Collaboration and License Agreements (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2022 USD ($) installment	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Sep. 30, 2021 dose	Feb. 28, 2021 dose
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development	$ 1,235,278	$ 2,534,508	$ 747,027
Takeda Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of doses to be distributed | dose				150,000,000
Milestone payment recognized	20,000		$ 20,000
SK Bioscience Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of doses to be distributed | dose					40,000,000
Settlement Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement payment	185,000
Initial reservation fee	$ 47,800
Number of quarterly installment payments | installment	4
Settlement agreement, quarterly installment amount	$ 34,300
Research and development	98,300
Settlement Agreement | Accrued Liabilities
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement payment	$ 137,200