Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Federal and state net operating loss carryforward	$ 845,731	$ 325,655
Foreign net operating loss carryforward	25,625	8,620
Research tax credits	44,618	35,065
Lease liability	52,852	39,548
Deferred revenue	20,262	60,657
Non-cash stock-based compensation	24,698	22,577
Original discount interest	1,729	3,177
Other	11,801	12,019
Total deferred tax assets	1,027,316	507,318
Valuation allowance	(1,015,333)	(504,788)
Net deferred tax assets	11,983	2,530
Deferred tax liabilities:
ROU assets	(10,071)	(1,253)
Intangibles	(1,034)	(1,198)
Other	(878)	(79)
Total deferred tax liabilities	(11,983)	(2,530)
Net deferred tax assets	$ 0	$ 0