Income Taxes (Tables)

12 Months Ended

Dec. 31, 2020

Income Tax Disclosure [Abstract]

Schedule of Company's Loss from Operations Before Income Tax Expense by Jurisdiction

The Company’s loss from operations before income tax expense by jurisdiction for the years ended December 31 are as follows (in thousands):

	2020		2019		2018
Domestic	$	(455,253)	$	(124,189)	$	(176,290)
Foreign	36,994		(8,505)		(8,458)
Total net loss	$	(418,259)	$	(132,694)	$	(184,748)

Schedule of Tax Rate Differences

A reconciliation of the provision for income tax to the amount computed by applying the U.S. federal statutory tax rate to the Company’s effective tax rate is as follows:

	2020		2019		2018
Statutory federal tax rate	(21)	%	(21)	%	(21)	%
State income taxes, net of federal benefit	(3)	%	(2)	%	(3)	%
Research and development and other tax credits	—	%	(3)	%	(3)	%
Non-deductible expenses	4	%	—	%	—	%
Non-cash stock-based compensation	(7)	%	—	%	—	%
Other	1	%	1	%	1	%
Change in tax rate	(5)	%	3	%	5	%
Change in valuation allowance	31	%	22	%	21	%
Income tax provision	—	%	—	%	—	%

Schedule of Deferred Tax Assets (Liabilities)

(in thousands):

	2020		2019
Deferred tax assets:
Federal and State net operating loss carryforward	$	325,655	$	293,736
Foreign net operating loss carryforward	8,620		13,520
Research tax credits	35,065		37,066
Lease liability	39,548		2,164
Deferred revenue	60,657		973
Non-cash stock-based compensation	22,577		13,679
Original discount interest	3,177		4,326
Other	12,019		2,820
Total deferred tax assets	507,318		368,284
Valuation allowance	(504,788)		(365,772)
Net deferred tax assets	$	2,530	$	2,512
Deferred tax liabilities:
ROU assets	(1,253)		(1,033)
Intangibles	(1,198)		(1,279)
Other	(79)		(200)
Total deferred tax liabilities	$	(2,530)	$	(2,512)
Net deferred tax assets	$	—	$	—

Schedule of Unrecognized Tax Benefits Roll Forward

A reconciliation of the beginning and ending amounts of unrecognized tax benefits in the year ended December 31, 2020, 2019 and 2018 is as follows (in thousands):

	2020		2019		2018
Unrecognized tax benefits balance at January 1,	$	—	$	—	$	—
Additions for tax positions of current year	1,413		—		—
Additions for tax positions of prior years	7,353		—		—
Reductions for tax positions of prior year	—		—		—
Settlements of tax positions of prior years	—		—		—
Unrecognized tax benefits balance at December 31,	$	8,766	$	—	$	—