Composite Indenture

U.S. BANK NATIONAL ASSOCIATION, not in its
individual capacity but solely as Trustee

Authorized Signatory

INDENTURE, dated as of December 22, 2004 (this “Indenture”), by and between CINACALCET ROYALTY SUB LLC, a Delaware limited liability company, as issuer of the Notes (the “Issuer”), and U.S. BANK NATIONAL ASSOCIATION, a national banking association, as initial trustee of the Notes (the “Trustee”).

NOW, THEREFORE, THIS INDENTURE WITNESSETH, that, in consideration of the premises and the acceptance by the Trustee of the trusts hereby created and of the purchase and acceptance of the Notes by the Noteholders, and for other good and valuable consideration, the receipt of which is hereby acknowledged, in order to secure (i) the prompt payment of the principal of, Premium (if any) and interest on, and all other amounts due with respect to, the Notes from time to time outstanding hereunder, including, without limitation, any break funding costs and interest rate swap breakage costs; (ii) payment of any fees, expenses or other amounts that the Issuer is obligated to pay under or in respect of the Notes, this Indenture or any Related Document; (iii) the payment and performance of all the obligations of the Issuer in respect of any amendment, modification, extension, renewal or refinancing of the Notes; and (iv) the performance and observance by the Issuer of all the agreements, covenants and provisions expressed or implied herein and in the Notes for the benefit of the Noteholders (collectively, the “Secured Obligations”) and for the uses and purposes and subject to the terms and provisions hereof, the Issuer does hereby grant, bargain, sell, assign, transfer, convey, mortgage, pledge and confirm unto the Trustee, its successors and assigns, for the security and benefit of the Noteholders and any other holders from time to time of the Notes, a first priority security interest in all right, title and interest of the Issuer in, to and under the following described property, rights and privileges (each property, including all other property hereafter specifically subjected to the lien of this Indenture or any indenture supplemental hereto, being the “Collateral” and, collectively, including all other property hereafter specifically subjected to the lien of this Indenture or any indenture supplemental hereto, are included within and defined as the “Indenture Estate”), to wit:

(1) The Royalty Rights (but excluding the Quarterly Statement Rights, the Audit Rights and all Confidential Information) and, if acquired by the Issuer, any and all rights in the Licensed Technology;

(2) The rights of the Issuer in respect of the obligations of NPS to sell, contribute and sublicense, as applicable, the Licensed Technology to the Issuer on the Termination Date

(3) The Purchase and Sale Agreement and all other agreements to which the Issuer is a party relating to the rights of the Issuer in respect of the transfer and servicing of the Royalty Rights and, if acquired by the Issuer, the Licensed Technology;

(5) (A) The Interest Reserve Account and all other Accounts established under the Indenture at any time established, (B) all amounts from time to time credited to such Accounts, (C) all cash, financial assets and other investment property, instruments, documents, chattel paper, general intangibles, accounts and other property from time to time credited to such accounts or representing investments and reinvestments of amounts to such Accounts, (D) all interest, principal payments, dividends and other distributions payable on or with respect to, and all proceeds of, (i) all property so credited or representing such investments and reinvestments and (ii) such Accounts;

(6) all rents, issues, profits, revenues and other income of the property subjected or required to be subjected to the lien of this Indenture;

(7) all other general intangibles, instruments, investment property, and documents of the Issuer;

(8) all rights (contractual and otherwise and whether constituting accounts, general intangibles or investment property or financial assets) constituting, arising under, connected with, or in any way related to, any or all of the foregoing property;

(9) all books, records, ledger cards, files, correspondence, computer programs, tapes, disks and related data processing software (owned by the Issuer) that at any time evidence or contain information relating to any of the foregoing property or are otherwise necessary or helpful in the collection thereof or realization thereupon;

(10) all documents of title, policies and certificates of insurance, securities, chattel paper and other documents or instruments evidencing or pertaining to any of the foregoing property; and

BUT EXCLUDING from the foregoing and from the Collateral and the Indenture Estate the Audit Rights, the Quarterly Statement Rights and all Confidential Information, and SUBJECT TO all of the terms and conditions of this Indenture;

TO HAVE AND TO HOLD all and singular the aforesaid property unto the Trustee, its successors and assigns, in trust for the benefit and security of the Noteholders and any other Holders from time to time of each class of the Notes, without any priority of any one class of Notes over any other class of Notes by reason of difference in time of issuance or otherwise, except as expressly provided herein, and for the uses and purposes and subject to the terms and provisions set forth in this Indenture.

PROVIDED, HOWEVER, that notwithstanding any of the foregoing provisions or anything to the contrary herein, so long as no Event of Default shall have occurred and be continuing, the Issuer shall have the right, to the exclusion of the Trustee and the Noteholders, to exercise in the Issuer’s name all rights and powers of the Issuer under the Purchase and Sale Agreement, SUBJECT TO all of the terms and conditions of this Indenture;

It is expressly agreed that anything herein contained to the contrary notwithstanding, the Issuer shall remain liable under the Related Documents to perform all of the obligations assumed by it thereunder in accordance with and pursuant to the terms and provisions thereof, and, prior to the foreclosure of the lien of this Indenture, the Trustee and the Holders of the Notes shall have no obligation or liability under any thereof by reason of or arising out of the assignment hereunder, nor shall the Trustee or the Holders of the Notes be required or obligated in any manner to perform or fulfill any obligations of the Issuer under or pursuant to any Related Document or, except as herein expressly provided, to make any payment, or to make any inquiry as to the nature or sufficiency of any payment received by it, or present or file any claim, or take any action to collect or enforce the payment of any amounts which may have been assigned to it or to which it may be entitled at any time or times; provided, however, that in exercising any right of the Issuer under any Related Document, the Trustee and the Holders of the Notes shall be bound by, and comply with, the provisions thereof applicable to the Issuer.

The Issuer does hereby constitute the Trustee the true and lawful attorney of the Issuer, irrevocably, granted for good and valuable consideration and coupled with an interest and with full power of substitution, and with full power (in the name of the Issuer or otherwise), to ask, require, demand, receive, compound and give acquittance for any and all monies and claims for monies (in each case including insurance and requisition proceeds) due and to become due under or arising out of any Related Document and all other property which now or hereafter constitutes part of the Indenture Estate, to endorse any checks or other instruments or orders in connection therewith and to file any claims or take any action or institute any proceedings which the Trustee may deem to be necessary or advisable in the premises; provided that the Trustee shall not exercise any such rights except upon the occurrence and during the continuance of an Event of Default hereunder.

The Issuer agrees that at any time and from time to time, upon written request of the Trustee, the Issuer will promptly and duly execute and deliver or cause to be duly executed and delivered any and all such further instruments and documents as the Trustee may reasonably deem desirable in obtaining the full benefits of the assignment hereunder and of the rights and powers herein granted.

The Issuer does hereby: (a) warrant and represent that it has not assigned or pledged, and (b) covenant that it will not assign or pledge, so long as the assignment hereunder shall remain in effect and has not been terminated pursuant to Section 11.01 herein, any of its right, title or interest hereby assigned, to anyone other than the Trustee.

It is hereby further agreed that any and all property described or referred to in the granting clauses hereof which is hereafter acquired by the Issuer shall ipso facto, and without any other conveyance, assignment or act on the part of the Issuer or the Trustee, become and be subject to the Security Interest herein granted as fully and completely as though specifically described herein, but nothing contained in this paragraph shall be deemed to modify or change the obligations of the Issuer contained in the foregoing paragraphs.

Except where the context clearly indicates a different meaning all terms defined in Article 1, 8 or 9 of the UCC, as in effect on the date of this Indenture, are used in this Granting Clause with the meanings therein ascribed to them; such terms include “document”, “general intangibles”, “instrument”, “investment property”, “proceeds” and “security interest”. In addition, all capitalized terms used in this Granting Clause, including the terms “account” and “security interest”, when capitalized, shall have the meanings specified in Section 1.01 below.

The Issuer does hereby ratify and confirm the other Related Documents to which it is a party and, subject to the other terms of this Indenture, does hereby agree that it will not take or omit to take any action, the taking or omission of which might result in an alteration or impairment of the assignment hereunder or of any of the rights created by any thereof.

IT IS HEREBY COVENANTED AND AGREED by and between the parties hereto as follows:

Section 1.01 Definitions. For purposes of this Indenture, the following terms shall have the meanings indicated below:

“Acceleration Default” means any Event of Default of the type described in Section 4.01(e) or 4.01(f) hereof.

“Acceleration Notice” means a notice given after the occurrence of an Event of Default to the Issuer by the Senior Trustee at the instruction of the Noteholders representing a majority of the aggregate Outstanding Principal Balance of the Senior Class of Notes, with a copy to NPS, declaring all Outstanding principal of and accrued and unpaid interest on the Notes to be immediately due and payable.

“Accounts” means the Collection Account, the Interest Reserve Account and any Redemption Account.

“Act” has the meaning, with respect to any Noteholder, given to such term in Section 1.04 hereof.

“Actual Annual Net Sales Percentage” means, as of any Payment Date, the ratio, expressed as a percentage, rounded to four decimal places, of (x) the net sales of Cinacalcet during the four full calendar quarters immediately preceding the quarter in which such Payment Date occurs, as reported by Amgen in the statements for such calendar quarters delivered pursuant to Section 7.6(A) of the License Agreement, to (y) the sum of the amounts for the same four quarters set forth on Appendix B.

“Additional Interest” means, with respect to the Notes, interest accrued on the amount of any interest and Premium, if any, in respect of such Notes that is not paid when due at the Stated Rate of Interest of such Notes for each Interest Accrual Period until any such unpaid interest or Premium is paid in full, to the fullest extent permitted by Applicable Law.

“Affiliate” means, with respect to any Person, any other Person that, directly or indirectly, controls, is controlled by or is under common control with, such Person or is a director or officer of such Person; “control” of a Person means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of such Person, whether through the ownership of voting Stock, by contract or otherwise.

“Amgen Payment” means (i) any payment by Amgen of an NPS obligation, including a B&W Royalty that is offset against the amount of the Royalty Payments due from Amgen to the Issuer, and (ii) any offset by Amgen against the amount of such Royalty Payments in respect of any obligation of NPS to Amgen.

“Applicable Law” means, with respect to any Person, all laws, rules, regulations and orders of governmental regulatory authorities applicable to such Person or any of its properties or assets.

“Audit Rights” means the right to appoint an independent certified public accountant and receive a report therefrom under Section 7.6(C) of the License Agreement.

“Authorized Agent” means, with respect to the Notes, any authorized Paying Agent or Registrar for such Notes.

“Available Collections Amount” means, as of any Payment Date, the total of (a) the amount on deposit in the Collection Account as of the Calculation Date immediately preceding such Payment Date, (b) the amount of the investment earnings on amounts in the Interest Reserve Account as of such Calculation Date, and (c) in respect of any Payment Date on or prior to December 30, 2006, the amount, if any, withdrawn from the Interest Reserve Account on such Payment Date pursuant to Section 3.04(b) or Section 3.07(a).

“Base Case Amortization Schedule” means the 100% Base Case Amortization Schedule set forth in the Private Placement Memorandum.

“Base Case Final Payment Date” means for any Refinancing Notes or Class B Notes, if applicable, the date specified in the indenture supplement and/or Board Resolution providing for their issuance.

“Basic Terms Modification” has the meaning given to such term in Section 9.01 hereof.

“Beneficial Holder” means any Person that holds a Beneficial Interest in any Global Note through an Agent Member.

“Beneficial Interest” means any beneficial interest in any Global Note, whether held directly by an Agent Member or held indirectly through an Agent Member’s Beneficial Interest in such Global Note.

“Board” means the Managers of the Issuer, including the Independent Manager.

“Board Resolution” means a copy of a resolution certified by a Manager (other than the Independent Manager) as having been duly adopted by the Board and being in full force and effect on the date of such certification.

“Business Day” means any day except a Saturday, Sunday or other day on which commercial banks in New York, New York are authorized or required by law or executive order to remain closed or a day on which the Corporate Trust Office is closed for business and, for purposes of calculating LIBOR, a day on which dealings in deposits in U.S. dollars are transacted, or with respect to any future date are expected to be transacted, in the London interbank market.

“B&W” means The Brigham and Women’s Hospital, Inc., a Massachusetts not-for-profit corporation.

“B&W Agreement” means the Patent Agreement, effective February 19, 1993, between B&W and NPS, as amended, restated or supplemented from time to time.

“B&W/Amgen Interest” means the amount of interest payable as a result of the increase in the Stated Interest Rate on the Class A Notes pursuant to the first sentence of the last paragraph of Section 2.01(b).

“B&W Payment” means any payment made by the Trustee in respect of any B&W Shortfall.

“B&W Royalty” means the amount payable by NPS to B&W as a royalty related to the Licensed Technology pursuant to the B&W Agreement.

“B&W Shortfall” means the amount, if any, of the B&W Royalty that is due and payable but that has not been paid by NPS as of any Calculation Date.

“B&W Sublicense” means a sublicense from NPS to the Issuer of the exclusive license granted by B&W to NPS under the B&W Agreement relating to claims otherwise included in the Licensed Technology.

“Calculation Agent” means US Bank and any successor appointed as Calculation Agent pursuant to Section 6.11.

“Calculation Date” means, for any Payment Date, the fifth Business Day immediately preceding such Payment Date.

“Cash Sweep Payment Percentage” means the following percentage, rounded to four decimal places, based on the Actual Annual Net Sales Percentage for the applicable March 30 Payment Date:

(a) if the Actual Annual Net Sales Percentage for such March 30 Payment Date is equal to or less than 80%, the Cash Sweep Payment Percentage is 100%;

(b) if the Actual Annual Net Sales Percentage for such March 30 Payment Date is greater than 80% but less than 100%, the Cash Sweep Payment Percentage is equal to the sum of (x) 100% plus (y) the product of (i) 2.074 and (ii) the excess of such Actual Annual Net Sales Percentage over 80%; and

(c) if the Actual Annual Net Sales Percentage for such March 30 Payment Date is equal to or greater than 100%, the Cash Sweep Payment Percentage is 141.48%.

“Cash Sweep Premium” is, for any March 30 Payment Date, equal to the excess, if any, of the Net Available Collections Amount for such March 30 Payment Date over the Cash Sweep Principal Amount for such March 30 Payment Date.

“Cash Sweep Principal Amount” is, for any March 30 Payment Date, equal to the quotient of (x) the Net Available Collections Amounts for such March 30 Payment Date, divided by (y) the Cash Sweep Payment Percentage.

“Class B Issuance” has the meaning given to such term in Section 2.16(a) hereof.

“Class A Notes” means the Class A Notes, due March 30, 2017, of the Issuer in the initial Outstanding Principal Balance of $175,000,000, substantially in the form of Exhibit A hereto, and any Refinancing Notes issued to refinance the Class A Notes.

“Class B Notes” means the Class B Notes, if any, issued in such form as shall be authorized by a Board Resolution and any supplemental indenture in respect thereof and any Refinancing Notes issued to refinance the Class B Notes.

“Collaborative Agreements” means the B&W Agreement, the Collaborative Research and License Agreement dated as of June 30, 1995, between NPS and Kirin Brewery Company, Limited (“Kirin”), as amended, restated or supplemented from time to time (the “Kirin Agreement”); and the Collaborative Research and License Agreement dated as of November 1, 1993, between NPS and GlaxoSmithKline plc (“GSK”, as successor to SmithKline Beecham Corporation), as amended, restated or supplemented from time to time (the “GSK Agreement”);

“Collateral” has the meaning given to such term in the Granting Clause herein.

“Collection Account” has the meaning given to such term in Section 3.01(a) hereof.

“Collections” means, without duplication, (i) Royalty Payments; (ii) any Milestone Payment; (iii) any Hedge Receipts; (iv) any amount withdrawn from the Interest Reserve Account pursuant to Section 3.04(b) and

Section 3.07(a), (v) reimbursement by NPS of any B&W Payment or Amgen Payment and B&W/Amgen Interest, (vi) investment income, if any, on all amounts on deposit in the Accounts and (vii) any other amounts received by the Issuer (other than the proceeds of the Class A Notes, any Class B Notes and any Refinancing Notes).

“Confidential Information” means any and all information provided by Amgen or NPS in respect of the License Agreement and the Licensed Technology that is “Confidential Information,” as defined in the License Agreement.

“Confidentiality Agreement” means a Confidentiality Agreement substantially in the form of Exhibit N attached hereto.

“control” has the meaning given to such term in the definition of “Affiliate,” and the terms “controlling” and “controlled” have meanings correlative to the foregoing.

“Controlling Party” means the Person entitled to act as such pursuant to the terms of Section 4.13 hereof.

“Corporate Trust Office” means, with respect to the Trustee, the office of such trustee in the city at which at any particular time its corporate trust business shall be principally administered and, with respect to the Trustee on the date hereof, shall be Mail Code EP-MN-WS3C, 60 Livingston Avenue, St. Paul, Minnesota 55107, Attention: Corporate Trust Department, Facsimile No: (651) 495-8097.

“Default” means a condition, event or act which, with the giving of notice or the lapse of time or both, would constitute an Event of Default, provided that a failure to pay interest on the Class A Notes when such amount becomes due on any Payment Date other than the Final Maturity Date does not constitute a “Default,” provided further that a failure to pay any such interest not so paid on any such Payment Date in full with Additional Interest thereon by the next succeeding Payment Date shall be an immediate Event of Default, unless waived as provided in Section 4.05 .

