CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenue:
Revenue	$ 2,507	$ 7,735	$ 9,846	$ 28,161
Expenses:
Research and development	18,611	41,326	84,502	130,382
Gain on Catalent transaction	(9,016)	0	(9,016)	0
General and administrative	7,899	8,309	26,236	25,185
Total expenses	17,494	49,635	101,722	155,567
Loss from operations	(14,987)	(41,900)	(91,876)	(127,406)
Other income (expense):
Investment income	342	752	1,236	2,090
Interest expense	(3,403)	(3,403)	(10,209)	(10,209)
Other income (expense)	5	(19)	(15)	111
Net loss	$ (18,043)	$ (44,570)	$ (100,864)	$ (135,414)
Basic and diluted net loss per share	$ (0.74)	$ (2.33)	$ (4.43)	$ (7.42)
Basic and diluted weighted average number of common shares outstanding	24,327	19,116	22,761	18,262
Grant and other [Member]
Revenue:
Revenue	$ 2,507	$ 7,735	$ 9,846	$ 28,161