Collaboration, License, and Supply Agreements (Details) $ in Thousands	3 Months Ended			9 Months Ended
	Sep. 30, 2022 USD ($) installment	Jun. 30, 2022 USD ($)	Sep. 30, 2021 USD ($)	Sep. 30, 2022 USD ($) installment	Sep. 30, 2021 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payment recognized		$ 20,000
Research and development	$ 304,297		$ 408,195	$ 977,428	$ 1,571,551
Settlement Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement payment	185,000			185,000
Initial reservation fee	$ 47,800			$ 47,800
Number of quarterly installment payments | installment	4			4
Settlement agreement, quarterly installment amount	$ 34,300			$ 34,300
Research and development	98,300			98,300
Settlement Agreement | Accrued Liabilities
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement payment	102,900			102,900
Settlement Agreement | Other Noncurrent Liabilities
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Settlement agreement, quarterly installment amount	$ 34,300			$ 34,300