Collaboration, License, and Supply Agreements (Details) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023 USD ($) installment	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($) installment	Jun. 30, 2022 USD ($)	Sep. 30, 2022 USD ($) installment	Sep. 30, 2021 dose
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Royalty period			15 years
Research and development	$ 219,475	$ 289,648	$ 466,576	$ 673,131
Takeda Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of doses to be distributed | dose						150,000,000
Settlement Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement payment					$ 185,000
Initial reservation fee					$ 47,800
Number of quarterly installment payments | installment	2		2		4
Settlement agreement, quarterly installment amount					$ 34,300
Research and development			$ 20,400
Settlement Agreement | Accrued Liabilities
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement payment	$ 68,600		$ 68,600