“Definitive Notes” has the meaning given to such term in Section 2.01(b) hereof.

“Distribution Report” has the meaning given to such term in Section 2.13(a) hereof.

“DTC” means The Depository Trust Company, its nominees and their respective successors.

“Eligibility Requirements” has the meaning given to such term in Section 2.03(b) hereof.

“Eligible Account” means a trust account maintained on the books and records of an Eligible Institution in the name of the Trustee under and as defined herein.

“Eligible Institution” means any bank organized under the laws of the U.S. or any state thereof, or the District of Columbia (or any domestic branch of a foreign bank), which at all times has either (A) a long-term unsecured debt rating of A2 or better by Moody’s and A or better by Fitch and S&P or (B) a certificate of deposit rating of P-1 by Moody’s, A-1 by S&P and F1 by Fitch.

“Eligible Investments” means, in each case, book-entry securities, negotiable instruments or securities represented by instruments in bearer or registered form which evidence:

(a) direct obligations of, and obligations fully guaranteed as to timely payment of principal and interest by, the U.S. or any agency or instrumentality thereof the obligations of which are backed by the full faith and credit of the U.S. (having original maturities of no more than 365 days, or such lesser time as is required for the distribution of funds);

(b) demand deposits, time deposits or certificates of deposit of the Operating Bank or of depositary institutions or trust companies organized under the laws of the U.S. or any state thereof, or the

District of Columbia (or any domestic branch of a foreign bank) (i) having original maturities of no more than 365 days, or such lesser time as is required for the distribution of funds; provided that at the time of investment or contractual commitment to invest therein, the short-term debt rating of such depository institution or trust company shall be at least “F1” by Fitch, “P-1” by Moody’s and “A-1” by S&P or (ii) having maturities of more than 365 days and, at the time of the investment or contractual commitment to invest therein, a rating of at least “A2” from Moody’s and “A” from Fitch and S&P;

(c) corporate or municipal debt obligations (i) having remaining maturities of no more than 365 days or such lesser time as is required for the distribution of funds and having, at the time of the investment or contractual commitment to invest therein, a rating of at least “F1” or “A” by Fitch, “P-1” or “A2” by Moody’s and “A-1” or “A” by S&P or (ii) having maturities of more than 365 days and, at the time of the investment or contractual commitment to invest therein, a rating of at least “A2” from Moody’s and “A” from Fitch and S&P;

(d) investments in money market funds (including funds in respect of which the Trustee or any of its Affiliates is investment manager or otherwise) having a rating of at least “A” by Fitch and “A2” by Moody’s; or

(e) notes or bankers’ acceptances (having original maturities of no more than 365 days, or such lesser time as is required for the distribution of funds) issued by any depositary institution or trust company referred to in (b) above;

provided, however, that no investment shall be made in any obligations of any depositary institution or trust company that is identified in a written notice to the Trustee from the Issuer or the Servicer as having a contractual right to set off and apply any deposits held, and other indebtedness owing, by the Issuer to or for the credit or the account of such depository institution or trust company.

“Encumbrance” means any mortgage, pledge, lien, charge, security interest or other encumbrance, including, without limitation, any conditional sale, any sale with recourse against the Issuer, or any agreement to give any security interest.

“Euroclear” means Euroclear Bank S.N./N.V., as operator of the Euroclear System.

“Event of Default,” with respect to a class of Notes, has the meaning given to such term in Section 4.01 hereof.

“Expenses” means, with respect to the Issuer, any fees, costs or expenses of the Issuer, including, without limitation, the fees and expenses of the Trustee and the Service Providers, any commitment fee payable to a Hedge Provider, and any payments under indemnity obligations of the Issuer to any Person other than NPS; provided, however, that, except as expressly provided herein, Expenses shall not include any Transaction Expenses, any amount payable on the Notes, any Hedge Payments or Hedge Breakage Costs or any other amounts ranking pari passu with or junior to interest payable on the Class A Notes in the priority of payments set forth under Section 3.07 of this Indenture.

“Final Maturity Date” means, with respect to, (i) the Class A Notes, March 30, 2017, and (ii) with respect to any Class B Notes or any Refinancing Notes, the date specified in the Indenture Supplement providing for their issuance.

“Fitch” means Fitch, Inc., and any successor thereto, or, if such corporation or its successor shall for any reason no longer perform the functions of a securities rating agency, “Fitch” shall be deemed to refer to any other nationally recognized rating agency designated by the Issuer and meeting the definition of “nationally recognized statistical rating organization,” as set forth in the rules promulgated under the Exchange Act.

“Fixed Rate Notes” means the Class A Notes and any Class B Notes or Refinancing Notes issued with a fixed rate of interest.

“Floating Rate Bonds” means any Class B Notes and Refinancing Notes issued with a floating or variable rate of interest.

“Global Notes” means any Permanent Global Notes and Regulation S Global Notes.

“guarantee” means any obligation, contingent or otherwise, of any Person directly or indirectly guaranteeing any Indebtedness or other obligation of any other Person and, without limiting the generality of the foregoing, any obligation, direct or indirect, contingent or otherwise, of such Person (i) to purchase or pay (or advance or supply funds for the purchase or payment of) such Indebtedness or other obligation of such other Person or (ii) entered into for purposes of assuring in any other manner the obligee of such Indebtedness or other obligation of the payment thereof or to protect such obligee against loss in respect thereof (in whole or in part); provided that the term “guarantee” shall not include endorsements for collection or deposit in the ordinary course of business. The term “guarantee” when used as a verb has a corresponding meaning.

“Hedge Agreement” means any interest rate hedge, cap, floor, swap option, or other interest rate hedging agreement among the Issuer and any Hedge Provider existing on the Closing Date or entered into in accordance with Sections 5.02(g) of this Indenture.

“Hedge Breakage Costs” means any amounts payable by the Issuer to a Hedge Provider as a result of any early termination (however described or defined therein) of any Hedge Agreement.

“Hedge Payment” means, on the funding date for any Notes or on any Payment Date, a net payment to a Hedge Provider by the Issuer, but not including Hedge Breakage Costs.

“Hedge Provider” means the counterparty of the Issuer under any Hedge Agreement.

“Hedge Receipt” means a net payment to be made by a Hedge Provider into the Collection Account under a Hedge Agreement and includes any termination payment received from any counterparty to a Hedge Agreement.

“Indebtedness” means, with respect to any Person at any date of determination (without duplication), (i) all indebtedness of such Person for borrowed money, (ii) all obligations of such Person evidenced by bonds, debentures, notes or other similar instruments, (iii) all obligations of such Person in respect of letters of credit or other similar instruments (including reimbursement obligations with respect thereto), (iv) all the obligations of such Person to pay the deferred and unpaid purchase price of property or services, which purchase price is due more than six months after the date of purchasing such property or service or taking delivery and title thereto or the completion of such services, and payment deferrals arranged primarily as a method of raising funds to acquire such property or service, (v) all obligations of such Person under a lease of (or other agreement conveying the right to use) any property (whether real, personal or mixed) that is required to be classified and accounted for as a capital lease obligation under U.S. GAAP, (vi) all Indebtedness (as defined in clauses (i) through (v) of this paragraph) of other Persons secured by a lien on any asset of such Person, whether or not such Indebtedness is assumed by such Person, and (vii) all Indebtedness (as defined in clauses (i) through (v) of this paragraph) of other Persons guaranteed by such Person.

“Indenture Estate” has the meaning given to such term in the Granting Clause of this Indenture.

“Independent Manager” means a Manager of the Issuer who is not at the time of such person’s appointment as a Manager and who is not, and who has not been at any time during the preceding five (5) years: (i) a director, manager, officer or employee of the Issuer (other than in the capacity of Independent Manager) or any Affiliate of the Issuer (other than in the capacity of Independent Manager), (ii) a person related to any officer, director, manager

or employee of the Issuer (other than in the capacity of Independent Manager) or any Affiliate of the Issuer(other than in the capacity of Independent Manager), (iii) a holder (directly or indirectly) of any voting securities of the Issuer or any Affiliate of the Issuer, (iv) a person related to a holder (directly or indirectly) of any voting securities of the Issuer or any Affiliate of the Issuer, (v) a purchaser, customer or any other Person who derives any of its revenues from interactions with the Issuer or any Affiliate of the Issuer or a family member of such purchaser, customer of other Person; (vi) a trustee in bankruptcy or other insolvency proceedings for, or a reorganization of, NPS or any subsidiary or Affiliate of NPS.

“Institutional Accredited Investor” means a Person that is an “accredited investor” as that term is defined in Rule 501(a)(1), (2), (3) or (7) under the Securities Act.

“Intercompany Servicing Agreement” means the agreement between the Company and Seller, dated as of December 22, 2004, as amended, restated, supplemented or otherwise modified from time to time.

“Interest Accrual Period” means the period beginning on (and including) the relevant Closing Date and ending on (but excluding) the first Payment Date thereafter and each successive period beginning on (and including) a Payment Date and ending on (but excluding) the next succeeding Payment Date; provided, however, that the final Interest Accrual Period shall end on but exclude the Final Maturity Date (or, if earlier, with respect to any class of Notes repaid in full, the date such class of Notes is repaid in full).

“Interest Amount” means, with respect to each class of Notes, on any Payment Date, the amount of accrued and unpaid interest at the Stated Rate of Interest with respect to such class of Notes on such Payment Date (including any Additional Interest, if any), determined in accordance with the terms thereof.

“Interest Reserve Account” has the meaning given to such term in Section 3.01(a) hereof.

“Interest Reserve Account Balance” means, as of any Calculation Date, the then outstanding balance of the Interest Reserve Account.

“Interest Reserve Available Amount” means, as of any Calculation Date, the Interest Reserve Account Balance.

“LIBOR” means, with respect to each Interest Accrual Period, unless otherwise specified, the London interbank offered rate for deposits in U.S. dollars having a term of three-months for a period commencing on the second Business Day immediately following the Reference Date for such Interest Accrual Period in amounts of not less than $1,000,000, as such rate appears on Page 3750 on Moneyline Telerate (or such other page as may replace the 3750 page on that service or such other service as may be nominated by the British Bankers’ Association for the purpose of displaying London interbank offered rates for U.S. dollar deposits, “Telerate Page 3750”) at approximately 11:00 a.m. (London time) on such Reference Date therefor; provided that if three-month LIBOR cannot be determined from Telerate Page 3750, the Calculation Agent shall request the principal London offices of each of four major banks in the London interbank market selected by the Calculation Agent to provide a quotation of the rate (the “Rate Quotation”) at which three-month deposits in amounts of not less than $1,000,000 are offered by it to prime banks in the London interbank market, at approximately 11:00 a.m. London time on such Reference Date, that is representative of single transactions at such time (the “Representative Amounts”), and if at least two Rate Quotations are provided, three-month LIBOR will be the arithmetic mean of the Rate Quotations obtained by the Calculation Agent; provided, further, that in the event three-month LIBOR cannot be determined from Telerate Page 3750 as described herein and fewer than two Rate Quotations are available, three-month LIBOR will be the arithmetic mean of the rates quoted at approximately 11:00 a.m. New York City time on such Reference Date, by three major banks in New York City, selected by the Calculation Agent, for loans in Representative Amounts in U.S. dollars to leading European banks, having a term of three-months for a period commencing on the second Business Day immediately following such Reference Date; and provided, further, that if fewer than three banks selected by the Calculation Agent are quoting such rates, three-month LIBOR for the applicable Interest Accrual Period will be deemed to be the same as three-month LIBOR in effect for the immediately preceding Interest Accrual Period.

“License Agreement” means the Development and License Agreement, effective as of December 27, 1995, between NPS Pharmaceuticals, Inc. and Amgen, as amended, restated or supplemented from time to time.

“Licensed Technology” means the patented technology and related know-how of NPS that is the subject of the License Agreement relating to certain compounds that interact with calcium receptors on parathyroid cells, including Cinacalcet HCl, and the proceeds of and the rights to enforce each of the foregoing, as more fully described in Appendix A to this Indenture. The Licensed Technology shall also include the B&W Sublicense to the extent necessary to fully exploit the Licensed Technology.

“LLC Operating Agreement” means the limited liability company agreement of the Issuer, effective as of December 20, 2004.

“Losses” means any loss, cost, charge, expense, interest, fee, payment, demand, liability, claim, action, proceeding, penalty, fine, damages, judgment, order or other sanction other than Taxes.

“Milestone Payment” means any milestone payment payable by Amgen to NPS pursuant to Article 6 of the License Agreement.

“Moody’s” means Moody’s Investors Service, Inc. and any successor thereto or, if such corporation or its successor shall for any reason no longer perform the functions of a securities rating agency, “Moody’s” shall be deemed to refer to any other nationally recognized rating agency designated by the Issuer and meeting the definition of “nationally recognized statistical rating organization,” as set forth in the rules promulgated under the Exchange Act.

“Net Available Collections Amount” means, for any Payment Date, the excess, if any, of the Available Collections Amount for such Payment Date over the sum of (a) the Interest Amount on the Class A Notes for such Payment Date and (b) the Expenses due and payable on such Payment Date.

“Non-U.S. Person” means a person who is not a U.S. person, as defined in Regulation S.

“Noteholder” or “Holder” means any Person in whose name a Note is registered from time to time in the Register for such Notes.

“Note Purchase Agreements” means the Note Purchase Agreements, dated December 22, 2004, among the Issuer, NPS and the initial purchasers of the Class A Notes.

“Notes” means the Class A Notes, any Class B Notes and any Refinancing Notes.

“Officer’s Certificate” means a certificate signed by, with respect to the Issuer, a Manager (other than the Independent Manager) and, with respect to any other Person, any officer, director, trustee or equivalent representative.

“Operating Bank” means US Bank or any other Eligible Institution at which the Accounts are held; provided that (i) upon the resignation or removal and the replacement of the Trustee pursuant to the terms of this Indenture, the successor trustee appointed thereunder shall be the Operating Bank; and (ii) if at any time the Operating Bank ceases to be an Eligible Institution, a successor operating bank shall be appointed by the Servicer on behalf of the Trustee and all Accounts shall thereafter be transferred to and be maintained at such successor operating bank in the name of the Trustee and such successor operating bank shall thereafter be the “Operating Bank”.

“Opinion of Counsel” means a written opinion signed by legal counsel, who may be an employee of or counsel to the Issuer or NPS, that meets the requirements of Section 1.03 hereof.

“Optional Redemption” has the meaning given to such term in Section 3.09(a) hereof.

“Outstanding” means (a) with respect to the Notes of any class at any time, all Notes of such class theretofore authenticated and delivered by the Trustee except (i) any such Notes cancelled by, or delivered for cancellation to, the Trustee; (ii) any such Notes, or portions thereof, for the payment of principal of and accrued and unpaid interest on which moneys have been distributed to Noteholders by the Trustee and any such Notes, or portions thereof, for the payment or redemption of which moneys in the necessary amount have been deposited in the Redemption Account for such Notes; provided that if such Notes are to be redeemed prior to the maturity thereof in accordance with the requirements of Section 3.09 hereof, notice of such redemption shall have been given as provided in Section 3.10 hereof, or provision satisfactory to the Trustee shall have been made for giving such notice; and (iii) any such Notes in exchange or substitution for which other Notes, as the case may be, have been authenticated and delivered, or which have been paid pursuant to the terms of this Indenture (unless proof satisfactory to the Trustee is presented that any of such Notes is held by a Person in whose hands such Note is a legal, valid and binding obligation of the Issuer); and (b) when used with respect to any other evidence of indebtedness shall mean, at any time, any principal amount thereof then unpaid and outstanding (whether or not due or payable).

“Outstanding Principal Balance” means, with respect to any Note or other evidence of indebtedness Outstanding, the total principal amount of such evidence of indebtedness unpaid and outstanding at any time as determined in the case of the Notes in the information to be provided to the Servicer by the Trustee pursuant to Section 3.05(g) hereof.

“Paying Agent” has the meaning given to such term in Section 2.03 hereof and initially will be the Trustee. The term “Paying Agent” includes any additional Paying Agent.

“Payment Date” means March 30, June 30, September 30 and December 30, commencing on March 30, 2005; provided that if any such date would otherwise fall on a day which is not a Business Day, the Payment Date falling on such date shall be the first following day which is a Business Day, and provided, further, that if any such following Business Day would occur in the succeeding month, then the Payment Date shall be the first Business Day preceding such date.

“Permanent Global Note” has the meaning given to such term in Section 2.01 hereof.

“Permanent Regulation S Global Note” has the meaning given to such term in Section 2.01 hereof.

“Permitted Encumbrance” means (i) any lien for taxes, assessments and governmental charges or levies not yet due and payable or which are being contested in good faith by appropriate proceedings; and (ii) any lien created in favor of the Issuer or the Trustee.

“Permitted Holder” means (i) NPS, (ii) Amgen, (iii) the Issuer and (iv) any Person that (a) has executed a Confidentiality Agreement and (b) so long as the License Agreement has not been terminated, is not in the business of developing, manufacturing or marketing pharmaceutical or diagnostic products and is not an Affiliate of any such Person in such business.

“Person” means any natural person, firm, corporation, partnership, joint venture, association, joint-stock company, trust, unincorporated organization, government or any political subdivision thereof or any other legal entity, including public bodies.

