Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Income Tax Disclosure [Abstract]

Company’s loss from operations before income tax expense by jurisdiction

The Company’s loss from operations before income tax expense by jurisdiction for the year ended December 31 are as follows (in thousands):

	2016		2015		2014
Domestic	$	(273,134)	$	(150,227)	$	(76,742)
Foreign		(6,832)		(6,710)		(6,205)
Total net loss	$	(279,966)	$	(156,937)	$	(82,947)

Deferred Tax Assets (Liabilities)

Deferred tax assets (liabilities) consist of the following at December 31 (in thousands):

	2016		2015
Net operating losses U.S.	$	286,619	$	203,284
Net operating losses foreign		9,011		8,360
Research tax credits		23,260		16,491
Deferred revenue		10,121		922
Original discount interest		12,445		—
Other		17,981		11,981
Total deferred tax assets		359,437		241,038
Intangibles		(2,090)		(2,415)
Other		(2,817)		(1,767)
Total deferred tax liabilities		(4,907)		(4,182)
Net deferred tax assets		354,530		236,856
Less valuation allowance		(354,530)		(236,856)
Deferred tax assets, net	$	—	$	—

Tax Rate Differences

The differences between the U.S. federal statutory tax rate and the Company’s effective tax rate are as follows:

	2016			2015			2014
Statutory federal tax rate		(34)	%		(34)	%		(34)	%
State income taxes, net of federal benefit		(3)	%		(3)	%		(3)	%
Research and development and other tax credits		(2)	%		(3)	%		(2)	%
Release of FIN 48 liability		0	%		(2)	%		0	%
Other		2	%		1	%		2	%
Change in valuation allowance		37	%		41	%		37	%
		0	%		0	%		0	%

Tax Return Reported Federal Net Operating Losses and Tax Credits Available

As of December 31, 2016, the Company had tax return reported federal net operating losses and tax credits available as follows (in thousands):

	Amount
Federal net operating losses expiring through the year 2036	$	781,019
Foreign net operating losses (no expiration)		40,957
Research tax credits expiring through the year 2036		23,166
Alternative-minimum tax credit (no expiration)		94

Reconciliation of Unrecognized Tax Benefits

Tabular Reconciliation of Unrecognized Tax Benefits (in thousands):

	Amount
Unrecognized tax benefits as of January 1, 2015	$	4,801
Gross increases — tax positions in prior period		—
Gross decreases — tax positions in prior period		4,587
Gross increases — current-period tax positions		—
Increases (decreases) from settlements		—
Unrecognized tax benefits as of December 31, 2015	$	214
Gross increases — tax positions in prior period		—
Gross decreases — tax positions in prior period		214
Gross increases — current-period tax positions		—
Increases (decreases) from settlements		—
Unrecognized tax benefits as of December 31, 2016	$	—