Collaboration, License, and Supply Agreements (Details) $ / shares in Units, $ in Thousands, shares in Millions, dose in Millions	1 Months Ended	3 Months Ended		9 Months Ended
	Aug. 31, 2023 USD ($) $ / shares shares	Sep. 30, 2023 USD ($) installment $ / shares	Sep. 30, 2022 USD ($)	Sep. 30, 2023 USD ($) installment $ / shares	Sep. 30, 2022 USD ($)	Dec. 31, 2022 USD ($) installment $ / shares	Dec. 31, 2021 USD ($)	Sep. 30, 2021 dose
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Royalty period				15 years
Deferred revenue		$ 801,029	$ 1,440,194	$ 801,029	$ 1,440,194	$ 549,551	$ 1,595,472
Common stock, par value per share (in usd per share) | $ / shares		$ 0.01		$ 0.01		$ 0.01
Net proceeds from sales of common stock				$ 256,995	179,385
Research and development		$ 106,229	304,297	572,805	977,428
Takeda Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of doses to be distributed | dose								150
Settlement Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement payment	$ 149,800	$ 185,000	185,000	$ 185,000	185,000
Initial reservation fee	130,400		$ 47,800		$ 47,800
Deferred revenue	4,000
Number of quarterly installment payments | installment		2		2		4
Settlement agreement, quarterly installment amount		$ 34,300		$ 34,300
Settlement Agreement | Accrued Liabilities
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement payment		68,600		68,600
Securities Subscription Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement agreement, benefit		79,200		79,200
Research and development		$ 57,700		$ 57,700
Loss on firm purchase commitments	$ 21,500
Securities Subscription Arrangement | Private Placement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Shares sell and issue | shares	6.5
Common stock, par value per share (in usd per share) | $ / shares	$ 0.01
Share, price per share (in usd per share) | $ / shares	$ 13.00
Net proceeds from sales of common stock	$ 84,500
Common stock, quoted market price	46,500
Common stock, premium paid	$ 38,000