-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 IH6vnO3j64/dpnNczGn7AiTXWgLH+roE0GhcnSXqWVi51H/jdjv9fYfau2oorZlm
 BDU5TyFntAOxN03MfxRgxg==

<SEC-DOCUMENT>0001104659-03-021743.txt : 20030929
<SEC-HEADER>0001104659-03-021743.hdr.sgml : 20030929
<ACCEPTANCE-DATETIME>20030929180135
ACCESSION NUMBER:		0001104659-03-021743
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030917
FILED AS OF DATE:		20030929

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ZANTE GREG
		CENTRAL INDEX KEY:			0001264949

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30171
		FILM NUMBER:		03915975

	MAIL ADDRESS:	
		STREET 1:		C/O SANGAMO BIOSCIENCES, INC STE-A-100
		STREET 2:		POINT RICHMOND TECH, 501 CANAL BLVD,
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94804

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SANGAMO BIOSCIENCES INC
		CENTRAL INDEX KEY:			0001001233
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				680359556
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		501 CANAL BLVD
		STREET 2:		SUITE A100
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94804
		BUSINESS PHONE:		5109706000

	MAIL ADDRESS:	
		STREET 1:		501 CANAL BLVD
		STREET 2:		SUITE A100
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94804
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>a3.xml
<DESCRIPTION>3
<TEXT>
<XML>
<?xml version="1.0" encoding="utf-8"?>
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>3</documentType>
  <periodOfReport>2003-09-17</periodOfReport>
    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001001233</issuerCik>
        <issuerName>SANGAMO BIOSCIENCES INC</issuerName>
        <issuerTradingSymbol>SGMO</issuerTradingSymbol>
  </issuer>
  <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001264949</rptOwnerCik>
            <rptOwnerName>ZANTE GREG</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SANGAMO BIOSCIENCES, INC STE-A-100</rptOwnerStreet1>
            <rptOwnerStreet2>POINT RICHMOND TECH, 501 CANAL BLVD,</rptOwnerStreet2>
            <rptOwnerCity>RICHMOND</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94804</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
      <isDirector>0</isDirector>
      <isOfficer>1</isOfficer>
      <isTenPercentOwner>0</isTenPercentOwner>
      <isOther>0</isOther>
      <officerTitle>Sr Dir., Finance and Admin.</officerTitle>
    </reportingOwnerRelationship>
  </reportingOwner>
  <derivativeTable>
    <derivativeHolding>
      <securityTitle>
        <value>Stock Options (Right to Buy)</value>
      </securityTitle>
      <conversionOrExercisePrice>
        <value>3.00</value>
      </conversionOrExercisePrice>
      <exerciseDate>
        <footnoteId id="F1"/>
      </exerciseDate>
      <expirationDate>
        <value>2013-08-17</value>
      </expirationDate>
      <underlyingSecurity>
        <underlyingSecurityTitle>
          <value>Common Stock</value>
        </underlyingSecurityTitle>
        <underlyingSecurityShares>
          <value>20000</value>
        </underlyingSecurityShares>
      </underlyingSecurity>
      <ownershipNature>
        <directOrIndirectOwnership>
          <value>D</value>
        </directOrIndirectOwnership>
      </ownershipNature>
    </derivativeHolding>
  </derivativeTable>
  <footnotes>
    <footnote id="F1">Option is immediately exercisable, subject to repurchase of the option shares by the Issuer at the exercise price prior to full vesting.  the repurchase right lapses, and the options vest, as follows:  (i) 25% of the option shares on August 18, 2004, and (ii) the remaining shares vest in a series of successive monthly installments over the remaining 36 months thereafter. </footnote>
  </footnotes>
  <ownerSignature>
    <signatureName>/s/ Greg Zante</signatureName>
    <signatureDate>2003-09-29</signatureDate>
  </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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