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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Revenue:    
Revenue $ 3,982 $ 9,653
Expenses:    
Research and development 35,473 44,514
General and administrative 8,732 8,652
Total expenses 44,205 53,166
Loss from operations (40,223) (43,513)
Other income (expense):    
Investment income 420 531
Interest expense (3,403) (3,403)
Other income (expense) (12) 33
Net loss $ (43,218) $ (46,352)
Basic and diluted net loss per share $ (0.11) $ (0.14)
Basic and diluted weighted average number of common shares outstanding 408,843 336,972
Grant and other [Member]    
Revenue:    
Revenue $ 3,982 $ 9,653