SANGAMO BIOSCIENCES, INC.

501 CANAL BOULEVARD

RICHMOND, CALIFORNIA 94804

April 25, 2016

VIA EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, NE

Washington, DC 20549

Mail Stop 4720

Attention:	Michael Gershon
	Erin K. Jaskot

Re: Sangamo BioSciences, Inc.

Post-Effective Amendment No. 2 to Registration Statement on Form S-3ASR

Filed February 18, 2016

File No. 333-194126

Dear Mr. Gershon:

In accordance with Rule 461 under the Securities Act of 1933, as amended, Sangamo BioSciences, Inc. (the “Company”) hereby requests the acceleration of the effective date of the above referenced Post-Effective Amendment No. 2 to Registration Statement on Form S-3ASR of the Company so that it will become effective on April 27, 2016 at 5:00 p.m. Eastern Time, or as soon thereafter as practicable.

In connection therewith, the Company acknowledges that:

• Should the Securities and Exchange Commission (the “Commission”) or the staff, acting pursuant to delegated authority, declare the filing effective, it does not foreclose the Commission from taking any action with respect to the filing;

• The action of the Commission or the staff, acting pursuant to delegated authority, in declaring the filing effective, does not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the filing; and

• The Company may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

Very truly yours,

SANGAMO BIOSCIENCES, INC.
By:	/s/ Edward O. Lanphier II
	Name: Edward O. Lanphier II
	Title:   Chief Executive Officer

cc:   Suzanne Hayes, Assistant Director, Division of Corporation Finance