The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 315 3,500 SH Call DFND 1,2,3,4 3,500 0 0
ACCELERON PHARMA INC COM 00434H108 18,966 211,038 SH   DFND 1,2,3,4 211,038 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 15,719 1,164,343 SH   DFND 1,2,3,4 1,164,343 0 0
AKAZOO SA SHS L0164E108 868 310,000 SH   DFND 1,2,3,4 310,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 10,326 115,000 SH   DFND 1,2,3,4 115,000 0 0
ALLY FINL INC COM 02005N100 4,942 342,472 SH   DFND 1,2,3,4 342,472 0 0
ALPHABET INC CAP STK CL A 02079K305 20,468 17,615 SH   DFND 1,2,3,4 17,615 0 0
AMAZON COM INC COM 023135106 41,611 21,342 SH   DFND 1,2,3,4 21,342 0 0
ATHENEX INC COM 04685N103 28,762 3,715,960 SH   DFND 1,2,3,4 3,715,960 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 6,713 462,680 SH   DFND 1,2,3,4 462,680 0 0
BEYOND AIR INC COM 08862L103 4,088 511,036 SH   DFND 1,2,3,4 511,036 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 49,778 1,462,761 SH   DFND 1,2,3,4 1,462,761 0 0
CARA THERAPEUTICS INC COM 140755109 1,911 144,700 SH Call DFND 1,2,3,4 144,700 0 0
CARA THERAPEUTICS INC COM 140755109 6,366 481,883 SH   DFND 1,2,3,4 481,883 0 0
CENTENNIAL RESOURCE DEV INC CL A 15136A102 322 1,222,442 SH   DFND 1,2,3,4 1,222,442 0 0
CONSTELLIUM SE CL A SHS F21107101 11,607 2,227,925 SH   DFND 1,2,3,4 2,227,925 0 0
CROCS INC COM 227046109 5,068 298,306 SH   DFND 1,2,3,4 298,306 0 0
CROWN HLDGS INC COM 228368106 33,582 578,597 SH   DFND 1,2,3,4 578,597 0 0
DISNEY WALT CO COM DISNEY 254687106 1,836 19,008 SH   DFND 1,2,3,4 19,008 0 0
DISNEY WALT CO COM DISNEY 254687106 5,033 52,100 SH Call DFND 1,2,3,4 52,100 0 0
EXICURE INC COM 30205M101 502 339,395 SH   DFND 1,2,3,4 339,395 0 0
FACEBOOK INC CL A 30303M102 5,972 35,803 SH   DFND 1,2,3,4 35,803 0 0
FACEBOOK INC CL A 30303M102 13,811 82,800 SH Call DFND 1,2,3,4 82,800 0 0
FLEXION THERAPEUTICS INC COM 33938J106 7,001 889,578 SH   DFND 1,2,3,4 889,578 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 1,224 711,552 SH   DFND 1,2,3,4 711,552 0 0
GREAT ELM CAP GROUP INC COM NEW 39036P209 2,342 1,259,049 SH   DFND 1,2,3,4 1,259,049 0 0
GTY TECHNOLOGY HOLDINGS INC COM 362409104 5,241 1,159,600 SH   DFND 1,2,3,4 1,159,600 0 0
HOME DEPOT INC COM 437076102 15,495 82,987 SH   DFND 1,2,3,4 82,987 0 0
IAA INC COM 449253103 14,041 468,673 SH   DFND 1,2,3,4 468,673 0 0
IQIYI INC SPONSORED ADS 46267X108 15,430 866,862 SH   DFND 1,2,3,4 866,862 0 0
KANSAS CITY SOUTHERN COM NEW 485170302 11,612 91,300 SH   DFND 1,2,3,4 91,300 0 0
MERCK & CO. INC COM 58933Y105 18,735 243,500 SH Call DFND 1,2,3,4 243,500 0 0
MICROSOFT CORP COM 594918104 11,362 72,046 SH   DFND 1,2,3,4 72,046 0 0
MIMECAST LTD ORD SHS G14838109 14,033 397,524 SH   DFND 1,2,3,4 397,524 0 0
MOLECULAR TEMPLATES INC COM 608550109 8,971 674,990 SH   DFND 1,2,3,4 674,990 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 11,465 617,749 SH   DFND 1,2,3,4 617,749 0 0
PTC THERAPEUTICS INC COM 69366J200 11,230 251,734 SH   DFND 1,2,3,4 251,734 0 0
PURPLE INNOVATION INC COM 74640Y106 3,199 563,230 SH   DFND 1,2,3,4 563,230 0 0
RAPID7 INC COM 753422104 12,140 280,171 SH   DFND 1,2,3,4 280,171 0 0
SALESFORCE COM INC COM 79466L302 3,170 22,020 SH   DFND 1,2,3,4 22,020 0 0
SCYNEXIS INC COM 811292101 2,086 2,670,487 SH   DFND 1,2,3,4 2,670,487 0 0
SEA LTD SPONSORED ADS 81141R100 4,287 96,758 SH   DFND 1,2,3,4 96,758 0 0
SESEN BIO INC COM 817763105 981 1,749,219 SH   DFND 1,2,3,4 1,749,219 0 0
SIMPLY GOOD FOODS CO COM 82900L102 10,525 546,481 SH   DFND 1,2,3,4 546,481 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 5,856 829,500 SH   DFND 1,2,3,4 829,500 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 10,235 192,173 SH   DFND 1,2,3,4 192,173 0 0
TEMPUR SEALY INTL INC COM 88023U101 10,240 234,260 SH   DFND 1,2,3,4 234,260 0 0
TREX CO INC COM 89531P105 14,927 186,261 SH   DFND 1,2,3,4 186,261 0 0
TRILOGY METALS INC NEW COM 89621C105 2,072 1,523,461 SH   DFND 1,2,3,4 1,523,461 0 0
VEEVA SYS INC CL A COM 922475108 7,624 48,759 SH   DFND 1,2,3,4 48,759 0 0
VERTIV HOLDINGS CO COM CL A 92537N108 14,147 1,635,487 SH   DFND 1,2,3,4 1,635,487 0 0
WILLSCOT CORP COM 971375126 8,015 791,259 SH   DFND 1,2,3,4 791,259 0 0