“Pledge Agreement” means the Pledge and Security Agreement, dated as of December 22, 2004, between NPS and the Trustee, as amended, restated or supplemented from time to time.

“Pledged Equity” has the meaning given to such term in the Pledge Agreement.

“Premium” means, with respect to any Note on any Redemption Date or Payment Date, any Redemption Premium or Cash Sweep Premium, if applicable or, in the case of any Redemption Date, the portion of the Redemption Price of the Notes being redeemed in excess of the Outstanding Principal Balance of the Notes being redeemed.

“Prior Ranking Amounts” has the meaning assigned to such term in Section 3.07 hereof.

“Private Placement Legend” means the legend initially set forth on the Notes in the form set forth in Section 2.02 hereof.

“Private Placement Memorandum” means the Private Placement Memorandum of the Issuer for the Class A Notes, dated December 14, 2004.

“Purchase and Sale Agreement” means the Purchase and Sale Agreement, dated as of December 22, 2004, between NPS and the Issuer, as amended, restated or supplemented from time to time.

“Quarterly Statement Rights” means the right to receive statements under Section 7.6(A) of the License Agreement setting forth, among other things, the Royalty Payments due in respect of the calendar quarter covered by each such statement.

“Receiver” means any Person or Persons appointed as (and any additional Person or Persons appointed or substituted as) administrative receiver, receiver, manager or receiver and manager.

“Record Date” means with respect to each Payment Date, the close of business on the fifteenth (15^th) day preceding such Payment Date and, with respect to the date on which any Direction is to be given by the Noteholders, the close of business on the last Business Day prior to the solicitation of such Direction.

“Redemption” means any Optional Redemption and any redemption of Notes described in Section 3.09(c) but does not include a redemption of a Cash Sweep Principal Amount.

“Redemption Account” has the meaning given to such term in Section 3.01(a) hereof.

“Redemption Date” means the date, which shall in each case be a Payment Date, on which Notes are redeemed pursuant to a Redemption, other than a Refinancing Date.

“Redemption Premium” means, in respect of the Class A Notes, the product of the Redemption Premium Percentage and the outstanding principal balance of the Notes being redeemed and, in the case of any Refinancing Notes or Class B Notes, the amount, if any, specified in the Board Resolution or indenture supplement to be paid in the event of a Redemption of such Refinancing Notes or Class B Notes separately from the Redemption Price.

“Redemption Premium Percentage” means the following percentage, rounded to four decimal places, based on the Actual Annual Net Sales Percentage for the applicable Redemption Date:

(a) if the Actual Annual Net Sales Percentage for such Redemption Date is equal to or less than 80%, the Redemption Premium Percentage is zero;

(b) if the Actual Annual Net Sales Percentage for such Redemption Date is greater than 80% but less than 100%, the Redemption Premium Percentage is equal to the product of (i) 2.074 and (ii) the excess of such Actual Annual Net Sales Percentage over 80%; and

(c) if the Actual Annual Net Sales Percentage for such Redemption Date is equal to or greater than 100%, the Redemption Premium Percentage is 41.48%.

“Redemption Price” means, (i) in respect of the Class A Notes on any Redemption Date, an amount equal to the Outstanding Principal Balance of the Class A Notes; and (ii) in respect of any Class B Notes or any Refinancing Notes, the Redemption Price, if any, established by or pursuant to a Board Resolution or in any indenture supplemental hereto providing for the issuance of such Notes or designated as such in the form of such Notes. Any such Redemption Price may include a Premium or such Board Resolution or indenture supplement may specify a separate Redemption Premium.

“Reference Date” means, with respect to each Interest Accrual Period, the day that is two Business Days prior to the Payment Date on which such Interest Accrual Period commences; provided, however, that the Reference Date with respect to the initial Interest Accrual Period means the date that is two Business Days before the Closing Date.

“Refinancing Date” means the date, which shall in each case be a Payment Date, on which the Class A Notes or the Notes of any other class are redeemed in whole, in each case with the proceeds of Refinancing Notes as provided in Section 2.15 hereof.

“Refinancing Expenses” means all Transaction Expenses incurred in connection with an offering and issuance of Refinancing Notes.

“Refinancing Notes” means any class of Notes issued by the Issuer under this Indenture at any time and from time to time after the date hereof pursuant to Section 2.15, the proceeds of which are used to repay all of the Outstanding Principal Balance of a class of Notes and ranking pari passu with such class of Notes.

“Registrar” has the meaning given to such term in Section 2.03(a) hereof and includes any additional Registrar.

“Regulation S Global Note” has the meaning given to such term in Section 2.01(b) hereof.

“Regulation S Global Note Exchange Date” means the date of exchange of any Temporary Regulation S Global Note for any Permanent Regulation S Global Note, which date shall be forty days after the Closing Date.

“Related Documents” means the Purchase and Sale Agreement, the License Agreement, this Indenture, the Notes and the Pledge Agreement.

“Relevant Information” means any information provided to the Trustee in writing by any Service Provider retained from time to time by the Issuer pursuant to the Related Documents.

“Responsible Officer” means, (i) with respect to the Trustee, any officer within the Corporate Trust Office, including any Principal, Vice President, Managing Director, Director, Associate or any other officer of the Trustee customarily performing functions similar to those performed by any of the above designated officers and also, with respect to a particular matter, any other officer to whom such matter is referred because of such officer’s knowledge and familiarity with the particular subject and (ii) with respect to the Issuer, a Manager (other than the Independent Manager).

“Royalty Payments” means the royalties payable by Amgen pursuant to Article 7 and Section 14.3 of the License Agreement (the “Quarterly Royalty Payments”) and any amounts payable by Amgen pursuant to Section 10.1 of the License Agreement.

“Royalty Rights” means (x) the rights to (i) the Royalty Payments, (ii) any Milestone Payment, (iii) the Quarterly Statement Rights, (iv) the Audit Rights and (v) all other rights in respect of the License Agreement sold, assigned or contributed by NPS to the Issuer pursuant to the Purchase and Sale Agreement on the Closing Date and (y) any royalties and other payments in respect of the use of the Licensed Technology in the Territory that may arise outside of the License Agreement.

“Secured Obligations” has the meaning given to such term in the Granting Clause herein.

“Security Interests” means the security interests granted or expressed to be granted in the Collateral pursuant to the Granting Clause herein and in the Pledged Equity pursuant to the Pledge Agreement.

“Senior Class” means, (i) so long as any Class A Notes are Outstanding, the Class A Notes, and (ii) if no Class A Notes are Outstanding, the Class B Notes.

“Service Providers” means the Servicer, the Trustee, the Independent Manager of the Issuer, the Calculation Agent, the Operating Bank, NPS in respect of its obligations under the Intercompany Servicing Agreement and any Person that becomes the Servicer, the Trustee, the Independent Manager of the Issuer, the Calculation Agent or the Operating Bank in accordance with the terms of the applicable agreement and, subject to the written approval of Noteholders holding a majority in Outstanding Principal Balance of the Senior Class of Notes, any other Person designated as a Service Provider by the Issuer.

“Servicer” means NPS, in its capacity as collection agent under the Purchase and Sale Agreement, including its successors in interest and permitted assigns, until a successor Person shall have become the Servicer under such agreement, and thereafter “Servicer” shall mean such successor Person.

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and any successor thereto, or, if such corporation or its successor shall for any reason no longer perform the functions of a securities rating agency, “S&P” shall be deemed to refer to any other nationally recognized rating agency designated by the Issuer and meeting the definition of “nationally recognized statistical rating organization,” as set forth in the rules promulgated under the Exchange Act.

“Stated Rate of Interest” means, with respect to any class of the Notes for any Interest Accrual Period, the interest rate set forth in such class of Notes for such Interest Accrual Period.

“Stock” means all shares of capital stock, all beneficial interests in trusts, all membership interests in limited liability companies, all ordinary shares and preferred shares and any options, warrants and other rights to acquire such shares or interests.

“Subordinated Claim” has the meaning given to such term in Section 10.01 hereof.

“Subsidiary” means, as to any Person, a corporation, partnership, limited liability company or other entity of which shares of stock or other ownership interests having ordinary voting power (other than stock or such other ownership interests having such power only by reason of the happening of a contingency) to elect a majority of the board of directors or other managers of such corporation, partnership, limited liability company or other entity are at the time owned, or the management of which is otherwise controlled, directly or indirectly through one or more intermediaries, or both, by such Person.

“Tax” and “Taxes” mean any and all taxes, fees, levies, duties, tariffs, imposts, and other charges of any kind (together with any and all interest, penalties, loss, damage, liability, expense, additions to tax and additional amounts or costs incurred or imposed with respect thereto) imposed or otherwise assessed by the U.S. or by any state, local or foreign government (or any subdivision or agency thereof) or other taxing authority, including, without limitation: taxes or other charges on or with respect to income, franchises, windfall or other profits, gross receipts, property, sales, use, capital stock, payroll, employment, social security, workers’ compensation, unemployment compensation, or net worth and similar charges; taxes or other charges in the nature of excise, withholding, ad valorem, stamp, transfer, value added, taxes on goods and services, gains taxes, license, registration and documentation fees, customs duties, tariffs, and similar charges.

“Temporary Regulation S Global Note” has the meaning given to such term in Section 2.01 hereof.

“Termination Date” means the date on which the License Agreement is terminated for any reason or on which Amgen’s obligations with respect to the licenses created by the License Agreement are terminated for the U.S.

“Transaction Expenses” means the out-of-pocket expenses payable by the Issuer in connection with (i) the issuance of the Class A Notes, including placement fees, any initial fees payable to Servicer Providers and the fees and expenses of counsel in connection with the offering and issuance of the Class A Notes, as set forth in the Note Purchase Agreements and (ii) the offering and issuance of any Refinancing Notes or Class B Notes, to the extent specified in the Board Resolutions authorizing such offering and issuance.

“Trustee” has the meaning given to such term in the preamble hereof, and any successor Trustee appointed in accordance with the terms hereof.

“UCC” means the Uniform Commercial Code as in effect from time to time in the State of New York.

“US Bank” means U.S. Bank National Association, a national banking association.

“U.S. GAAP” means generally accepted accounting principles in effect in the U.S. from time to time.

“U.S. Government Obligations” means obligations of, and supported by the full faith and credit of, the U.S. government.

(a) A term has the meaning assigned to it and an accounting term not otherwise defined has the meaning assigned to it in accordance with U.S. GAAP.

(b) The terms “herein”, “hereof” and other words of similar import refer to this Indenture as a whole and not to any particular Article, Section or other subdivision.

(c) Unless otherwise indicated in context, all references to Articles, Sections, Appendices, Exhibits or Annexes refer to an Article or Section of, or an Appendix, Exhibit or Annex to, this Indenture.

(d) Words of the masculine, feminine or neuter gender shall mean and include the correlative words of other genders, and words in the singular shall include the plural, and vice versa.

(e) The terms “include”, “including” and similar terms shall be construed as if followed by the phrase “without limitation”.

(f) Unless otherwise indicated, references to a class of Notes shall be to the Class A Notes and Class B Notes or to a class of Refinancing Notes, as applicable.

(g) References in this Indenture to an agreement or other document (including this Indenture) include references to such agreement or document as amended, replaced or otherwise modified in accordance with the provisions of this Indenture, and the provisions of this Indenture apply to successive events and transactions.

(h) References in this Indenture to any statute or other legislative provision shall include any statutory or legislative modification or re-enactment thereof, or any substitution therefor.

(i) References in this Indenture to the Notes include the terms and conditions in this Indenture applicable to the Notes; and any reference to any amount of money due or payable by reference to the Notes shall include any sum covenanted to be paid by the Issuer under this Indenture in respect of the Notes.

(j) References in this Indenture to any action, remedy or method of judicial proceeding for the enforcement of the rights of creditors or of security shall be deemed to include, in respect of any jurisdiction other than the State of New York, references to such action, remedy or method of judicial proceeding for the enforcement of the rights of creditors or of security available or appropriate in such jurisdiction as shall most nearly approximate such action, remedy or method of judicial proceeding described or referred to in this Indenture.

(k) Where any payment is to be made, funds applied or any calculation is to be made hereunder on a day which is not a Business Day, unless any Related Document otherwise provides, such payment shall be made, funds applied and calculation made on the next succeeding Business Day, and payments shall be adjusted accordingly, including interest unless otherwise specified.

Section 1.03 Compliance Certificates and Opinions. Upon any application or request by the Issuer to the Trustee to take any action under any provision of this Indenture, the Issuer shall furnish to the Trustee an Officer’s Certificate stating that, in the opinion of the signers thereof in their capacity as such, all conditions precedent, if any, provided for in this Indenture relating to the proposed action have been complied with, and an Opinion of Counsel stating that, in the opinion of such counsel, all such conditions precedent, if any, have been complied with, except that in the case of any such application or request as to which the furnishing of such documents is specifically required by any provision of this Indenture relating to such particular application or request, no additional certificate or opinion need be furnished.

Every certificate or opinion with respect to compliance with a condition or covenant provided for in this Indenture (other than a certificate provided pursuant to Section 5.03 hereof) or any indenture supplemental hereto shall include:

(1) a statement that each individual signing such certificate or opinion has read such covenant or condition and the definitions in this Indenture relating thereto;

(2) a brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based;

(3) a statement that, in the opinion of each such individual in its capacity as such, he has made such examination or investigation as is necessary to enable him to express an informed opinion as to whether or not such covenant or condition has been complied with; and

(4) a statement as to whether, in the opinion of each such individual, such condition or covenant has been complied with.

Section 1.04 Acts of Noteholders. (a) Any direction, consent, waiver or other action provided by this Indenture in respect of the Notes of any class to be given or taken by Noteholders may be embodied in and evidenced by one or more instruments of substantially similar tenor signed by such Noteholders in person or by an agent or proxy duly appointed in writing; and, except as herein otherwise expressly provided, such action shall become effective when such instrument or instruments are delivered to the Trustee or to the Issuer. Such instrument or instruments (and the action embodied therein and evidenced thereby) are herein sometimes referred to as the “Act” of the Noteholders signing such instrument or instruments. Proof of execution of any such instrument or of a writing appointing any such agent shall be sufficient for any purpose under this Indenture and conclusive in favor of the Trustee or the Issuer, if made in the manner provided in this Section.

(b) The fact and date of the execution by any Person of any such instrument or writing may be proved by the certificate of any notary public or other officer of any jurisdiction authorized to take acknowledgments of deeds or administer oaths that the Person executing such instrument acknowledged to him the execution thereof, or by an affidavit of a witness to such execution sworn to before any such notary or such other officer and where such execution is by an officer of a corporation or association, trustee of a trust or member of a

partnership, on behalf of such corporation, association, trust or partnership, such certificate or affidavit shall also constitute sufficient proof of his authority. The fact and date of the execution of any such instrument or writing, or the authority of the Person executing the same, may also be proved in any other reasonable manner which the Trustee deems sufficient.

(c) In determining whether the Holders of Notes have given any direction, consent, request, demand, authorization, notice, waiver or other Act (a “Direction”), under this Indenture, Notes owned by the Issuer, NPS or any Affiliate of any such Person shall be disregarded and deemed not to be Outstanding for purposes of any such determination. In determining whether the Trustee shall be protected in relying upon any such Direction, only Notes which a Responsible Officer of the Trustee actually knows to be so owned shall be so disregarded. Notwithstanding the foregoing, (i) if any such Person owns 100% of the Notes of any class Outstanding, such Notes shall not be so disregarded as aforesaid, and (ii) if any amount of Notes of such class so owned by any such Person have been pledged in good faith, such Notes shall not be disregarded as aforesaid if the pledgee establishes to the satisfaction of the Trustee the pledgee’s right so to act with respect to such Notes and that the pledgee is not the Issuer, NPS or any Affiliate of any such Person.

(d) The Issuer may at its option, by delivery of Officer’s Certificate(s) to the Trustee, set a record date other than the Record Date to determine the Noteholders in respect of the Notes of any class entitled to give any Direction in respect of such Notes. Notwithstanding Section 316(c) of the Trust Indenture Act, such record date shall be the record date specified in such Officer’s Certificate which shall be a date not more than 30 days prior to the first solicitation of Noteholders in connection therewith. If such a record date is fixed, such Direction may be given before or after such record date, but only the Noteholders of record of the applicable class at the close of business on such record date shall be deemed to be Noteholders for the purposes of determining whether Noteholders of the requisite proportion of Outstanding Notes of such class have authorized or agreed or consented to such Direction, and for that purpose the Outstanding Notes of such class shall be computed as of such record date; provided that no such Direction by the Noteholders on such record date shall be deemed effective unless it shall become effective pursuant to the provisions of this Indenture not later than one year after the record date.

(e) Any Direction or other action by the Holder of any Note shall bind the Holder of every Note issued upon the transfer thereof or in exchange therefor or in lieu thereof, whether or not notation of such action is made upon such Note.

Section 2.01 Amount Not to Exceed the Initial Outstanding Principal Balance; Terms; Form; Execution and Delivery. (a) The Outstanding Principal Balance of any class of Notes which may be authenticated and delivered from time to time under this Indenture shall not exceed, with respect to the Class A Notes, the initial Outstanding Principal Balance for the Class A Notes set forth in the definition thereof or, with respect to any Class B Notes or any class of Refinancing Notes, the initial Outstanding Principal Balance authorized in the Board Resolutions establishing such Class B Notes or Refinancing Notes; provided that the Outstanding Principal Balance of any such class of Refinancing Notes shall not be less than the Redemption Price of the class of Notes being refinanced in whole thereby and any Redemption Premium, plus Transaction Expenses relating thereto and the amount of any Interest Reserve Account established in respect of such Refinancing Notes, and that any Refinancing Notes shall be issued in accordance with Section 2.15 hereof.

