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Other Financial Information
 12 Months Ended
Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Other Financial Information Other Financial Information
Prepaid Expenses and Other Current Assets
Prepaid expenses and other current assets consist of the following at December 31 (in thousands):
December 31,
20222021
Prepaid expenses$160,773 $120,029 
Other current assets76,374 44,619 
Prepaid expenses and other current assets$237,147 $164,648 
Property and Equipment, net
Property and equipment is comprised of the following at December 31 (in thousands):
December 31,
20222021
Land and buildings$101,342 $83,534 
Machinery and equipment134,809 119,998 
Leasehold improvements18,895 10,282 
Computer hardware4,927 2,612 
Construction in progress81,566 35,114 
341,539 251,540 
Less: accumulated depreciation(47,292)(25,799)
Property and equipment, net$294,247 $225,741 
As of December 31, 2022 and 2021, approximately $170.0 million and $164.0 million, respectively, of net assets used in operations were located in the Czech Republic. Depreciation expense was approximately $29.1 million, $12.5 million, and $4.3 million for the years ended December 31, 2022, 2021, and 2020, respectively.
Accrued Expenses
Accrued expenses consist of the following at December 31 (in thousands):
December 31,
20222021
Employee benefits and compensation$52,569 $38,419 
Research and development accruals468,214 577,100 
Other accrued expenses70,375 58,212 
Accrued expenses$591,158 $673,731 
Other Current Liabilities
Other current liabilities consist of the following at December 31 (in thousands):
December 31,
20222021
Refunds to customers$210,362 $— 
Other current liability related to Gavi (see Note 3 and Note 18)697,384 — 
Other current liabilities22,309 36,061 
Total other current liabilities$930,055 $36,061