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STATEMENTS OF CASH FLOWS (USD $)
In Thousands, unless otherwise specified
6 Months Ended
Jun. 30, 2012
Jun. 30, 2011
Operating Activities:    
Net loss $ (13,256) $ (12,446)
Reconciliation of net loss to net cash used in operating activities:    
Change in fair value of warrant liability 0 (1,237)
Depreciation and amortization 810 788
Amortization of net premiums on short-term investments   231
Gain on disposal of property and equipment (19)  
Deferred rent 251 (168)
Non-cash stock-based compensation 1,176 1,135
Changes in operating assets and liabilities:    
Accounts receivables 467 (1,778)
Unbilled receivables (2,395) (2,020)
Prepaid expenses and other assets 58 (636)
Accounts payable and accrued expenses 1,562 (3,808)
Deferred revenue   2,500
Lease incentives received 1,000  
Net cash used in operating activities (10,346) (17,439)
Investing Activities:    
Capital expenditures (1,076) (178)
Proceeds from disposal of property and equipment 167  
Proceeds from maturities of short-term investments 2,500 15,375
Purchases of short-term investments (9,389) (1,082)
Net cash (used in) provided by investing activities (7,798) 14,115
Financing Activities:    
Principal payments of notes payable (20) (40)
Proceeds from notes payable 100  
Restricted cash (755)  
Net proceeds from sales of common stock, net of offering costs of $0.3 million and $0.2 million, respectively 20,023 8,280
Proceeds from the exercise of stock options 26 115
Net cash provided by financing activities 19,374 8,355
Net increase in cash and cash equivalents 1,230 5,031
Cash and cash equivalents at beginning of period 14,104 8,061
Cash and cash equivalents at end of period 15,334 13,092
Supplemental disclosure of non-cash activities:    
Deposit applied towards the purchase of laboratory equipment 500  
Equipment purchases included in accounts payable and accrued expenses $ 278 $ 34