CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenue:
Revenue	$ 3,357	$ 10,773	$ 7,339	$ 20,426
Expenses:
Research and development	30,417	44,542	65,890	89,056
General and administrative	9,606	8,224	18,338	16,876
Total expenses	40,023	52,766	84,228	105,932
Loss from operations	(36,666)	(41,993)	(76,889)	(85,506)
Other income (expense):
Investment income	474	807	894	1,338
Interest expense	(3,403)	(3,403)	(6,806)	(6,806)
Other income (expense)	(8)	97	(20)	130
Net loss	$ (39,603)	$ (44,492)	$ (82,821)	$ (90,844)
Basic and diluted net loss per share	$ (1.69)	$ (2.37)	$ (3.77)	$ (5.10)
Basic and diluted weighted average number of common shares outstanding	23,473	18,796	21,966	17,828
Grant and other [Member]
Revenue:
Revenue	$ 3,357	$ 10,773	$ 7,339	$ 20,426