(b) There shall be issued, authenticated and delivered on the Closing Date and on the date of issuance of any Refinancing Notes or Class B Notes to each of the Noteholders Notes in the principal amounts and maturities and bearing the interest rates, in each case in registered form and, in the case of the Class A Notes, substantially in the form set forth in Exhibit A to this Indenture or, in the case of any Class B Notes or Refinancing Notes, substantially in the form set forth in any indenture supplemental hereto with such appropriate insertions, omissions, substitutions and other variations as are required or permitted by this Indenture, and may have such letters, numbers or other marks of identification and such legends or endorsements typewritten, printed, lithographed or engraved thereon, as may, consistently herewith, be prescribed by the Trustee. The Trustee shall authenticate and make Notes available for delivery only upon the written order of the Issuer signed by an officer of the Issuer. Such order shall specify the aggregate principal amount of Notes to be authenticated, the date of issue, whether they are to be issued as Global Notes or Definitive Notes and delivery instructions.

Definitive Notes of each class shall be typewritten, printed, lithographed or engraved or produced by any combination of these methods, as determined by the Trustee.

The Class A Notes and any Notes offered and sold in reliance on Rule 144A shall be issued initially in the form of one or more permanent global Notes in registered form, substantially in the form set forth in the applicable exhibit to this Indenture or in any indenture supplemental hereto (each, a “Permanent Global Note”), registered in the name of the nominee of DTC, deposited with the Trustee, as custodian for DTC, duly executed by the Issuer and authenticated by the Trustee as hereinafter provided. The aggregate principal amount of each Permanent Global Note may from time to time be increased or decreased by adjustments made on the records of the Trustee, as custodian for DTC or its nominee, in accordance with the instructions given by the Holder thereof, as hereinafter provided.

Any Notes offered and sold in offshore transactions in reliance on Regulation S shall be issued initially in the form of one or more temporary global Notes in registered form substantially in the form set forth in the applicable exhibit to this Indenture or in any indenture supplemental hereto (each, a “Temporary Regulation S Global Note”), registered in the name of the nominee of DTC, deposited with the Trustee, as custodian for the DTC, duly executed by the Issuer and authenticated by the Trustee as hereinafter provided. At any time following the applicable Regulation S Global Note Exchange Date, upon receipt by the Trustee and the Issuer of a certificate substantially in the form of Exhibit I hereto, executed by Euroclear or Clearstream, as the case may be, together with copies of certificates from Euroclear and Clearstream certifying that they have received certification of non-U.S. beneficial ownership of a Temporary Regulation S Global Note (or portion thereof) with respect to any Notes to be exchanged, one or more permanent Global Notes for such Notes in registered form substantially in the form set forth in the applicable exhibit to this Indenture or in any indenture supplemental hereto (each, a “Permanent Regulation S Global Note”; and together with each Temporary Regulation S Global Note, the “Regulation S Global Notes”) duly executed by the Issuer and authenticated by the Trustee as hereinafter provided shall be deposited with the Trustee, as custodian for the DTC, and the Registrar shall reflect on its books and records the date and a decrease in the principal amount of the Temporary Regulation S Global Note of such class in an amount equal to the principal amount of the beneficial interest in such Temporary Regulation S Global Note exchanged. Until the Regulation S Global Note Exchange Date with respect to any Temporary Regulation S Global Note, interests in such Temporary Regulation S Global Note may be held only through Agent Members acting for and on behalf of Euroclear and Clearstream.

Notes, if so provided herein or in any indenture supplemental hereto, shall be issued in the form of permanent certificated Notes in registered form in substantially the form set forth in the applicable exhibit to this Indenture (collectively with the definitive, fully registered Notes issued pursuant to Section 2.10(b) hereof, the “Definitive Notes”).

Interest shall accrue on any class of Floating Rate Notes from the relevant Closing Date and shall be computed for each Interest Accrual Period on the basis of a 360-day year and the actual number of days elapsed in such Interest Accrual Period on the Outstanding Principal Balance of such Notes. Interest shall accrue on the Class A Notes and on any other class of Fixed Rate Notes from the relevant Closing Date and shall be computed for each Interest Accrual Period on the basis of a 360-day year consisting of twelve 30-day months.

If a B&W Payment is made by the Trustee pursuant to Section 3.08 hereof or if an Amgen Payment is made, the Stated Interest Rate on the Class A Notes shall be increased by 0.75% per annum during the period beginning on the first day any such B&W Payment or Amgen Payment is outstanding and ending on the date on which NPS has reimbursed the entire amount of such B&W Payment or Amgen Payment and any other B&W Payments made pursuant to Section 3.08 or Amgen Payments made together with the entire amount of the increase in the Stated Interest Rate on the Class A Notes imposed by this sentence. An Amgen Payment shall be outstanding from the date on which the Servicer or the Issuer shall notify the Trustee in writing that such Amgen Payment is first outstanding and shall be in the amount specified by the Servicer or the Issuer in such notification, and if both the Servicer and the Issuer notify the Trustee of different dates and/or different amounts, the date and amount specified by the Issuer shall be conclusively presumed to be correct in the absence of willful misconduct or fraud.

(c) On the date of any Refinancing, the Issuer shall issue and deliver as provided in Section 2.15 hereof an aggregate principal amount of Refinancing Notes having the maturities and bearing the interest rates and such other terms authorized by one or more Board Resolutions or in any indenture supplemental hereto providing for the issuance of such Notes or specified in the form of such Notes, in each case in accordance with such Section 2.15.

(d) On the date of the issuance, if any, of any Class B Notes, the Issuer shall issue and deliver, as provided in Section 2.16 hereof, an aggregate principal amount of Class B Notes having the maturities and bearing the interest rates and such other terms authorized by one or more Board Resolutions or in any indenture supplemental hereto providing for the issuance of such Notes or specified in the form of such Notes, in each case in accordance with such Section 2.16.

(e) The Notes shall be executed on behalf of the Issuer by the manual or facsimile signature of a Manager of the Issuer other than the Independent Manager.

(f) Each Note bearing the manual or facsimile signatures of any individual who was at the time such Note was executed a Manager of the Issuer other than the Independent Manager shall bind the Issuer, notwithstanding that any such individual has ceased to hold such office prior to the authentication and delivery of such Notes or any payment thereon.

(g) At any time and from time to time after the execution of any Notes, the Issuer may deliver such Notes to the Trustee for authentication and, subject to the provisions of clause (h) below, the Trustee shall authenticate such Notes by manual or facsimile signature upon receipt by it of written orders of the Issuer. The Notes shall be authenticated on behalf of the Trustee by any Responsible Officer of the Trustee.

(h) No Note shall be entitled to any benefit under this Indenture or be valid or obligatory for any purpose, unless it shall have been executed on behalf of the Issuer as provided in clause (e) above and authenticated by or on behalf of the Trustee as provided in clause (g) above. Such signatures shall be conclusive evidence that such Note has been duly executed and authenticated under this Indenture. Each Note shall be dated the date of its authentication.

Section 2.02 Restrictive Legends. Each Permanent Global Note, each Regulation S Global Note and each Definitive Note issued in reliance on Section 4(2) of the Securities Act (and all Notes issued in exchange therefor or upon registration of transfer or substitution thereof) shall bear the following legend on the face thereof:

THIS NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), THE SECURITIES LAWS OF ANY STATE OR THE SECURITIES LAWS OF ANY OTHER JURISDICTION, NOR IS SUCH REGISTRATION CONTEMPLATED. NEITHER THIS NOTE NOR ANY INTEREST HEREIN MAY BE ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED, SOLD OR OFFERED FOR SALE OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION UNDER THE SECURITIES ACT OR AN EXEMPTION FROM SUCH REGISTRATION THEREUNDER AND ANY OTHER APPLICABLE SECURITIES LAW REGISTRATION REQUIREMENTS. EACH PERSON WHO ACQUIRES OR ACCEPTS THIS NOTE OR AN INTEREST HEREIN BY SUCH ACQUISITION OR ACCEPTANCE (1) REPRESENTS THAT (A) IT IS A “QUALIFIED INSTITUTIONAL BUYER” (AS DEFINED IN RULE 144A UNDER THE SECURITIES ACT), (B) IT IS AN INSTITUTIONAL ACCREDITED INVESTOR WITHIN THE MEANING OF SUBPARAGRAPH (a) (1), (2), (3) OR (7) OF RULE 501 UNDER THE SECURITIES ACT (AN “INSTITUTIONAL ACCREDITED INVESTOR”) OR (C) IT IS NOT A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION IN COMPLIANCE WITH RULE 904 OF REGULATION S UNDER THE SECURITIES ACT, (2) AGREES THAT IT WILL NOT PRIOR TO (X) THE DATE WHICH IS TWO YEARS (OR SUCH SHORTER PERIOD OF TIME AS PERMITTED BY RULE 144(k) UNDER THE SECURITIES ACT OR ANY SUCCESSOR PROVISION THEREUNDER) AFTER THE LATER OF THE ORIGINAL ISSUE DATE HEREOF (OR ANY PREDECESSOR OF THIS NOTE) AND (Y) SUCH LATER DATE, IF ANY, AS MAY BE REQUIRED BY APPLICABLE LAWS (THE “RESALE RESTRICTION TERMINATION DATE”) OFFER, SELL OR OTHERWISE TRANSFER THIS NOTE OR AN INTEREST HEREIN, EXCEPT (A) TO THE ISSUER OR A SUBSIDIARY THEREOF, (B) FOR SO LONG AS THIS NOTE IS ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE SECURITIES ACT, TO A PERSON IT REASONABLY BELIEVES IS A QUALIFIED INSTITUTIONAL BUYER THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A UNDER THE SECURITIES ACT, (C) TO AN INSTITUTIONAL ACCREDITED INVESTOR THAT IS PURCHASING THIS NOTE OR AN

INTEREST HEREIN, AS THE CASE MAY BE, FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF SUCH AN INSTITUTIONAL ACCREDITED INVESTOR FOR INVESTMENT PURPOSES AND NOT WITH A VIEW TO, OR FOR OFFER OR SALE IN CONNECTION WITH, ANY DISTRIBUTION IN VIOLATION OF THE SECURITIES ACT, (D) OUTSIDE THE UNITED STATES IN AN OFFSHORE TRANSACTION IN COMPLIANCE WITH RULE 904 OF REGULATION S UNDER THE SECURITIES ACT (IF AVAILABLE) OR (E) PURSUANT TO ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND (3) AGREES THAT IT WILL GIVE TO EACH PERSON TO WHOM THIS NOTE OR AN INTEREST HEREIN IS TRANSFERRED A NOTICE SUBSTANTIALLY TO THE EFFECT OF THIS LEGEND; PROVIDED THAT THE ISSUER AND THE TRUSTEE SHALL HAVE THE RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSE (2)(C), (D) OR (E) OF THIS PARAGRAPH, TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. THIS LEGEND WILL BE REMOVED UPON THE REQUEST OF THE HOLDER AFTER THE RESALE RESTRICTION TERMINATION DATE. AS USED HEREIN, THE TERMS “OFFSHORE TRANSACTION” “UNITED STATES” AND “U.S. PERSON” HAVE THE MEANING GIVEN TO THEM BY REGULATION S UNDER THE SECURITIES ACT.

BY ITS PURCHASE AND ACCEPTANCE OF A NOTE, EACH PURCHASER WILL BE DEEMED TO HAVE REPRESENTED AND WARRANTED THAT EITHER (I) NO PLAN ASSETS HAVE BEEN USED TO PURCHASE SUCH NOTES, OR (II) (X) ONE OR MORE PROHIBITED TRANSACTION STATUTORY OR ADMINISTRATIVE EXEMPTIONS APPLIES SUCH THAT THE USE OF SUCH PLAN ASSETS TO PURCHASE AND HOLD SUCH NOTES WILL NOT CONSTITUTE A NON-EXEMPT PROHIBITED TRANSACTION; (Y) THE PLAN FIDUCIARY AUTHORIZING THE INVESTMENT IN THE NOTES HAS DETERMINED THAT SUCH INVESTMENT IS PRUDENT AND OTHERWISE CONSISTENT WITH THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974, AS AMENDED (“ERISA”), OR OTHER APPLICABLE LAW; AND (Z) THE INDIVIDUAL EXECUTING THE NOTE PURCHASE AGREEMENT IS DULY AUTHORIZED UNDER THE APPLICABLE PLAN DOCUMENTS AND/OR APPLICABLE LAW TO SO BIND THE PLAN. “PLAN” IS DEFINED TO INCLUDE CERTAIN GOVERNMENTAL PLANS, CERTAIN CHURCH PLANS, EMPLOYEE BENEFIT PLANS AND CERTAIN OTHER RETIREMENT PLANS AND ARRANGEMENTS, INCLUDING INDIVIDUAL RETIREMENT ACCOUNTS AND ANNUITIES, THAT ARE SUBJECT TO ERISA AND/OR THE INTERNAL REVENUE CODE OF 1986, AS AMENDED AND ANY ENTITY THAT MAY BE DEEMED TO HOLD THE ASSETS OF ANY SUCH PLANS.

THE NOTES MAY NOT BE RESOLD OR TRANSFERRED EXCEPT AS DESCRIBED IN THE FOREGOING, AND ANY PROPOSED TRANSFEREE SHALL EXECUTE A CONFIDENTIALITY AGREEMENT IN THE FORM ATTACHED AS EXHIBIT N TO THE INDENTURE.

THE NOTES MAY NOT BE SOLD OR TRANSFERRED TO ANY PERSON THAT IS ENGAGED IN THE BUSINESS OF DEVELOPING, MANUFACTURING OR MARKETING PHARMACEUTICAL OR DIAGNOSTIC PRODUCTS OR TO AN AFFILIATE (AS DEFINED IN THE INDENTURE REFERRED TO HEREINAFTER) OF ANY SUCH PERSON ENGAGED IN ANY SUCH BUSINESS.

UNLESS THIS NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY NOTE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

TRANSFERS OF THIS GLOBAL NOTE SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES OF CEDE & CO. OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL NOTE SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH IN SECTION 2.11 OF THE INDENTURE.

Each Global Note for the Class A Notes shall also bear the following legend on the face thereof:

THIS NOTE IS ISSUED WITH ORIGINAL ISSUE DISCOUNT UNDER SECTIONS 1272, 1273, AND 1275 OF THE INTERNAL REVENUE CODE OF 1986, AS AMENDED, AND IS SUBJECT TO THE RULES FOR DEBT INSTRUMENTS WITH CONTINGENT PAYMENTS UNDER TREASURY REGULATION § 1.1275-4(b). FOR INFORMATION REGARDING THE ISSUE PRICE, THE AMOUNT OF ORIGINAL ISSUE DISCOUNT, THE ISSUE DATE, THE YIELD TO MATURITY, THE COMPARABLE YIELD AND PROJECTED PAYMENT SCHEDULE FOR THIS NOTE, YOU SHOULD SUBMIT A WRITTEN REQUEST TO THE ISSUER AT THE FOLLOWING ADDRESS: CINACALCET ROYALTY SUB LLC, 420 CHIPETA WAY, SALT LAKE CITY, UTAH 84108-1256, ATTENTION: ASSISTANT TREASURER

Each Temporary Regulation S Global Note shall bear the following legend on the face thereof:

THIS NOTE IS A TEMPORARY REGULATION S GLOBAL NOTE WITHIN THE MEANING OF THE INDENTURE REFERRED TO HEREINAFTER AND IS SUBJECT TO RESTRICTIONS ON THE TRANSFER AND EXCHANGE THEREOF AND ON THE PAYMENT OF INTEREST THEREON AS SPECIFIED IN THE INDENTURE.

Section 2.03 Registrar and Paying Agent. (a) With respect to each class of Notes, there shall at all times be maintained an office or agency in the location set forth in Section 12.05 hereof where the Notes of such class may be presented or surrendered for registration of transfer or for exchange (each, a “Registrar”), and for payment thereof (each, a “Paying Agent”) and where notices and demands to or upon the Issuer in respect of such Notes may be served. The Trustee shall be the initial Paying Agent, and the Issuer shall not be permitted to act as a Paying Agent. The Issuer shall cause each Registrar to keep a register of such class of Notes for which it is acting as Registrar and of their transfer and exchange (the “Register”). Written notice of the location of each such other office or agency and of any change of location thereof shall be given by the Trustee to the Issuer and the Holders of such class of Notes. In the event that no such office or agency shall be maintained or no such notice of location or of change of location shall be given, presentations and demands may be made and notices may be served at the Corporate Trust Office of the Trustee.

(b) Each Authorized Agent in the location set forth in Section 12.05 shall be a bank or trust company, shall be a corporation organized and doing business under the laws of the U.S. or any state or territory thereof or of the District of Columbia, with a combined capital and surplus of at least $75,000,000 (or having a combined capital and surplus in excess of $5,000,000 and the obligations of which, whether now in existence or hereafter incurred, are fully and unconditionally guaranteed by a corporation organized and doing business under the laws of the U.S., any state or territory thereof or of the District of Columbia and having a combined capital and surplus of at least $75,000,000) and shall be authorized under the laws of the U.S. or any state or territory thereof to exercise corporate trust powers, subject to supervision by Federal or state authorities (such requirements, the “Eligibility Requirements”). The Trustee shall initially be a Paying Agent and Registrar hereunder with respect to the Notes. Each Registrar other than the Trustee shall furnish to the Trustee, at least five (5) Business Days prior to each Payment Date, and at such other times as the Trustee may request in writing, a copy of the Register maintained by such Registrar.

