CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenue:
Revenues	$ 424,426	$ 185,925	$ 505,377	$ 889,896
Expenses:
Cost of sales	55,777	271,077	89,863	286,281
Research and development	219,475	289,648	466,576	673,131
Selling, general, and administrative	93,717	108,160	206,249	204,152
Total expenses	368,969	668,885	762,688	1,163,564
Income (Loss) from operations	55,457	(482,960)	(257,311)	(273,668)
Other income (expense):
Interest expense	(3,124)	(6,234)	(7,440)	(11,110)
Other income (expense)	5,532	(19,873)	29,894	(18,219)
Income (Loss) before income tax expense (benefit)	57,865	(509,067)	(234,857)	(302,997)
Income tax expense (benefit)	(143)	1,418	1,040	4,080
Net income (loss)	$ 58,008	$ (510,485)	$ (235,897)	$ (307,077)
Earnings Per Share [Abstract]
Basic (in usd per share)	$ 0.65	$ (6.53)	$ (2.69)	$ (3.97)
Diluted (in usd per share)	$ 0.58	$ (6.53)	$ (2.69)	$ (3.97)
​Weighted average number of common shares outstanding
Basic (in shares)	89,362	78,143	87,769	77,305
Diluted (in shares)	104,065	78,143	87,769	77,305
Product sales
Revenue:
Revenues	$ 285,163	$ 55,455	$ 277,706	$ 641,083
Grants
Revenue:
Revenues	137,079	107,774	224,458	207,075
Royalties and other
Revenue:
Revenues	$ 2,184	$ 22,696	$ 3,213	$ 41,738