CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Revenue:
Revenues	$ 186,986	$ 734,577	$ 692,363	$ 1,624,473
Expenses:
Cost of sales	98,929	434,593	188,792	720,874
Research and development	106,229	304,297	572,805	977,428
Selling, general, and administrative	107,460	122,876	313,709	327,028
Total expenses	312,618	861,766	1,075,306	2,025,330
Loss from operations	(125,632)	(127,189)	(382,943)	(400,857)
Other income (expense):
Interest expense	(2,859)	(4,169)	(10,299)	(15,279)
Other income (expense)	(2,982)	(34,783)	26,912	(53,002)
Loss before income taxes	(131,473)	(166,141)	(366,330)	(469,138)
Income tax expense (benefit)	(697)	2,472	343	6,552
Net loss	$ (130,776)	$ (168,613)	$ (366,673)	$ (475,690)
Net loss per share:
Basic (in usd per share)	$ (1.26)	$ (2.15)	$ (3.94)	$ (6.13)
Diluted (in usd per share)	$ (1.26)	$ (2.15)	$ (3.94)	$ (6.13)
​Weighted average number of common shares outstanding
Basic (in shares)	103,429	78,274	93,046	77,631
Diluted (in shares)	103,429	78,274	93,046	77,631
Product sales
Revenue:
Revenues	$ 2,231	$ 626,091	$ 279,937	$ 1,267,174
Grants
Revenue:
Revenues	164,922	106,273	389,380	313,348
Royalties and other
Revenue:
Revenues	$ 19,833	$ 2,213	$ 23,046	$ 43,951