CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenue:
Revenues	$ 703,971	$ 447,229
Expenses:
Cost of sales	15,204	0
Research and development	383,483	592,671
Selling, general, and administrative	95,992	63,190
Total expenses	494,679	655,861
Income (loss) from operations	209,292	(208,632)
Other income (expense):
Interest expense	(4,876)	(4,839)
Other income (expense)	1,654	(6,231)
Income (loss) before income tax expense	206,070	(219,702)
Income tax expense	2,662	3,017
Net income (loss)	$ 203,408	$ (222,719)
Net income (loss) per share:
Basic (in usd per share)	$ 2.66	$ (3.05)
Diluted (in usd per share)	$ 2.56	$ (3.05)
​Weighted average number of common shares outstanding
Basic weighted average number of common shares outstanding (in shares)	76,457	73,035
Diluted weighted average number of common shares outstanding (in shares)	80,711	73,035
Product sales
Revenue:
Revenues	$ 585,628	$ 0
Grants
Revenue:
Revenues	99,301	446,893
Royalties and other
Revenue:
Revenues	$ 19,042	$ 336