Stock-Based Compensation - Stock Options and Appreciation Rights (Details)	3 Months Ended
	Mar. 31, 2023 $ / shares shares
2023 Inducement Plan
Stock Options
Outstanding, beginning balance (in shares) | shares	0
Granted (in shares) | shares	358,600
Exercised (in shares) | shares	0
Canceled (in shares) | shares	0
Outstanding, ending balance (in shares) | shares	358,600
Shares exercisable (in shares) | shares	0
Weighted-Average Exercise Price
Outstanding, beginning balance (in usd per share) | $ / shares	$ 0
Granted (in usd per share) | $ / shares	10.96
Exercised (in usd per share) | $ / shares	0
Canceled (in usd per share) | $ / shares	0
Outstanding, ending balance (in usd per share) | $ / shares	10.96
Shares exercisable (in usd per share) | $ / shares	$ 0
2015 Plan
Stock Options
Outstanding, beginning balance (in shares) | shares	4,053,290
Granted (in shares) | shares	927,742
Exercised (in shares) | shares	(5,031)
Canceled (in shares) | shares	(15,835)
Outstanding, ending balance (in shares) | shares	4,960,166
Shares exercisable (in shares) | shares	311,560
Weighted-Average Exercise Price
Outstanding, beginning balance (in usd per share) | $ / shares	$ 46.07
Granted (in usd per share) | $ / shares	7.20
Exercised (in usd per share) | $ / shares	6.81
Canceled (in usd per share) | $ / shares	81.44
Outstanding, ending balance (in usd per share) | $ / shares	38.73
Shares exercisable (in usd per share) | $ / shares	$ 40.60
2005 Plan
Stock Options
Outstanding, beginning balance (in shares) | shares	63,725
Granted (in shares) | shares	0
Exercised (in shares) | shares	0
Canceled (in shares) | shares	(5,250)
Outstanding, ending balance (in shares) | shares	58,475
Shares exercisable (in shares) | shares	58,475
Weighted-Average Exercise Price
Outstanding, beginning balance (in usd per share) | $ / shares	$ 112.94
Granted (in usd per share) | $ / shares	0
Exercised (in usd per share) | $ / shares	0
Canceled (in usd per share) | $ / shares	36.60
Outstanding, ending balance (in usd per share) | $ / shares	119.80
Shares exercisable (in usd per share) | $ / shares	$ 119.80