Income Taxes (Tables)

12 Months Ended

Dec. 31, 2014

Income Tax Disclosure [Abstract]

Summary of Operating Loss Carryforwards [Table Text Block]

The Company losses by jurisdiction are as follows (in thousands):

	2014		2013		2012
Domestic	$	(76,742)	$	(48,691)	$	(28,507)
Foreign		(6,205)		(3,292)		—
Total net loss	$	(82,947)	$	(51,983)	$	(28,507)

Components of The Income Tax Provision (Benefit)

The components of the income tax provision are as follows (in thousands):

	2014		2013		2012
Current U.S.	$	—	$	—	$	—
Current foreign		—		25		—
Deferred		—		—		—
Net provision	$	—	$	25	$	—

Deferred Tax Assets (Liabilities)

Deferred tax assets (liabilities) consist of the following at December 31 (in thousands):

	2014		2013
Net operating losses U.S.	$	148,451	$	123,907
Net operating losses foreign		6,535		6,405
Research tax credits		11,068		9,175
Other		9,963		6,844
Total deferred tax assets		176,017		146,331
Intangibles		(2,773)		(3,573)
Other		(321)		(227)
Total deferred tax liabilities		(3,094)		(3,800)
Net deferred tax assets		172,923		142,531
Less valuation allowance		(172,923)		(142,531)
Deferred tax assets, net	$	—	$	—

Tax Rate Differences

The differences between the U.S. federal statutory tax rate and the Company’s effective tax rate are as follows:

	2014		2013		2012
Statutory federal tax rate	(34)	%	(34)	%	(34)	%
State income taxes, net of federal benefit	(3)	%	(3)	%	(8)	%
Research and development and other tax credits	(2)	%	(7)	%	0	%
Expiration of net operating losses	0	%	0	%	6	%
Other	2	%	3	%	3	%
Change in valuation allowance	37	%	41	%	33	%
	0	%	0	%	0	%

Tax Return Reported Federal Net Operating Losses and Tax Credits Available

As of December 31, 2014, the Company had tax return reported federal net operating losses and tax credits available as follows (in thousands):

	Amount
Federal net operating losses expiring through the year 2034	$	402,192
Foreign net operating losses (no expiration)		29,705
Research tax credits expiring through the year 2034		10,975
Alternative-minimum tax credit (no expiration)		94

Reconciliation of Unrecognized Tax Benefits

Tabular Reconciliation of Unrecognized Tax Benefits (in thousands):

	Amount
Unrecognized tax benefits as of January 1, 2013	$	4,801
Gross increases — tax positions in prior period		—
Gross decreases — tax positions in prior period		—
Gross increases — current-period tax positions		—
Increases (decreases) from settlements		—
Unrecognized tax benefits as of December 31, 2013	$	4,801
Gross increases — tax positions in prior period		—
Gross decreases — tax positions in prior period		—
Gross increases — current-period tax positions		—
Increases (decreases) from settlements		—
Unrecognized tax benefits as of December 31, 2014	$	4,801