CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Revenue:
Revenues	$ 80,951	$ 703,971
Expenses:
Cost of sales	34,086	15,204
Research and development	247,101	383,483
Selling, general, and administrative	112,532	95,992
Total expenses	393,719	494,679
Income (Loss) from operations	(312,768)	209,292
Other income (expense):
Interest expense	(4,316)	(4,876)
Other income	24,362	1,654
Income (Loss) before income tax expense	(292,722)	206,070
Income tax expense	1,183	2,662
Net income (loss)	$ (293,905)	$ 203,408
Earnings Per Share [Abstract]
Basic (in usd per share)	$ (3.41)	$ 2.66
Diluted (in usd per share)	$ (3.41)	$ 2.56
​Weighted average number of common shares outstanding
Basic (in shares)	86,158	76,457
Diluted (in shares)	86,158	80,711
Product sales
Revenue:
Revenues	$ (7,457)	$ 585,628
Grants
Revenue:
Revenues	87,379	99,301
Royalties and other
Revenue:
Revenues	$ 1,029	$ 19,042