(c) Any corporation into which any Authorized Agent may be merged or converted or with which it may be consolidated, or any corporation resulting from any merger, consolidation or conversion to which any Authorized Agent shall be a party, or any corporation succeeding to the corporate trust business of any Authorized Agent, shall be the successor of such Authorized Agent hereunder, if such successor corporation is otherwise eligible under this Section, without the execution or filing of any paper or any further act on the part of the parties hereto or such Authorized Agent or such successor corporation.

(d) Any Authorized Agent may at any time resign by giving written notice of resignation to the Trustee and the Issuer. The Issuer may, and at the request of the Trustee shall, at any time terminate the agency of any Authorized Agent by giving written notice of termination to such Authorized Agent and to the Trustee. Upon the resignation or termination of an Authorized Agent or if at any time any such Authorized Agent shall cease to be eligible under this Section (when, in either case, no other Authorized Agent performing the functions of such Authorized Agent shall have been appointed by the Trustee), the Issuer shall promptly appoint one or more qualified successor Authorized Agents, reasonably satisfactory to the Trustee, to perform the functions of the Authorized Agent which has resigned or whose agency has been terminated or who shall have ceased to be eligible under this Section. The Issuer shall give written notice of any such appointment made by it to the Trustee; and in each case the Trustee shall mail notice of such appointment to all Holders of the related class of Notes as their names and addresses appear on the Register for such class of Notes.

(e) The Issuer agrees to pay, or cause to be paid, from time to time to each Authorized Agent reasonable compensation for its services and to reimburse it for its reasonable expenses to be agreed to pursuant to separate agreements with each such Authorized Agent.

Section 2.04 Paying Agent to Hold Money in Trust. The Trustee shall require each Paying Agent other than the Trustee to agree in writing that all moneys deposited with any Paying Agent for the purpose of any payment on the Notes shall be deposited and held in trust for the benefit of the Holders entitled to such payment, subject to the provisions of this Section. Moneys so deposited and held in trust shall constitute a separate trust fund for the benefit of the Holders with respect to which such money was deposited.

The Trustee may at any time, for the purpose of obtaining the satisfaction and discharge of this Indenture or for any other purpose, direct any Paying Agent to pay to the Trustee all sums held in trust by such Paying Agent; and, upon such payment by any Paying Agent to the Trustee, such Paying Agent shall be released from all further liability with respect to such money.

Section 2.05 Method of Payment. (a) On each Payment Date, the Trustee shall, or shall instruct a Paying Agent to, pay, to the extent of the Available Collections Amount for such Payment Date, to the Noteholders all interest, principal and Premium, if any, on each class of Notes in the amounts determined by the Trustee pursuant to Section 3.05; provided, that payment on a Temporary Regulation S Global Note shall be made to the Holder thereof only in conformity with Section 2.05(c) hereof and payment on any Note may be deferred as provided in Section 2.05(d) hereof. Each payment on any Payment Date other than the Final Payment Date with respect to any class of Notes shall be made by the Trustee or Paying Agent to the Noteholders as of the Record Date for such Payment Date. The final payment with respect to any Note, however, shall be made only upon presentation and surrender of such Note by the Noteholder or its agent at the Corporate Trust Office or agency of the Trustee or Paying Agent specified in the notice given by the Trustee or Paying Agent with respect to such final payment.

(b) At such time, if any, as the Notes of any class are issued in the form of Definitive Notes, payments on a Payment Date shall be made by check mailed to each Noteholder of a Definitive Note on the applicable Record Date at its address appearing on the Register maintained with respect to such class of Notes. Alternatively, upon application in writing to the Trustee, not later than the applicable Record Date, by a Noteholder, any such payments shall be made by wire transfer to an account designated by such Noteholder at a financial institution in New York, New York; provided that the final payment for each class of Notes shall be made only upon presentation and surrender of the Definitive Notes of such class by the Noteholder or its agent at the Corporate Trust Office or agency of the Trustee or Paying Agent specified in the notice of such final payment given by the Trustee or Paying Agent. The Trustee or Paying Agent shall mail such notice of the final payment of such class of Notes to each Noteholder of such class, specifying the date and amount of such final payment.

(c) The beneficial owner of a Temporary Regulation S Global Note may arrange to receive interest installments through Euroclear or Clearstream on such Temporary Regulation S Global Note only after delivery by such beneficial owner to Euroclear or Clearstream, as the case may be, of a written certification substantially in the form of Exhibit M-1 hereto, and upon delivery of Euroclear or Clearstream, as the case may be, to the Paying Agent of a certification or certifications substantially in the form of Exhibit M-2 hereto. No interest shall be paid to any beneficial owner and no interest shall be paid to Euroclear or Clearstream on such beneficial owner’s interest in a Temporary Regulation S Global Note unless Euroclear or Clearstream, as the case may be, has provided such a certification to the Paying Agent with respect to such interest.

(d) If the Issuer informs the Trustee that any Holder or any beneficial owner of an interest in any Global Note has not executed and delivered to the Issuer a Confidentiality Agreement, the Trustee shall withhold and deposit in the Escrow Account the portion of any payment of principal, Premium or interest on the Notes allocable to the Notes held by such Holder or the undivided interest in such Global Note allocable to such beneficial owner. The Trustee shall distribute the amounts so withheld, without interest, to such Holder or beneficial owner upon receipt by the Trustee of written notice from the Issuer that such Holder or beneficial owner has executed and delivered a Confidentiality Agreement.

Section 2.06 Minimum Denomination. Each class of Notes shall be issued in minimum denominations of $250,000 and integral multiples of $1,000 in excess thereof.

Section 2.07 Transfer and Exchange; Cancellation. The Notes are issuable only in registered form. A Holder may transfer a Note only by written application to the Registrar stating the name of the proposed transferee and otherwise complying with the terms of this Indenture, including the requirement for delivery of a Confidentiality Agreement as set forth in Section 2.11. No such transfer shall be effected until, and such transferee shall succeed to the rights of a Holder only upon, final acceptance and registration of the transfer by the Registrar in the Register and confirmation by the Issuer that such Holder has delivered a Confidentiality Agreement to the Issuer and that such Holder is a Permitted Holder.

Prior to the due presentment for registration of transfer of a Note and satisfaction of the requirements specified in the last sentence of the preceding paragraph, the Issuer and the Trustee may deem and treat the applicable registered Noteholder as the absolute owner and Holder of such Note for the purpose of receiving payment of all amounts payable with respect to such Note and for all other purposes and shall not be affected by any notice to the contrary. The Registrar (if different from the Trustee) shall promptly notify the Trustee and the Trustee shall promptly notify the Issuer of each request for a registration of transfer of a Note by furnishing the Issuer a copy of such request.

Furthermore, any Holder of a Global Note shall, by acceptance of such Global Note, agree that, subject to Section 2.10(b) hereof, transfers of beneficial interests in such Global Note may be effected only through a book-entry system maintained by the Holder of such Global Note (or its agent) and that ownership of a beneficial interest in such Note shall be required to be reflected in a book-entry. When Notes are presented to the Registrar with a request to register the transfer or to exchange them for an equal principal amount of Notes of other authorized denominations, the Registrar shall register the transfer or make the exchange as requested if its requirements for such transactions are met (including, in the case of a transfer, that such Notes are duly endorsed or accompanied by a written instrument of transfer in form satisfactory to the Trustee and Registrar duly executed by the Holder thereof or by an attorney who is authorized in writing to act on behalf of the Holder). To permit registrations of transfers and exchanges, the Issuer shall execute and the Trustee shall authenticate Notes at the Registrar’s request. Except as set forth in Sections 2.08 and 2.09 hereof, no service charge shall be made for any registration of transfer or exchange or redemption of the Notes.

The Issuer shall not be required to exchange or register the transfer of any Notes as above provided during the 15-day period preceding the Final Maturity Date of any such Notes or during a 15-day period preceding the first mailing of any notice of Redemption or Refinancing of Notes to be redeemed or refinanced. The Issuer shall not be required to exchange or register the transfer of any Notes that have been selected, called or are being called for Redemption or Refinancing except, in the case of any Notes where notice has been given that such Notes are to be redeemed in part, the portion thereof not so to be redeemed.

The Issuer at any time may deliver Notes to the Trustee for cancellation. The Trustee and no one else shall cancel and destroy in accordance with its customary practices in effect from time to time (subject to the record retention requirements of the Exchange Act) any such Notes, together with any other Notes surrendered to it for registration of transfer, exchange or payment. The Issuer may not issue new Notes (other than Refinancing Notes issued in connection with any Refinancing) to replace Notes it has redeemed, paid or delivered to the Trustee for cancellation.

Section 2.08 Mutilated, Destroyed, Lost or Stolen Notes. If any Note shall become mutilated, destroyed, lost or stolen, the Issuer shall, upon the written request of the Holder thereof and presentation of the Note

or satisfactory evidence of destruction, loss or theft thereof to the Trustee or Registrar and a confirmation by the Issuer to the Trustee that such Holder has delivered a Confidentiality Agreement to the Issuer, issue, and the Trustee shall authenticate and the Trustee or Registrar shall deliver in exchange therefor or in replacement thereof, a new Note, payable to such Holder in the same principal amount, of the same maturity, with the same payment schedule, bearing the same interest rate and dated the date of its authentication. If the Note being replaced has become mutilated, such Note shall be surrendered to the Trustee or a Registrar and forwarded to the Issuer by the Trustee or such Registrar. If the Note being replaced has been destroyed, lost or stolen, the Holder thereof shall furnish to the Issuer, the Trustee or a Registrar (i) such security or indemnity as may be required by them to save the Issuer, the Trustee and such Registrar harmless (an unsecured indemnity from any QIB being acceptable security) and (ii) evidence satisfactory to the Issuer, the Trustee and such Registrar of the destruction, loss or theft of such Note and of the ownership thereof (an affidavit from any QIB being satisfactory evidence). The Noteholders will be required to pay any tax or other governmental charge imposed in connection with such exchange or replacement and any other expenses (including the fees and expenses of the Trustee and any Registrar) connected therewith.

Section 2.09 Payments of Transfer Taxes. Upon the transfer of any Note or Notes pursuant to Section 2.07 hereof, the Issuer or the Trustee may require from the party requesting such new Note or Notes payment of a sum to reimburse the Issuer or the Trustee for, or to provide funds for the payment of, any transfer tax or similar governmental charge payable in connection therewith.

Section 2.10 Book-Entry Provisions. (a) Global Notes shall (i) be registered in the name of DTC for such Notes or in the name of the nominee of DTC, (ii) be delivered to the Trustee as custodian for DTC and (iii) bear the Private Placement Legend as set forth in Section 2.02 hereof.

Members of, or participants in, DTC (“Agent Members”) shall have no rights under this Indenture with respect to any Global Note held on their behalf by DTC, or the Trustee as its custodian, or under such Global Note, and DTC may be treated by the Issuer, the Trustee and any agent of the Issuer or the Trustee as the absolute owner of such Global Note for all purposes whatsoever.

Whenever notice or other communication to the Noteholders of any class of Global Notes is required under this Indenture, unless and until Definitive Notes shall have been issued pursuant to Section 2.10(b) below, the Trustee shall give all such notices and communications specified herein to be given to Noteholders of such class of Global Notes to DTC and/or the Agent Members, and shall make available additional copies as requested by such Agent Members, subject to the limitations on distribution contained in Section 2.11.

Notwithstanding the foregoing, nothing herein shall prevent the Issuer, the Trustee or any agent of the Issuer or the Trustee from giving effect to any written certification, proxy or other authorization furnished by DTC or impair, as between DTC and its Agent Members, the operation of customary practices governing the exercise of the rights of a Holder of any Global Note. Neither the Issuer nor the Trustee shall be liable for any delay by DTC in identifying the Agent Members in respect of the Global Notes, and the Issuer and the Trustee may conclusively rely on, and shall be fully protected in relying on, instructions from DTC for all purposes (including with respect to the registration and delivery, and the respective principal amounts, of any Global Notes to be issued).

(b) Transfers of a Global Note shall be limited to transfers of such Global Note in whole, but not in part, to DTC, its successors or their respective nominees. Interests of Agent Members in a Global Note may be transferred in accordance with the rules and procedures of DTC and the provisions of Section 2.11 hereof. Definitive Notes shall be issued to the individual Agent Members or Beneficial Holders or their nominees in exchange for their Beneficial Interests in the Permanent Global Note or the Regulation S Global Note, respectively, with respect to any class of Notes only if (i) the Issuer advises the Trustee in writing that DTC is no longer willing or able to properly discharge its responsibilities as depositary with respect to the Notes and the Trustee or the Issuer is unable to appoint a qualified successor within 90 days of such notice, (ii) the Issuer, at its option, elects to terminate the book-entry system through DTC or (iii) during the occurrence of an Event of Default with respect to any class of Notes, Noteholders of such class representing an aggregate of not less than 51% of the aggregate Outstanding Principal Balance of such class of Notes advise the Issuer, the Trustee and DTC through the Agent Members in writing that the continuation of a book-entry system through DTC (or a successor thereto) is no longer in the best interests of the Noteholders of such class. Upon the occurrence of any event described in the immediately preceding sentence, the Trustee shall notify all affected Noteholders of such class, through DTC, of the occurrence of such event and of the availability of Definitive Notes of such class; provided, however, that in no event shall the Temporary Regulation S Global Note be exchanged for Definitive Notes prior to the later of (x) the Regulation S Global Note Exchange Date and (y) the date of receipt by the Issuer of any certificates determined by

it to be required pursuant to Rule 903 under the Securities Act. Upon surrender to the Trustee of the Global Notes of such class held by DTC, accompanied by registration instructions from DTC for registration of Definitive Notes in the names of the Noteholders of such class, the Issuer shall issue and the Trustee shall authenticate and deliver the Definitive Notes of such class to the Agent Members and Beneficial Holders of such class or their nominees in accordance with the instructions of DTC.

None of the Issuer, the Registrar, the Paying Agent or the Trustee shall be liable for any delay in delivery of such instructions and may conclusively rely on, and shall be fully protected in relying on, such registration instructions. Upon the issuance of Definitive Notes of such class, the Trustee shall recognize the Persons in whose name the Definitive Notes are registered in the Register as Noteholders hereunder. Neither the Issuer nor the Trustee shall be liable if the Trustee or the Issuer is unable to locate a qualified successor to DTC.

Definitive Notes of any class will be freely transferable and exchangeable for Definitive Notes of the same class at the office of the Trustee or the office of a Registrar upon compliance with the requirements set forth herein. In the case of a transfer of only part of a holding of Definitive Notes, a new Definitive Note shall be issued to the transferee in respect of the part transferred and a new Definitive Note in respect of the balance of the holding not transferred shall be issued to the transferor and may be obtained at the office of the applicable Registrar.

(c) Any Beneficial Interest in one of the Global Notes as to any class that is transferred to a Person who takes delivery in the form of an interest in another Global Note will, upon transfer, cease to be an interest in such Global Note and become an interest in such other Global Note and, accordingly, will thereafter be subject to all transfer restrictions, if any, and other procedures applicable to beneficial interests in such other Global Note for as long as it remains such an interest.

(d) Any Definitive Note delivered in exchange for an interest in a Permanent Global Note pursuant to paragraph (b) of this Section shall, except as otherwise provided by paragraph (f) of Section 2.11, bear the Private Placement Legend applicable to a Permanent Global Note set forth in Section 2.02 hereof.

(e) Any Definitive Note delivered in exchange for an interest in a Regulation S Global Note pursuant to paragraph (b) of this Section shall, except as otherwise provided by paragraph (f) of Section 2.11, bear the Private Placement Legend applicable to a Regulation S Global Note set forth in Section 2.02 hereof.

(f) Upon the request of the Servicer from time to time, the Trustee shall request DTC to provide a list of the Agent Members holding Beneficial Interests in the Notes on such Record Date and shall provide such list to the Servicer. Any cost involved in obtaining such list shall be included in the Expenses to be reimbursed on the next succeeding Payment Date. Not later than five Business Days prior to each Payment Date or any other date on which a Distribution Report is to be distributed pursuant to Section 2.13(a) to Agent Members and Beneficial Holders, the Servicer shall provide a list to the Trustee of the Agent Members, Beneficial Holders and Noteholders (other than DTC or its nominee or any other depositary) that have provided Confidentiality Agreements to the Issuer, and the Trustee shall distribute such reports only to the Agent Members, Beneficial Holders and Noteholders named on such list.

Section 2.11 Special Transfer Provisions. (a) Transfers to Non-QIB Institutional Accredited Investors. The following provisions shall apply with respect to the registration of any proposed transfer of a Note (other than a Temporary Regulation S Global Note) to any Institutional Accredited Investor which is not a QIB (excluding Non-U.S. Persons):

(i) The Registrar shall register the transfer of any Note, whether or not such Note bears the Private Placement Legend, if the proposed transferee has delivered to the Registrar (A) a certificate substantially in the form of Exhibit K hereto, (B) an Opinion of Counsel acceptable to the Issuer that such transfer is in compliance with the Securities Act, (C) a Confidentiality Agreement duly executed by such transferee, and (D) so long as the License Agreement has not been terminated, appropriate certification that such transferee is not engaged in, and is not an Affiliate of a Person engaged in, the business of developing, manufacturing or marketing pharmaceutical or diagnostic products.

