EXHIBIT 10.1

INTERNATIONAL STEM CELL CORPORATION

PROMISSORY NOTE

FOR VALUE RECEIVED, and subject to the terms and conditions set forth herein, on this 31st day of May, 2018 (the “Issuance Date”), International Stem Cell Corporation, a Delaware corporation, with offices located at 5950 Priestly Drive, Carlsbad, CA 92008 (the “Borrower”), hereby unconditionally promises to pay to the order ofAndrey Semechkin or his assigns (the “Noteholder”), the principal amount of one million and one hundred thousand dollars ($1,100,000) (the “Loan”), together with all accrued interest thereon, as provided in this Promissory Note (the “Note”).

1.Previous Note. On May 14, 2018 the Noteholder was issued a Promissory Note in the principal amount of eight hundred thousand dollars ($800,000) by the Borrower (the “Original Note”). On May 31st, 2018 the Noteholder agreed to provide an additional three hundred thousand dollars ($300,000) of funds to the Borrower and surrendered the Original Note, in return for which the Noteholder was issued this Note.

2.Payment Terms.

2.1 Final Payment Date. The aggregate unpaid principal amount of the Loan and all accrued and unpaid interest shall be due and payable on November 1, 2018 (the “Maturity Date”).

2.2Optional Prepayment. The Borrower may prepay the Loan, in whole or in part, at any time or from time to time, without penalty or premium by paying the principal amount to be prepaid together with accrued interest thereon to the date of prepayment.

3.Interest.

3.1Interest Rate. The outstanding principal amount of the Loan made hereunder shall bear interest at the annual rate of four percent (4%) from the date on which the Loan proceeds are received by the Borrower until the Loan is paid in full, whether at maturity, by prepayment or otherwise.

3.2Interest Payment Dates. Interest shall be payable on maturity, or earlier with respect to any prepayment.

3.3Computation of Interest. All computations of interest shall be made on the basis of a year of 360 days and the actual number of days elapsed. Interest shall accrue on the Loan on the day on which the proceeds of such Loan are received by the Borrower, and shall not accrue on the Loan (or any portion thereof) for the day on which the Loan is paid.

3.4Interest Rate Limitation. If at any time and for any reason whatsoever, the interest rate payable on the Loan shall exceed the maximum rate of interest permitted to be charged

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by the Noteholder to the Borrower under applicable law, such interest rate shall be reduced automatically to the maximum rate of interest permitted to be charged under applicable law, and that portion of any sum paid attributable to that portion of such interest rate that exceeds the maximum rate of interest permitted by applicable law shall be deemed a voluntary prepayment of principal.

4.Payment Mechanics. All payments of principal and interest shall be made in lawful money of the United States of America by check or by wire transfer of immediately available funds to the Noteholder’s account at a bank specified by the Noteholder in writing to the Borrower from time to time.

5.Governing Law. This Note and any claim, controversy, dispute or cause of action based upon, arising out of or relating to this Note, and the transactions contemplated hereby, shall be governed by the laws of the State of California.

IN WITNESS WHEREOF, the Borrower has executed this Note as of the Issuance Date written above.

BORROWER NOTEHOLDER

International Stem Cell Corporation Andrey Semechkin

SignatureDATESignatureDATE

Sophia D. Garnette

VP Legal Affairs & Operations

May 31, 2018

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