Stock-Based Compensation - Schedule of Assumptions Used in Estimation of Fair Value of Stock (Details) - $ / shares	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Black-Scholes fair value (in usd per share)	$ 55.32	$ 158.02	$ 80.48
Risk-free interest rate, minimum	1.40%	0.50%	0.20%
Risk-free interest rate, maximum	4.30%	1.30%	1.50%
Dividend yield	0.00%	0.00%	0.00%
Volatility, minimum	120.50%	124.70%	116.00%
Volatility, maximum	140.10%	142.00%	152.20%
Options \| Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected term (in years)	4 years	4 years 1 month 6 days	3 years 10 months 24 days
Options \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected term (in years)	6 years 3 months 18 days	6 years 1 month 6 days	7 years 7 months 6 days
ESPP
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk-free interest rate, minimum	0.60%	0.10%	0.20%
Risk-free interest rate, maximum	3.30%	0.20%	2.60%
Dividend yield	0.00%	0.00%	0.00%
Volatility, minimum	103.00%	114.90%	66.60%
Volatility, maximum	142.90%	159.40%	189.70%
ESPP \| Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Black-Scholes fair value (in usd per share)	$ 23.59	$ 83.47	$ 2.57
Expected term (in years)	6 months	6 months	6 months
ESPP \| Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Black-Scholes fair value (in usd per share)	$ 79.74	$ 238.85	$ 92.67
Expected term (in years)	2 years	2 years	2 years

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(iii)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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- Definition

The estimated measure of the maximum percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

+ References

No definition available.

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- Definition

The estimated measure of the minimum percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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- Definition

The maximum risk-free interest rate assumption that is used in valuing an option on its own shares.

+ References

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- Definition

The minimum risk-free interest rate assumption that is used in valuing an option on its own shares.

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (d)(1)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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- Definition

Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(i)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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