(ii) If the proposed transferor is an Agent Member holding a beneficial interest in the Permanent Global Note, upon receipt by the Registrar of (x) the documents, if any, required by paragraph (i), including the Confidentiality Agreement, and (y) instructions given in accordance with DTC’s and the Registrar’s procedures, the Registrar shall reflect on its books and records the date and a decrease in the

principal amount of the Permanent Global Note in an amount equal to the principal amount of the beneficial interest in the Permanent Global Note to be transferred, and the Issuer shall execute, and the Trustee shall authenticate and deliver, one or more Definitive Notes of like tenor and amount.

(b) Transfers to QIBs. The following provisions shall apply with respect to the registration of any proposed transfer of an interest in a Permanent Global Note or a Definitive Note issued in exchange for an interest in such Permanent Global Note in accordance with Section 2.10(b) hereof to a QIB (excluding Non-U.S. Persons):

(i) If the Note to be transferred consists of (x) Definitive Notes, the Registrar shall register the transfer if such transfer is being made by a proposed transferor who has checked the box provided for on the form of Note stating, or has otherwise advised the Issuer and the Registrar in writing, that the sale has been made in compliance with the provisions of Rule 144A to a transferee who has signed the certification provided for on the form of Note stating, or has otherwise advised the Issuer and the Registrar in writing, that (A) it is purchasing the Note for its own account or an account with respect to which it exercises sole investment discretion and that it and any such account are QIBs within the meaning of Rule 144A, (B) it is or such QIBs are aware that the sale to it is being made in reliance on Rule 144A and acknowledge that it has received such information regarding the Issuer as it has requested pursuant to Rule 144A or has determined not to request such information and (C) it is or such QIBs are aware that the transferor is relying upon its foregoing representations in order to claim the exemption from registration provided by Rule 144A, (D) it and all such QIBs have duly executed and delivered to the Issuer a Confidentiality Agreement, and (E), so long as the License Agreement has not been terminated, neither it nor any such QIBs is engaged in, or is an Affiliate of a Person engaged in, the business of developing, manufacturing or marketing pharmaceutical or diagnostic products or (y) an interest in a Permanent Global Note, the transfer of such Beneficial Interest may be effected only through the book-entry system maintained by DTC and to the extent provided in the agreement with DTC, and in each case, each transferee and QIB has delivered to the Registrar a Confidentiality Agreement duly executed by such transferee and QIB, respectively.

(ii) If the proposed transferee is an Agent Member, and the Note to be transferred is a Definitive Note, upon receipt by the Registrar of the documents referred to in clause (i), including the Confidentiality Agreement, and instructions given in accordance with DTC’s and the Registrar’s procedures, the Registrar shall reflect on its books and records the date and an increase in the principal amount at maturity of the Permanent Global Note in an amount equal to the principal amount at maturity of the Definitive Note to be transferred, and the Trustee shall cancel the Definitive Note so transferred (upon written direction from the Registrar if different from the Trustee).

(c) Transfers of Interests in a Temporary Regulation S Global Note. The following provisions shall apply with respect to registration of any proposed transfer of interests in a Temporary Regulation S Global Note:

(i) The Registrar shall register the transfer of any Beneficial Interest in a Temporary Regulation S Global Note (x) if the proposed transferee is a Non-U.S. Person and the proposed transferor has delivered to the Registrar a certificate substantially in the form of Exhibit J hereto and has delivered to the Issuer a duly executed Confidentiality Agreement or (y) if the proposed transferee is a QIB and the proposed transferor has checked the box provided for on the form of Note stating, or has otherwise advised the Issuer and the Registrar in writing, that the sale has been made in compliance with the provisions of Rule 144A to a transferee who has signed the certification provided for on the form of Note stating, or has otherwise advised the Issuer and the Registrar in writing, that (A) it is purchasing the Note for its own account or an account with respect to which it exercises sole investment discretion and that it and any such account are QIBs within the meaning of Rule 144A, (B) it is or such QIBs are aware that the sale to them is being made in reliance on Rule 144A and acknowledge that they have received such information regarding the Issuer as they have requested pursuant to Rule 144A or have determined not to request such information, (C) it is or such QIBs are aware that the transferor is relying upon their foregoing representations in order to claim the exemption from registration provided by Rule 144A, (D) it and all such QIBs have duly executed and delivered to the Issuer a Confidentiality Agreement and (E), so long as the License Agreement has not been terminated, neither it nor any such QIBs is engaged in, or is an Affiliate of a Person engaged in, the business of developing, manufacturing or marketing pharmaceutical or diagnostic products.

(ii) If the proposed transferee is an Agent Member that provides the documents referred to in clause (i)(y) above, including the Confidentiality Agreement, upon receipt by the Registrar of such documents and instructions given in accordance with DTC’s and the Registrar’s procedures, the Registrar shall reflect on its books and records the date and an increase in the principal amount of the Permanent Global Note of the relevant class, in an amount equal to the principal amount of the Temporary Regulation S Global Note of such class to be transferred, and the Trustee shall decrease the amount of the Temporary or Permanent Regulation S Global Note of such class (upon written direction from the Registrar if different from the Trustee).

(e) Transfers to Non-U.S. Persons at any Time. The following provisions shall apply with respect to any transfer of a Note to a Non-U.S. Person:

(i) Prior to the applicable Regulation S Global Notes Exchange Date, the Registrar shall not register any proposed transfer of a Note to a Non-U.S. Person pursuant to Rule 904 of Regulation S.

(ii) The Registrar shall register any proposed transfer of a Note to any Non-U.S. Person if the Note to be transferred is a Definitive Note or an interest in a Permanent Global Note, upon receipt of a certificate substantially in the form of Exhibit J from the proposed transferor and a Confidentiality Agreement duly executed by such Non-U.S. Person.

(iii) (a) If the proposed transferor is an Agent Member holding a Beneficial Interest in a Permanent Global Note, upon receipt by the Registrar of (x) the documents, if any, required by paragraph (ii) and (y) instructions in accordance with DTC’s and the Registrar’s procedures, the Registrar shall reflect on its books and records the date and a decrease in the principal amount of a Permanent Global Note in an amount equal to the principal amount of the beneficial interest in such Permanent Global Note to be transferred, and (b) if the proposed transferee is an Agent Member, upon receipt by the Registrar of instructions given in accordance with DTC’s and the Registrar’s procedures, the Registrar shall reflect on its books and records the date and an increase in the principal amount of the Regulation S Global Note of the relevant class in an amount equal to the principal amount of the beneficial interest in such Permanent Global Note or any Definitive Notes issued in exchange for such interest in such Permanent Global Note to be transferred, and the Trustee shall cancel the Definitive Note, if any, so transferred or decrease the amount of the Permanent Global Note (upon written direction from the Registrar if different from the Trustee).

(f) Private Placement Legend. Upon the transfer, exchange or replacement of Notes bearing the Private Placement Legend, the Registrar shall deliver only Notes that bear the Private Placement Legend unless there is delivered to the Registrar an Opinion of Counsel reasonably satisfactory to the Issuer and the Trustee to the effect that neither such legend nor the related restrictions on transfer are required in order to maintain compliance with the provisions of the Securities Act or any other obligations of the Issuer, including the obligation in respect of the Royalty Rights to have any Noteholder execute a Confidentiality Agreement.

(g) General. By its acceptance of any Note bearing the Private Placement Legend, each Holder of such Note acknowledges the restrictions on transfer of such Note set forth in this Indenture and in the Private Placement Legend and agrees that it will transfer such Note only as provided in this Indenture. The Registrar shall not register a transfer of any Note unless such transfer complies with the restrictions on transfer of such Note set forth in this Indenture. In connection with any transfer of Notes, each Holder agrees by its acceptance of the Notes to furnish the Trustee the certifications and legal opinions described herein to confirm that such transfer is being made pursuant to an exemption from, or a transaction not subject to, the registration requirements of the Securities Act; provided that the Trustee shall not be required to determine (but may rely on a determination made by the Issuer with respect to) the sufficiency of any such legal opinions. Each Holder also agrees that it will not take any action to transfer any Note to a transferee without causing such transferee to execute and deliver a Confidentiality Agreement. The Trustee shall promptly deliver to the Issuer the executed version of each executed Confidentiality Agreement that it receives, provided that the Trustee shall retain a copy of each such Confidentiality Agreement in its records relating to the Notes.

(h) No Listing. The Notes shall be issued pursuant to an exemption from registration under the Securities Act. The Issuer agrees that it will not at any time (i) apply to list, list or list upon notice of issuance, (ii) consent to or authorize an application for the listing or the listing of, or (iii) enable or authorize the trading of the Notes on an established securities market, including (w) a national securities exchange registered under the Exchange Act or exempted from registration because of the limited volume of transactions; (x) a foreign securities exchange that, under the law of the jurisdiction where it is organized, satisfies regulatory requirements that are analogous to the regulatory requirements under the Exchange Act applicable to exchanges described in subclause (w); (y) a regional or local exchange; or (z) an over-the-counter market, as the term “established securities market” and the terms in subclauses (w), (x), (y) and (z) are defined for purposes of Section 7704 of the Code.

The Trustee shall retain copies of all letters, notices and other written communications received pursuant to Section 2.10 hereof or this Section 2.11. The Issuer shall have the right to inspect and make copies of all such letters, notices, Confidentiality Agreements or other written communications at any reasonable time upon the giving of reasonable written notice to the Trustee.

Section 2.12 Temporary Definitive Notes. Pending the preparation of Definitive Notes of any class, the Issuer may execute and the Trustee may authenticate and deliver temporary Definitive Notes of such class which are printed, lithographed, typewritten or otherwise produced, in any denomination, containing substantially the same terms and provisions as are set forth in the applicable exhibit hereto or in any indenture supplemental hereto, except for such appropriate insertions, omissions, substitutions and other variations relating to their temporary nature as the Manager of the Issuer executing such temporary Definitive Notes may determine, as evidenced by his execution of such temporary Definitive Notes.

If temporary Definitive Notes of any class are issued, the Issuer will cause such Definitive Notes of such class to be prepared without unreasonable delay. After the preparation of Definitive Notes of such class, the temporary Definitive Notes shall be exchangeable for Definitive Notes upon surrender of such temporary Definitive Notes at the Corporate Trust Office of the Trustee, without charge to the Holder thereof. Upon surrender for cancellation of any one or more temporary Definitive Notes of any class, the Issuer shall execute and the Trustee shall authenticate and deliver in exchange therefor Definitive Notes of like class, in authorized denominations and in the same aggregate principal amounts. Until so exchanged, such temporary Definitive Notes shall in all respects be entitled to the same benefits under this Indenture as Definitive Notes.

Section 2.13 Statements to Noteholders. (a) (i) On each Payment Date and any other date for distribution of any payments with respect to any class of Notes then Outstanding, the Trustee shall deliver a report, substantially in the form attached as Exhibit H hereto and prepared by the Servicer, giving effect to such payments (each, a “Distribution Report”), to each Agent Member, Beneficial Holder and Noteholder included on the list provided by the Servicer pursuant to Section 2.10(f), provided that the Servicer shall have advised the Trustee in writing not later than the last Business Day preceding such Payment Date that Amgen has filed its applicable periodic report with the SEC relating to the calendar quarter immediately preceding such Payment Date. If the Trustee does not receive the written notice referred to in the proviso in the preceding sentence by the close of business on such last Business Day preceding a Payment Date, the Trustee shall not distribute the Distribution Report to the Agent Members, Beneficial Holders and the Noteholders included on the list provided by the Servicer pursuant to Section 2.10(f) on such Payment Date, and the Trustee shall not distribute such Distribution Report until promptly after the Servicer advises the Trustee in writing that Amgen has filed such report. The Trustee shall deliver a copy of each Distribution Report to each Agent Member, Beneficial Holder and Noteholder included on the list provided by the Servicer pursuant to Section 2.10(f) and to the Issuer and NPS and to no other Person. The Trustee shall not distribute the Distribution Report to DTC, and each other Noteholder, Agent Member and Beneficial Holder shall be entitled to receive the Distribution Report only if such Noteholder, Agent Member or Beneficial Holder has executed and delivered a Confidentiality Agreement to the Issuer.

(ii) Each Distribution Report provided to each Agent Member and Beneficial Holder for each Payment Date, commencing March 30, 2005, shall be accompanied by (i) a statement prepared by the Servicer setting forth an analysis of the Collection Account activity for the Interest Accrual Period ending on the related Reference Date, (ii) such information, if any, regarding the License Agreement and the Licensed Technology as NPS shall have provided to the Servicer on behalf of the Trustee pursuant to Section 6.4 of the Purchase and Sale Agreement during the Interest Accrual Period then ended and (iii) the information included in all reports that the Issuer shall have provided to the Servicer on behalf of the Trustee pursuant to Section 5.03 hereof during the Interest Accrual Period then ended. Each annual Distribution Report provided to each Noteholder for each March 30, commencing March 30, 2006, shall include the information described in the preceding sentence and also be accompanied by (x) a

statement, prepared by the Servicer, setting forth an analysis of the Collection Account activity for the calendar year ended the preceding December 31 and (y) a comparison, prepared by the Servicer, of the actual cumulative amortization of the Class A Notes through such December 31 against the Base Case Amortization Schedule on the Class A Notes through such December 31.

(b) After the end of each calendar year but not later than the latest date permitted by law, the Trustee shall (or shall instruct any Paying Agent to) furnish to each Person who at any time during such calendar year was a Noteholder of record of any class of Notes, a statement (for example, a Form 1099 or any other means required by law) prepared by the Trustee containing the sum of the amounts determined pursuant to Exhibit H hereto with respect to the class of Notes for such calendar year or, in the event such Person was a Noteholder of record of any class of Notes during only a portion of such calendar year, for the applicable portion of such calendar year, and such other items as are readily available to the Trustee and which a Noteholder shall reasonably request as necessary for the purpose of such Noteholder’s or holder’s, as applicable, preparation of its U.S. federal income or other tax returns. So long as any of the Notes are registered in the name of DTC or its nominee, such report and such other items will be prepared on the basis of such information supplied to the Trustee by DTC and the Agent Members, and will be delivered by the Trustee to DTC and by DTC to the applicable beneficial owners in the manner described above. In the event that any such information has been provided by any Paying Agent directly to such Person through other tax-related reports or otherwise, the Trustee in its capacity as Paying Agent shall not be obligated to comply with such request for information. For the avoidance of doubt, the Trustee shall not be obligated to provide any statements, reports or other items under this Section 2.13(b) to any Agent Member or Beneficial Holders on the list of Agent Members, Beneficial Holders and Noteholders included on the list provided by the Servicer pursuant to Section 2.10(f) that is not a Noteholder.

(c) At such time, if any, as the Notes of any class are issued in the form of Definitive Notes, the Trustee shall prepare and deliver the information described in Section 2.13(b) to each Holder of record of a Definitive Note of such class for the relevant period of beneficial ownership of such Definitive Note as appears on the records of the Trustee, subject to the Issuer having confirmed in writing that each such Holder has executed and delivered to the Issuer a Confidentiality Agreement.

(d) The Trustee shall be at liberty to sanction any method of giving notice to the Noteholders of any class if, in its opinion, such method is reasonable, having regard to the number and identity of the Noteholders of such class and/or to market practice then prevailing, is in the best interests of the Noteholders of such class, and any such notice shall be deemed to have been given on such date as the Trustee may approve; provided that notice of such method is given to the Noteholders of such class in such manner as the Trustee shall require.

(e) Not later than 1:00 p.m., New York City time, on the last Business Day preceding each Payment Date, the Servicer on behalf of the Issuer shall provide the Trustee with a statement regarding the amounts of principal, interest and Premium included in the amounts being distributed to Noteholders pursuant to Section 3.07 on such Payment Date, and the Trustee shall include a copy of such statement with each distribution to a Noteholder (including DTC) made pursuant to Section 3.07. Each such statement shall include a notice to the effect that the tax treatment of any Premium payment may differ from the interest payment, and may include a withholding obligation.

Section 2.14 CUSIP, CINS AND ISIN Numbers. The Issuer in issuing the Notes may use “CUSIP”, “CINS”, “ISIN” or other identification numbers (if then generally in use), and if so, the Trustee shall use CUSIP numbers, CINS numbers, ISIN numbers or other identification numbers, as the case may be, in notices of redemption or exchange as a convenience to Holders; provided that any such notice shall state that no representation is made as to the correctness of such numbers either as printed on the Notes or as contained in any notice of redemption or exchange and that reliance may be placed only on the other identification numbers printed on the Notes; provided further, that failure to use “CUSIP”, “CINS”, “ISIN” or other identification numbers in any notice of redemption or exchange shall not affect the validity or sufficiency of such notice.

