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Other Financial Information
 12 Months Ended
Dec. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Other Financial Information Other Financial Information
Prepaid Expenses and Other Current Assets
Prepaid expenses and other current assets consist of the following as of (in thousands):
December 31,
20232022
Prepaid expenses$70,297 $160,773 
Other current assets155,726 76,374 
Prepaid expenses and other current assets$226,023 $237,147 
Property and Equipment, net
Property and equipment is comprised of the following as of (in thousands):
December 31,
20232022
Land and buildings$102,916 $101,342 
Machinery and equipment148,243 134,809 
Leasehold improvements48,310 18,895 
Computer hardware5,114 4,927 
Construction in progress76,156 81,566 
380,739 341,539 
Less: accumulated depreciation(74,968)(47,292)
Property and equipment, net$305,771 $294,247 
As of December 31, 2023 and 2022, approximately $155 million and $170 million, respectively, of net assets used in operations were located in the Czech Republic. Depreciation expense was approximately $41 million, $29 million, and $13 million for the years ended December 31, 2023, 2022, and 2021, respectively.
Accrued Expenses
Accrued expenses consist of the following as of (in thousands):
December 31,
20232022
Employee benefits and compensation$55,952 $52,569 
Gross-to-net deductions
20,616 — 
U.S. product sales returns accrual
82,506 — 
Research and development accruals131,027 468,214 
Other accrued expenses104,567 70,375 
Accrued expenses$394,668 $591,158 
Other Current Liabilities
Other current liabilities consist of the following as of (in thousands):
December 31,
20232022
Refunds due to APA customers
$142,165 $210,362 
Other current liability related to Gavi (see Note 3)
696,390 697,384 
Other current liabilities22,853 22,309 
Total other current liabilities$861,408 $930,055