CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue:
Revenues	$ 185,925	$ 298,017	$ 889,896	$ 745,246
Expenses:
Cost of sales	271,077	0	286,281	0
Research and development	289,648	570,685	673,131	1,163,356
Selling, general, and administrative	108,160	73,161	204,152	136,351
Total expenses	668,885	643,846	1,163,564	1,299,707
Income (loss) from operations	(482,960)	(345,829)	(273,668)	(554,461)
Other income (expense):
Interest expense	(6,234)	(5,968)	(11,110)	(10,807)
Other income (expense)	(19,873)	3,028	(18,219)	(3,203)
Income (loss) before income tax expense	(509,067)	(348,769)	(302,997)	(568,471)
Income tax expense	1,418	3,548	4,080	6,565
Net loss	$ (510,485)	$ (352,317)	$ (307,077)	$ (575,036)
Net income (loss) per share:
Basic (in usd per share)	$ (6.53)	$ (4.75)	$ (3.97)	$ (7.82)
​Weighted average number of common shares outstanding
Basic (in shares)	78,143	74,118	77,305	73,580
Product sales
Revenue:
Revenues	$ 55,455	$ 0	$ 641,083	$ 0
Grants
Revenue:
Revenues	107,774	272,489	207,075	719,382
Royalties and other
Revenue:
Revenues	$ 22,696	$ 25,528	$ 41,738	$ 25,864