Section 2.15 Refinancing Notes. (a) Subject to paragraphs (b) and (c) below and Section 5.02(d) hereof, the Issuer may issue Refinancing Notes pursuant to this Indenture for the purpose of refinancing all of the Outstanding Principal Balance of any class of Notes (including a refinancing of Refinancing Notes). Each refinancing of any class of Notes with the proceeds of an offering of Refinancing Notes (a “Refinancing”) shall be authorized pursuant to one or more Board Resolutions. Each Refinancing Note shall be designated generally as a “Note” for all purposes under this Indenture, with such further designations added or incorporated in such title as specified in the related Board Resolutions or in any indenture supplemental hereto providing for the issuance of such Notes or specified in the form of such Notes, as the case may be. The Refinancing Notes shall be issued on the Payment Date on which the Redemption in whole of the class of Notes being refinanced is to occur as provided in Section 3.10.

(b) A Refinancing of any class of Notes shall be effected as a Redemption pursuant to Section 3.09 hereof, provided that a Refinancing of the Class A Notes shall be effected as an Optional Redemption pursuant to Section 3.09(a) hereof. On the date of any Refinancing, the Issuer shall issue and sell an aggregate principal amount of Refinancing Notes in an amount not less than the sum of the Redemption Price of the Notes being refinanced thereby plus the Refinancing Expenses relating thereto and any Redemption Premium plus any amount to be deposited in an Interest Reserve Account for such Refinancing Notes. The proceeds of each sale of Refinancing Notes shall be used to make the deposit required by Section 3.10(b) hereof, to pay such Refinancing Expenses, to fund such Interest Reserve Account and/or deposit and for such other purposes, if any, as shall be specified in the Board Resolution authorizing the issuance such Refinancing Notes. Once a notice of a Redemption in respect of any Refinancing is published in accordance with Section 3.10(a), each class of Notes to which such notice applies shall become due and payable on the Refinancing Date stated in such notice at their Redemption Price.

(c) Each Refinancing Note shall contain such terms as may be established in or pursuant to the related Board Resolutions (subject to Section 2.01 hereof) or in any indenture supplemental hereto providing for the issuance of such Notes or specified in the form of such Notes to the extent permitted below, and shall have the same ranking pursuant to Section 3.07 with respect to all other Outstanding Notes as the Notes being refinanced thereby. No less than seven (7) Business Days prior to the issuance of any Refinancing Notes, any or all of the following, as applicable, with respect to the related issue of Refinancing Notes shall have been determined by the Issuer and set forth in such Board Resolutions or in any indenture supplemental hereto providing for the issuance of such Notes or specified in the form of such Notes, as the case may be:

(2) the aggregate principal amount of each class of Refinancing Notes which may be issued in respect of such Refinancing;

(4) if applicable, the Base Case Final Payment Date and the Final Maturity Date of each class of such Refinancing Notes;

(5) the rate at which such Refinancing Notes shall bear interest or the method by which such rate shall be determined;

(6) the denomination or denominations in which any class of such Refinancing Notes shall be issuable;

(7) whether any such Refinancing Notes are to be issuable initially in temporary or permanent global form and, if so, whether beneficial owners of interests in any such permanent global Refinancing Note may exchange such interests for Refinancing Notes of such class and of like tenor of any authorized form and denomination and the circumstances under which any such exchanges may occur, if other than in the manner provided in Section 2.07 hereof, and the circumstances under which and the place or places where any such exchanges may be made and the identity of any initial depository therefor; and

(8) any other terms, conditions, rights and preferences (or limitations on such rights and preferences) relating to the class of Refinancing Notes (which terms shall comply with Applicable Law and not be inconsistent with the requirements or restrictions of this Indenture).

(d) If any of the terms of any issue of Refinancing Notes are established by action taken pursuant to one or more Board Resolutions, such Board Resolutions shall be delivered to the Trustee setting forth the terms of such Refinancing Notes.

Section 2.16 Class B Notes. (a) Subject to paragraph (b) below and Section 5.02(d) hereof, the Issuer may issue Class B Notes pursuant to this Indenture (a “Class B Issuance”), including for the purpose of funding a redemption of the Class A Notes, in whole or in part. Each Class B Issuance shall be authorized pursuant to one or

more Board Resolutions. Each Class B Note shall be designated generally as a “Note” for all purposes under this Indenture. Each Class B Note shall have such further designations added or incorporated in such title as specified in the related Board Resolutions or in any indenture supplemental hereto providing for the issuance of such Notes or specified in the form of such Notes, as the case may be. If the proceeds of the Class B Notes are being used to redeem the Class A Notes, in whole or in part, the Class B Notes shall be issued on the Payment Date on which the Optional Redemption in whole of the Class A Notes being refinanced is to occur as provided in Section 3.10.

(b) If the proceeds of the Class B Notes are being used to redeem any Class A Notes, such redemption shall be effected as an Optional Redemption pursuant to Section 3.09 hereof. On the date of any such Optional Redemption, the Issuer shall issue and sell an aggregate principal amount of Class B Notes in an amount not less than the sum of the Redemption Price of the Notes being refinanced thereby and any Redemption Premium plus the Transaction Expenses relating thereto plus any amount to be deposited in an Interest Reserve Account for the Class B Notes. The proceeds of each sale of Class B Notes shall be used to make the deposit required by Section 3.10(b) hereof, if applicable, to pay such Transaction Expenses, to fund any Interest Reserve Account and/or deposit and for such other purposes, if any, as shall be specified in the Board Resolution authorizing the issuance such Class B Notes. Once a notice of Redemption in respect of any Class B Issuance is published in accordance with Section 3.10(a), each class of Notes to which such notice applies shall become due and payable on the Redemption Date stated in such notice at their Redemption Price.

(c) Each Class B Note shall contain such terms as may be established in or pursuant to the related Board Resolutions (subject to Section 2.01 hereof) or in any indenture supplemental hereto providing for the issuance of such Notes or specified in the form of such Notes to the extent permitted below, and shall be subordinate to the Class A Notes to the extent provided in this Indenture. No less than seven (7) Business Days prior to the issuance of the Class B Notes, any or all of the following, as applicable, with respect to the related Class B Issuance shall have been determined by the Issuer and set forth in such Board Resolutions or in any indenture supplemental hereto or specified in the form of such Class B Notes, as the case may be, with respect to the Class B Notes to be issued:

(1) the aggregate principal amount of any such Class B Notes which may be issued;

(3) if applicable, the Base Case Final Payment Date and the Final Maturity Date of any such Class B Notes;

(4) whether any such Class B Notes are to have the benefit of any reserve account and, if so, the amount and terms thereof;

(5) the rate at which such Class B Notes shall bear interest or the method by which such rate shall be determined;

(6) the denomination or denominations in which such Class B Notes shall be issuable;

(7) whether any such Class B Notes are to be issuable initially in temporary or permanent global form and, if so, whether beneficial owners of interests in any such permanent global Class B Note may exchange such interests for Class B Notes of like tenor and of any authorized form and denomination and the circumstances under which any such exchanges may occur, if other than in the manner provided in Section 2.07 hereof, and the circumstances under which and the place or places where any such exchanges may be made and the identity of any initial depository therefor; and

(8) any other terms, conditions, rights and preferences (or limitations on such rights and preferences) relating to Class B Notes (which terms shall comply with Applicable Law and not be inconsistent with the requirements or restrictions of this Indenture, including Sections 5.02(d) and 12.13 hereof).

(d) If any of the terms of any issue of Class B Notes are established by action taken pursuant to one or more Board Resolutions, such Board Resolutions shall be delivered to the Trustee setting forth the terms of such Class B Notes.

Section 2.17 Contingent Payment Status. Each Holder, by its acceptance of a Class A Note, agrees (i) that for U.S. federal income tax purposes, the Class A Notes will be treated as indebtedness subject to U.S. Treasury regulations governing contingent payment debt instruments; (ii) that the Holders of such Class A Notes will report original issue discount and interest on the Class A Notes in accordance with the Issuer’s determination of both the “comparable yield” and the “projected payment schedule,” and (iii) that the Holders will be bound by the Issuer’s application of the U.S. Treasury regulations that govern contingent payment debt instruments. For this purpose, the “comparable yield” for the Class A Notes and the “projected payment schedule” may be obtained by contacting the Issuer, attention: Assistant Treasurer, at the address set forth in Section 12.05.

Section 3.01 Establishment of Accounts. (a) The Servicer, acting on behalf of the Issuer, shall establish and maintain with the Operating Bank on its books and records in the name of the Issuer, subject to the lien in favor of the Trustee established by this Indenture, (i) a Collection Account (the “Collection Account”), (ii) an interest reserve account (the “Interest Reserve Account”), (iii) if applicable, a redemption account (the “Redemption Account”), (iv) if applicable, an escrow account (the “Escrow Account”), (iv) if applicable, a capital contribution account (the “Capital Account”), and (v) any additional accounts the establishment of which is set forth in a Board Resolution delivered to the Trustee, in each case at such time as is set forth in this Section 3.01 or in such Board Resolution. Each Account shall be established and maintained as an Eligible Account so as to create, perfect and establish the priority of the security interest of the Trustee in such Account and all cash, Eligible Investments and other property from time to time deposited therein and otherwise to effectuate the lien of the Indenture Estate.

(b) Withdrawals and Transfers; Control. The Trustee shall have sole dominion and control over the Accounts (including, inter alia, the sole power to direct withdrawals or transfers from the Accounts and to direct the investment and reinvestment of funds in the Accounts, subject to Section 3.02). The Trustee shall make withdrawals and transfers from the Accounts in accordance with the terms of this Indenture based on the Relevant Information and as calculated by it pursuant to this Indenture. The Issuer, the Servicer and the Trustee acknowledge that the Accounts are “deposit accounts” or “investment property” within the meaning of Section 9-102 of the UCC and that the Trustee has “control,” for purposes of Section 9-315 of the UCC, of Accounts that are maintained with the Trustee as the Operating Bank. The Issuer and the Servicer agree that, if any Account is established or maintained with any Operating Bank other than the Trustee, the Issuer and the Servicer shall cause such Operating Bank to enter into an agreement with the Trustee, the Issuer and the Servicer pursuant to which such Operating Bank agrees to comply with instructions originated by the Trustee directing the disposition, investment and reinvestment of funds in all Accounts maintained with such Operating Bank without the further consent of the Issuer or the Servicer and shall take such other actions as are reasonably required by the Trustee to establish its “control,” for purposes of Section 9-315(a) of the UCC, over any such Accounts.

(c) Eligible Accounts. If, at any time, any Account ceases to be an Eligible Account, the Servicer or an agent thereof shall, within 10 Business Days, establish a new account meeting the conditions set forth in this Section 3.01 in respect of such Account and transfer any cash or investments in the existing Account to such new account; and from the date such new collection account is established, it shall have the same designation as the existing Account. If the Operating Bank should change at any time, then the Servicer, acting on behalf of the Issuer, shall thereupon promptly establish replacement accounts as necessary at the successor Operating Bank and transfer the balance of funds in each Account then maintained at the former Operating Bank pursuant to the terms of the Purchase and Sale Agreement to such successor Operating Bank.

(d) Collection Account. The Servicer shall establish and maintain the Collection Account not later than the Closing Date, and the Collection Account shall bear a designation clearly indicating that the funds deposited therein are held for the benefit of the Secured Parties. Except as expressly provided herein, all Collections shall be deposited in the Collection Account and transferred therefrom in accordance with the terms of this Indenture. No funds shall be deposited in the Collection Account that do not constitute Collections except as expressly provided in this Indenture without the prior written consent of the Trustee.

(e) Interest Reserve Accounts. The Servicer shall establish and maintain an Interest Reserve Account for the Class A Notes not later than the Closing Date and the Interest Reserve Account shall bear a

designation clearly indicating that the funds deposited therein are held for the benefit of the Class A Noteholders. The Interest Reserve Amount shall be held in the Interest Reserve Account and disbursed as provided in Section 3.07 hereof. An Interest Reserve Account may be established and maintained in respect of any Refinancing Notes or Class B Notes for the benefit of the Holders of such Notes to the extent provided in the Board Resolutions authorizing the issuance of such Refinancing Notes or Class B Notes.

(f) Redemption Account. Upon receipt of notice of al Redemption of any class of Notes, the Servicer shall establish and maintain a Redemption Account at the Operating Bank in the name of the Trustee for the benefit of the Holders of Notes that are the subject of such Redemption. All amounts received for the purpose of any such Redemption shall be deposited in such Redemption Account and shall be held in such Account until such amounts are applied to pay the Redemption Price of such Notes and such Notes are cancelled by the Trustee.

(g) Escrow Account. Upon a determination by the Trustee that any Noteholder, Agent Member or Beneficial Holder has not delivered a Confidentiality Agreement to the Issuer, the Servicer shall establish and maintain the Escrow Account at the Operating Bank in the name of the Trustee for the benefit of any such Noteholder, Agent Member or Beneficial Holder. All amounts withheld pursuant to Section 2.05(d) shall be deposited in such Escrow Account and shall be held in such Account until such amounts are distributed as provided in that section.

(h) Capital Account. Upon the receipt of any capital contribution from NPS to the Issuer, the Servicer shall establish and maintain the Capital Account at the Operating Bank in the name of the Trustee for the benefit of the Secured Parties. All such capital contributions shall be deposited in such Capital Account and shall be held in such Account and transferred (i) to the Collection Account only to the extent permitted by Section 3.07 and (ii) to the Redemption Account only to the extent specifically provided for in any notice of an Optional Redemption delivered to the Trustee pursuant to Section 3.09(a).

Section 3.02 Investments of Cash. For so long as any Notes remain Outstanding, the Trustee, at the direction of the Servicer, shall, or shall direct the Eligible Institution holding each Account in writing, to invest and reinvest the funds on deposit in the Accounts in Eligible Investments; provided, however, that so long as an Event of Default has occurred and is continuing, the Trustee shall invest such amount in Eligible Investments described in clause (d) of the definition thereof from the time of receipt thereof until such time as such amounts are required to be distributed pursuant to the terms of this Indenture. In the absence of written direction delivered to the Trustee from the Servicer, the Trustee shall invest any funds in Eligible Investments described in clause (d) of the definition thereof. The Trustee shall make such investments and reinvestments in accordance with the terms of the following provisions:

(i) the Eligible Investments shall have maturities and other terms such that sufficient funds shall be available to make required payments pursuant to this Indenture on the Business Day immediately preceding the first Payment Date after which such investment is made, in the case of investments of funds on deposit in the Collection Account; and

(ii) if any funds to be invested are not received in the Accounts by 1:00 p.m., New York City time, on any Business Day, such funds shall, if possible, be invested in overnight Eligible Investments.

The Issuer acknowledges that regulations of the U.S. Comptroller of the Currency grant the Issuer the right to receive confirmations of security transactions as they occur. The Issuer specifically waives receipt of such confirmations to the extent permitted by law and acknowledges that the Trustee will furnish periodic cash transaction statements which will detail all investment transactions.

Section 3.03 Closing Date Deposits, Withdrawals and Transfers. (a) On the Closing Date, the Trustee shall, subject to the receipt of written direction from the Issuer upon receipt of the proceeds of the sale by the Issuer of the Notes, make the following payments and transfers to the Accounts from such proceeds:

(i) pay to such Persons as shall be specified by the Issuer such Transaction Expenses as shall be due and payable in connection with the issuance and sale of the Notes;

(ii) pay the initial Hedge Payment to the Hedge Provider, if directed by the Issuer;

(iii) deposit into the Interest Reserve Account an amount equal to the Interest Reserve Amount; and

(iv) remit to NPS, in accordance with the Purchase and Sale Agreement, an amount equal to the cash portion of the Purchase Price as specified therein.

(b) On the date of issuance of any Refinancing Notes or Class B Notes, the Trustee shall, subject to the receipt of written direction from the Issuer upon receipt of the proceeds of the sale by the Issuer of such Notes, make such payments and transfers as shall be specified in the related Board Resolution and any supplemental indenture in respect of such Notes.

Section 3.04 Capital Contributions; Interest Reserve Amount. (a) The Issuer may accept capital contributions made by NPS, provided that such capital contributions are deposited by Issuer in the Capital Account.

(b) On the Payment Date scheduled for December 30, 2006, the Trustee shall transfer to the Collection Account the balance, if any, remaining in the Interest Reserve Account after the payment of the Interest Amount on the Class A Notes for such Payment Date, and the amount so transferred shall be included in the Available Collections Amount for such Payment Date.

Section 3.05 Calculation Date Calculations. (a) Calculation of Certain Amounts. As soon as reasonably practicable after each Calculation Date, but in no event later than 12:00 noon (New York, New York time) on the second Business Day prior to the immediately succeeding Payment Date, the Trustee shall, based on information known to it or Relevant Information provided to it, determine the Collections received during the period commencing on the day next following the preceding Calculation Date and ending on such Calculation Date (including the amount of any investment earnings on the balance in the Interest Reserve Account and Collection Account as of such Calculation Date and any amount to be transferred pursuant to Sections 3.06 and 3.07 in respect of the immediately succeeding Payment Date) and shall calculate the following amounts:

(i) the balance of funds on deposit in each of the Collection Account and the Interest Reserve Account on such Calculation Date;

(ii) the Expenses payable on the Payment Date immediately succeeding such Calculation Date, consisting of all costs incurred by the Trustee and not previously reimbursed and the amounts shown on all invoices received from the Servicer for the reimbursement or payment of Expenses not previously paid or reimbursed;

(iii) the amount of the B&W Payment, if any, to be made on the Payment Date immediately succeeding such Calculation Date;

(v) any other information, determinations and calculations reasonably required in order to give effect to the terms of this Indenture and the Related Documents.

