Stock-Based Compensation - Exercise Price for Stock Options Outstanding and Exercisable (Details) - $ / shares	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Exercise prices for stock options outstanding and exercisable
Number of stock options outstanding (in shares)	13,953,818
Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 32.89
Stock options
Exercise prices for stock options outstanding and exercisable
Exercise prices, outstanding stock option awards, low end of range (in dollars per share)	10.01
Exercise prices, outstanding stock option awards, high end of range (in dollars per share)	$ 70.00
Number of stock options outstanding (in shares)	26,702,903	27,248,662	13,715,612	14,202,039
Options Outstanding, Weighted-Average Remaining Contractual Life	7 years 8 months 8 days
Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 34.95	$ 34.85	$ 41.71	$ 42.08
Number of stock options exercisable	7,741,300	5,193,238	2,507,834
Options Exercisable, Weighted-Average Remaining Contractual Life	6 years 11 months 19 days
Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 37.04	$ 40.21	$ 44.93
Stock options | Range Of Exercise Prices $10.01 - $20.00
Exercise prices for stock options outstanding and exercisable
Exercise prices, outstanding stock option awards, low end of range (in dollars per share)	10.01
Exercise prices, outstanding stock option awards, high end of range (in dollars per share)	$ 20.00
Number of stock options outstanding (in shares)	206,500
Options Outstanding, Weighted-Average Remaining Contractual Life	7 years 2 months 19 days
Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 18.70
Number of stock options exercisable	39,370
Options Exercisable, Weighted-Average Remaining Contractual Life	7 years 8 months 19 days
Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 18.70
Stock options | Range of Exercise Prices $20.01 - $30.00
Exercise prices for stock options outstanding and exercisable
Exercise prices, outstanding stock option awards, low end of range (in dollars per share)	20.01
Exercise prices, outstanding stock option awards, high end of range (in dollars per share)	$ 30.00
Number of stock options outstanding (in shares)	12,963,749
Options Outstanding, Weighted-Average Remaining Contractual Life	9 years 14 days
Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 27.69
Number of stock options exercisable	2,667,053
Options Exercisable, Weighted-Average Remaining Contractual Life	8 years 11 months 12 days
Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 27.61
Stock options | Range of Exercise Prices $30.01 - $40.00
Exercise prices for stock options outstanding and exercisable
Exercise prices, outstanding stock option awards, low end of range (in dollars per share)	30.01
Exercise prices, outstanding stock option awards, high end of range (in dollars per share)	$ 40.00
Number of stock options outstanding (in shares)	8,293,326
Options Outstanding, Weighted-Average Remaining Contractual Life	6 years 8 months 15 days
Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 35.39
Number of stock options exercisable	3,239,177
Options Exercisable, Weighted-Average Remaining Contractual Life	6 years 7 months 2 days
Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 35.50
Stock options | Range of Exercise Prices $40.01 - $50.00
Exercise prices for stock options outstanding and exercisable
Exercise prices, outstanding stock option awards, low end of range (in dollars per share)	40.01
Exercise prices, outstanding stock option awards, high end of range (in dollars per share)	$ 50.00
Number of stock options outstanding (in shares)	2,516,602
Options Outstanding, Weighted-Average Remaining Contractual Life	7 years 5 months 8 days
Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 45.31
Number of stock options exercisable	860,700
Options Exercisable, Weighted-Average Remaining Contractual Life	5 years 4 months 24 days
Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 47.35
Stock options | Range of Exercise Prices $50.01 - $60.00
Exercise prices for stock options outstanding and exercisable
Exercise prices, outstanding stock option awards, low end of range (in dollars per share)	50.01
Exercise prices, outstanding stock option awards, high end of range (in dollars per share)	$ 60.00
Number of stock options outstanding (in shares)	1,798,126
Options Outstanding, Weighted-Average Remaining Contractual Life	4 years 6 months 10 days
Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 57.60
Number of stock options exercisable	515,100
Options Exercisable, Weighted-Average Remaining Contractual Life	3 years 10 months 24 days
Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 57.06
Stock options | Range of Exercise Prices $60.01 - $70.00
Exercise prices for stock options outstanding and exercisable
Exercise prices, outstanding stock option awards, low end of range (in dollars per share)	60.01
Exercise prices, outstanding stock option awards, high end of range (in dollars per share)	$ 70.00
Number of stock options outstanding (in shares)	924,600
Options Outstanding, Weighted-Average Remaining Contractual Life	4 years 4 months 28 days
Options Outstanding, Weighted-Average Exercise Price (in dollars per share)	$ 64.26
Number of stock options exercisable	419,900
Options Exercisable, Weighted-Average Remaining Contractual Life	4 years 3 months 10 days
Options Exercisable, Weighted-Average Exercise Price (in dollars per share)	$ 64.91