIENCES INC, STE A-100</rptOwnerStreet1>
            <rptOwnerStreet2>POINT RICHMOND TECH CNTR, 501 CANAL BL.</rptOwnerStreet2>
            <rptOwnerCity>RICHMOND</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94804</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>7.73</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2006-06-07</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>50000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2016-06-07</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>50000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>50000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Option is immediately exercisable for all option shares.  Shares purchased pursuant to the option are subject to repurchase by the issuer at the lower of (i) the original exercise price and (ii) the fair market value of the issuer's common stock at the time of repurchase if the Reporting Person's Board service ceases prior to full vesting.  This repurchase right lapses, and the option shares vest, in 36 equal monthly installments upon the Reporting Person's completion of each month of Board service over the 36-month period measured from the option grant date.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ H. Ward Wolff</signatureName>
        <signatureDate>2006-06-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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