CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenue:
Grant and other	$ 9,653	$ 5,680
Total revenue	9,653	5,680
Expenses:
Research and development	44,514	37,654
General and administrative	8,652	8,852
Total expenses	53,166	46,506
Loss from operations	(43,513)	(40,826)
Other income (expense):
Investment income	531	474
Interest expense	(3,403)	(3,513)
Other income (expense)	33	11
Net loss	$ (46,352)	$ (43,854)
Basic and diluted net loss per share	$ (0.14)	$ (0.16)
Basic and diluted weighted average number of common shares outstanding	336,972	274,178