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Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of stock-based compensation expense
The Company recorded all stock-based compensation expense in the consolidated statements of operations as follows (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2022202120222021
Cost of sales$51 $— $51 $— 
Research and development16,107 21,860 52,692 70,429 
General and administrative15,389 23,414 49,782 81,028 
Total stock-based compensation expense$31,547 $45,274 $102,525 $151,457 
Schedule of option and appreciation rights activity
The following is a summary of stock options and SARs activity under the 2015 Plan and 2005 Plan for the nine months ended September 30, 2022:
2015 Plan2005 Plan
Stock
Options		Weighted-Average
Exercise
Price		Stock
Options		Weighted-Average
Exercise
Price
Outstanding at December 31, 20213,635,837 $42.60 68,225 $109.52 
Granted558,181 71.21 — — 
Exercised(132,420)15.75 (3,000)31.10 
Canceled(61,364)88.58 (1,500)121.00 
Outstanding at September 30, 20224,000,234 $46.78 63,725 $112.94 
Shares exercisable at September 30, 20222,739,565 $39.72 63,725 $112.94 
Schedule of assumptions used in estimation of fair value of stock
The fair value of stock options granted under the 2015 Plan was estimated at the date of grant using the Black-Scholes option-pricing model with the following assumptions:
Three Months Ended
September 30,		Nine Months Ended
September 30,
2022202120222021
Weighted average Black-Scholes fair value of stock options granted
$37.66
$203.51
$60.24
$156.86
Risk-free interest rate
3.0%-3.6%
0.6%-0.9%
1.4%-3.6%
0.5%-1.1%
Dividend yield—%—%—%—%
Volatility
122.2%-136.4%
126.4%-140.0%
120.5%-136.7%
124.7%-142.0%
Expected term (in years)
4.0-5.3
4.1-6.1
4.0-6.3
4.1-6.1
The ESPP is considered compensatory for financial reporting purposes. As such, the fair value of ESPP shares was estimated at the date of grant using the Black-Scholes option-pricing model with the following assumptions:
Three Months Ended
September 30,		Nine Months Ended
September 30,
2022202120222021
Range of Black-Scholes fair values of ESPP shares granted
$23.59-$39.73
$83.47-$152.11
$23.59-$79.74
$83.47-$238.85
Risk-free interest rate
3.2%-3.3%
0.1%-0.2%
0.6%-3.3%
0.1%-0.2%
Dividend yield—%—%—%—%
Volatility
103.0%-114.8%
114.9%-150.6%
103.0%-142.9%
114.9%-159.4%
Expected term (in years)
0.5-2.0
0.5-2.0
0.5-2.0
0.5-2.0
Schedule of share based compensation restricted stock awards activity
The following is a summary of RSU activity for the nine months ended September 30, 2022:
Number of
Shares		Per Share
Weighted-
Average
Fair Value
Outstanding and unvested at December 31, 2021819,828 $116.70 
Granted1,113,958 68.49 
Vested(379,802)78.17 
Forfeited(114,976)110.59 
Outstanding and unvested at September 30, 20221,439,008 $90.03