(b) Calculation of Interest Amounts. Not later than 12:00 noon (New York, New York time) on the second Business Day prior to each Payment Date, the following calculations or determinations with respect to Interest Amounts due on such Payment Date shall be performed or made by the Calculation Agent and provided to the Servicer:

(i) the applicable interest rate on each class of Floating Rate Notes based on LIBOR determined on the Reference Date for the Interest Accrual Period beginning on such Payment Date; and

(ii) the Interest Amount (including any Additional Interest) on each class of Floating Rate Notes and Fixed Rate Notes for such Payment Date.

(c) Calculation of Principal Payments. Not later than 12:00 noon (New York, New York time) on the second Business Day prior to each Payment Date, the Trustee shall calculate or determine the following with respect to principal payments due on such Payment Date:

(i) the Outstanding Principal Balance of each class of Notes on such Payment Date immediately prior to any principal payment on such date;

(ii) for each March 30 Payment Date, the Cash Sweep Principal Amount and the Cash Sweep Premium, if any; and

(iii) the amount of any other principal payment, if any, to be made in respect of each class of Notes on such Payment Date.

(d) Calculation of Redemption Amounts. Not later than 12:00 noon (New York, New York time) on the second Business Day prior to the Redemption Date on which a Redemption of Notes is scheduled to occur, the Trustee shall perform the calculations necessary to determine the Redemption Price of the Notes to be repaid on such Redemption Date, the Redemption Premium, if any, to be paid in addition to such Redemption Price and the amount of accrued and unpaid interest on the Notes being redeemed through the Redemption Date.

(e) Calculation of Shortfalls. Not later than 12:00 noon (New York, New York time) on the second Business Day prior to each Payment Date, the Trustee shall perform the calculations necessary to determine the following:

(i) the shortfall, if any, of the Available Collections Amount for such Payment Date in respect of the Interest Amount due to the Class A Noteholders pursuant to clause (ii) of Section 3.07(a) (a “Shortfall”), taking into account the payment of Expenses and any B&W Payment payable on such Payment Date; and

(ii) with respect to each Shortfall, the amount to be withdrawn from the Interest Reserve Account and/or the Capital Account, determined as provided in Section 3.07(a).

(f) Application of the Available Collections Amount. Not later than 1:00 p.m., New York City time, two Business Days prior to each Payment Date, the Trustee shall determine the amounts to be applied on such Payment Date to make each of the payments contemplated by Section 3.07(a) or 3.07(b), as applicable, setting forth separately, in the case of payments in respect of each class of Notes, the amount to be applied on such Payment Date to pay all Expenses and any B&W Payment due and payable on such date, and interest, principal and Premium, if any, on such class of Notes, all in accordance with Section 3.07.

(g) Reports. The Trustee shall provide to the Servicer the information described in Sections 3.05(a), (b), (c), (d), (e) and (f) to the Servicer, no later than 1:00 p.m., New York City time, two Business Days immediately preceding each Payment Date.

Section 3.06 Payment Date First Step Transfers. On each Payment Date, the Trustee shall transfer from any Account (other than the Collection Account, the Interest Reserve Account and the Capital Account) to the Collection Account the amount of earnings (net of losses and investment expenses), if any, on investments of funds on deposit therein during the preceding Interest Accrual Period.

Section 3.07 Payment Date Second Step Withdrawals. (a) On each Payment Date, after the transfers provided for in Section 3.06 have been made and after making the distributions, if any, pursuant to Section 3.07(b), the Trustee shall distribute the amounts set forth below in the order of priority set forth below but, in each case, only to the extent that all amounts then required to be paid ranking prior thereto (“Prior Ranking Amounts”) have been paid in full. Except as provided in clause (iv) of the definition of Collections and in clause (c) of the definition of Available Collections Amount, the Available Collections Amount does not include the aggregate amount of funds on deposit in the Interest Reserve Account and the Capital Account, provided that, if there is a Shortfall, then the Trustee shall withdraw from the Interest Reserve Account the lesser of the Shortfall and the Interest Reserve Account Balance and distribute it to the Class A Noteholders in payment of the Interest Amount, and provided further that, if the amount available in the Interest Reserve Account is less than the amount of such Shortfall, and there is a positive balance in the Capital Account, the Trustee shall withdraw from the Capital Account an amount equal to the lesser of the excess of the Shortfall over the amount, if any, withdrawn from the Interest Reserve Account and the balance in the Capital Account and distribute it to the Class A Noteholders in payment of the Interest Amount, and provided further that the Trustee shall make such a withdrawal from the Capital Account in respect of not more than six (6) Payment Dates in total prior to the Final Maturity Date of the Notes and in respect of

not more than any three consecutive Payment Dates. Except for such withdrawals, the amounts set forth below are to be paid out of the Available Collections Amount:

(i) First, to the payment of Expenses to such Persons as shall be entitled to payment or reimbursement thereof and to the payment of any B&W Payment, if required pursuant to Section 3.08;

(ii) Second, to the Class A Noteholders, the Interest Amount on the Class A Notes;

(iii) Third, on each March 30 Payment Date, to the Class A Noteholders, the Cash Sweep Principal Amount and the Cash Sweep Premium, if any, allocated pro rata in proportion to the outstanding principal balance of the Class A Notes held by such Class Noteholders, until the Class A Notes have been paid in full;

(iv) Fourth, on each Payment Date other than the March 30 Payment Date and the Final Maturity Date, the Net Available Collections Amount shall be retained in the Collection Account, until the Class A Notes have been paid in full;

(v) Fifth, to the payment of principal on the Class A Notes until the Class A Notes have been paid in full;

(vi) Sixth, to the Class B Noteholders, if any, the Interest Amount on the Class B Notes;

(vii) Seventh, to the Class B Noteholders, payment of the principal amount of the Class B Notes until the Class B Notes have been paid in full; and

(b) Redemption. On any Payment Date on which any class of Notes is to be the subject of a Redemption, in whole or in part, the Trustee shall distribute the amounts in the applicable Redemption Account as provided herein and in the applicable Board Resolutions, including the following:

(i) pay to such Persons as shall be specified by the Issuer such Transaction Expenses as shall be due and payable in connection with the issuance and sale of the applicable Refinancing Notes or Class B Notes;

(ii) deposit into an Interest Reserve Account, if applicable, an amount equal to the Interest Reserve Amount;

(iii) remit to the Holders of such class of Notes, in accordance with the Board Resolutions authorizing the Redemption, an amount equal to Redemption Price plus Premium, if any; and

(iv) make such other distributions and payments as shall be authorized and directed by the Board Resolutions and indenture supplements executed in connection with .

Section 3.08 B&W Payment/Amgen Payment. The Servicer, any Noteholder, B&W or Amgen may inform the Trustee in writing of the existence of a B&W Shortfall or of an Amgen Payment made by Amgen. If the Trustee receives written notice from any Person other than the Servicer that there is a B&W Shortfall or an Amgen Payment made by Amgen, the Trustee shall promptly notify the Servicer, and the Servicer shall confirm the amount of B&W Shortfall or Amgen Payment. If, as of any Calculation Date, the B&W Shortfall has not been cured by the payment of the B&W Shortfall to B&W, the Trustee shall make a B&W Payment to B&W on the related Payment Date in the amount of such shortfall, provided that, if the Trustee has not received written notice, at least two Business Days prior to any Payment Date, of the existence and amount of a B&W Shortfall, no B&W Payment shall be made. If amounts described in clause (v) of the definition of “Collections” are received after such Calculation Date, they shall be deposited in the Collection Account and included in the Available Collections Amount on the next succeeding Calculation Date.

Section 3.09 Redemptions. (a) Optional Redemption. Subject to the provisions of Section 3.10 hereof, on any Payment Date the Issuer may elect to redeem any class of Notes (i) in whole but not in part out of the

proceeds of the Refinancing Notes, in the case of a Refinancing of such class of Notes, or out of amounts available in the Redemption Account for such purpose, if any, including the proceeds of any Class B Notes but excluding Available Revenues, in each case, at the Redemption Price plus the Redemption Premium, if any, plus accrued and unpaid interest through the Redemption Date (any such redemption, an “Optional Redemption”). The Issuer shall give notice of any such Optional Redemption to the Trustee not later than seven (7) Business Days prior to the date on which notice is to be given in accordance with Section 3.10(a). Such notice to the Trustee shall include a copy of the Board Resolution authorizing such Optional Redemption and shall set forth the relevant information regarding such Optional Redemption, including the information to be included in the notice given pursuant to Section 3.10(a).

(b) Cash Sweep Principal Redemption. By March 15 of each year, or, if later, within three Business Days after the date on which the Servicer provides the Trustee with the information necessary to calculate the Cash Sweep Principal Amount and the Cash Sweep Premium, commencing in 2006, the Trustee shall distribute a notice to the holders of Class A Notes that sets forth the amount of the Cash Sweep Principal Amount and the Cash Sweep Premium, if any, to be paid in redemption of the Class A Notes on the following March 30 Payment Date. The Cash Sweep Principal Amount and the Cash Sweep Premium, if any, shall be allocated pro rata proportionately to the principal amount of the Class A Notes. If mailed in the manner herein provided, the notice shall be conclusively presumed to have been given whether or not the Holder receives such notice. Failure to give notice or any defect in the notice shall not affect the validity of the notice.

(c) Other Redemptions. A supplemental indenture providing for the issuance of any Refinancing Notes or Class B Notes may authorize one or more redemptions, in whole or in part, of such Notes, on such terms and subject to such conditions as shall be specified in such supplemental indenture.

Section 3.10 Procedure for Redemptions. (a) Method of Redemption. The Trustee (or the Servicer acting as its agent (or any authorized agent of the Servicer)) shall give written notice in respect of any Redemption of any class of Notes under Section 3.9 hereof to each Holder of such Notes at least thirty (30) days but not more than sixty (60) days before such Redemption Date. The Trustee shall not be permitted to deliver any notice under this Section 3.10(a) unless and until it shall have received evidence satisfactory to it that amounts sufficient to pay (A) the Redemption Price for such class of Notes plus the Redemption Premium, if any, (B) all accrued and unpaid interest, including Additional Interest, in respect of each class of Notes ranking pari passu therewith or prior thereto and (C) the Transaction Expenses relating to such Redemption are deposited, or will be deposited on or before the Redemption Date, in the Redemption Account established in respect of such Redemption. Each notice in respect of a Redemption given pursuant to this Section 3.10(a) shall state (i) the applicable Redemption Date, (ii) the Trustee’s arrangements for making payments in respect of such Redemption, (iii) the Redemption Price of the Notes to be redeemed and the Redemption Premium, if any, (iv) in the case of a Redemption of the Notes of any class in part, the portion of the Outstanding Principal Balance of the Notes that will be redeemed; (v) that Notes to be redeemed in a Redemption in whole must be surrendered (which action may be taken by any Holder of the Notes or its authorized agent) to the Trustee to collect the Redemption Price on such Notes, and (vi) that, unless the Issuer defaults in the payment of the Redemption Price, interest on Notes called for Redemption in whole shall cease to accrue on and after the Redemption Date. If mailed in the manner herein provided, the notice shall be conclusively presumed to have been given whether or not the Holder receives such notice. Failure to give notice or any defect in the notice shall not affect the validity of the notice.

(b) Deposit of Redemption Amount. On or before any Redemption Date in respect of a Redemption under Section 3.9, the Issuer shall, to the extent an amount equal to the Redemption Price of the Notes to be redeemed and any Transaction Expenses as of the Redemption Date is not then held by the Issuer or on deposit in the Redemption Account, deposit or cause to be deposited in the Redemption Account an amount in immediately available funds equal to such amount.

(c) Notes Payable on Redemption Date. After notice has been given under Section 3.10(a) hereof as to the Redemption Date in respect of any Redemption, the Outstanding Principal Balance of the Notes to be redeemed on such Redemption Date shall become due and payable at the Corporate Trust Office of the Trustee, and from and after such Redemption Date (unless there shall be a default by the Issuer in the payment of the Redemption Price) such principal amount shall cease to bear interest. Upon surrender of any Note for redemption in accordance with such notice, the Redemption Price of such Note shall be paid as provided for in Section 3.07(b). If any Note to be redeemed shall not be so paid upon surrender thereof for redemption, the Outstanding Principal Balance thereof shall continue to bear interest from the Redemption Date until paid at the interest rate applicable to such Note.

Section 4.01 Events of Default. Each of the following events shall constitute an “Event of Default” hereunder with respect to any class of Notes, and each such Event of Default shall be deemed to exist and continue so long as, but only so long as, it shall not have been waived or remedied, as applicable:

(a) (i) in the case of the Class A Notes, failure to pay the interest on the Class A Notes due on any Payment Date other than the Final Maturity Date in full on such Payment Date or by the next succeeding Payment Date, together with Additional Interest on any interest not paid on the Payment Date on which it was originally due, (ii) failure to pay in full on the Final Maturity Date all accrued and unpaid interest due on the Class A Notes, and (iii) in the case of any class of Notes other than the Class A Notes, failure to pay when due interest on any Notes of such class on any Payment Date;

(b) failure to pay when due principal and Premium, if any, on any Notes of such class on or prior to the applicable Final Maturity Date or to pay the Redemption Price and the Redemption Premium, if any, when due on any Redemption Date or Refinancing Date for such class;

(c) failure to pay any amount (other than interest, Premium and principal on the Notes) when due and payable in connection with such class of Notes and the continuance of such default for a period of five Business Days or more after written notice thereof is given to the Issuer by the Trustee;

(d) failure by the Issuer to comply with any of the covenants, obligations, conditions or provisions binding on it under this Indenture or the Notes (other than a payment default for which provision is made in clause (a), (b) or (c) of this Section 4.01), if such failure materially adversely affects the Holders of such class of Notes and continues for a period of 30 days or more after written notice thereof has been given to the Issuer by the Trustee, upon the written direction of Holders (not affiliated with the Issuer) of a majority of the aggregate Outstanding Principal Balance of the Notes);

(e) a court having jurisdiction in the premises enters a decree or order for (i) relief in respect of the Issuer under any Applicable Law relating to bankruptcy, insolvency, receivership, winding-up, liquidation, reorganization, examination, relief of debtors or other similar law now or hereafter in effect; (ii) appointment of a receiver, liquidator, examiner, assignee, custodian, trustee, sequestrator or similar official of the Issuer; or (iii) the winding up or liquidation of the affairs of the Issuer and, in each case, such decree or order shall remain unstayed or such writ or other process shall not have been stayed or dismissed within 90 days from entry thereof;

(f) the Issuer (i) commences a voluntary case under any Applicable Law relating to bankruptcy, insolvency, receivership, winding-up, liquidation, reorganization, examination, relief of debtors or other similar law now or hereafter in effect, or consents to the entry of an order for relief in any involuntary case under any such law; (ii) consents to the appointment of or taking possession by a receiver, liquidator, examiner, assignee, custodian, trustee, sequestrator or similar official of the Issuer or for all or substantially all of the property and assets of the Issuer; or (iii) effects any general assignment for the benefit of creditors;

(g) any judgment or order for the payment of money in excess of $1,000,000 shall be rendered against the Issuer and either (i) enforcement proceedings have been commenced by any creditor upon such judgment or order or (ii) there is any period of 10 consecutive days during which a stay of enforcement of such judgment or order, by reason of a pending appeal or otherwise, shall not be in effect;

(h) the organizational documents creating the Issuer cease to be in full force and effect without replacement documents having the same terms being in full force and effect; or

(i) NPS shall have failed to perform in any material respect any of its covenants under Sections 2.2(a) and (b), 6.1(b), (c) and (h) and 6.2(a), (c) and (d) of the Purchase and Sale Agreement.

Section 4.02 Acceleration, Rescission and Annulment. (a) If an Event of Default with respect to the Notes (other than an Event of Default under clause (e) or (f) of Section 4.01) occurs and is continuing, the Trustee may, and, upon the direction of Holders (not affiliated with the Issuer) of a majority of the aggregate Outstanding Principal Balance of the Senior Class of Notes, shall, give an Acceleration Notice to the Issuer declaring the

Outstanding Principal Balance of such Notes and all accrued and unpaid interest thereon to be due and payable. Upon delivery of an Acceleration Notice, such Outstanding Principal Balance and all accrued and unpaid interest thereon shall be due and payable. At any time after the Trustee has declared the Outstanding Principal Balance of the Notes to be due and payable and prior to the exercise of any other remedies pursuant to this Article IV, the Trustee, upon the direction of Holders (not affiliated with the Issuer) of a majority of the aggregate Outstanding Principal Balance of the Senior Class of Notes, shall, subject to Section 4.05(a), by written notice to the Issuer and the Trustee, rescind and annul such declaration and thereby annul its consequences if: (i) there has been paid to or deposited with the Trustee an amount sufficient to pay all overdue installments of interest on the Notes, and the principal of, and Premium, if any, on the Notes that would have become due otherwise than by such declaration of acceleration, (ii) the rescission would not conflict with any judgment or decree and (iii) all other Defaults and Events of Default, other than nonpayment of interest and principal on the Notes that have become due solely because of such acceleration have been cured or waived. If an Event of Default under clause (e) or (f) of Section 4.01 occurs, the Outstanding Principal Balance of the Notes and all accrued and unpaid interest thereon shall automatically become due and payable without any further action by any party.

(b) Notwithstanding Sections 4.02, 4.03 and 4.12 hereof, after the occurrence and during the continuation of an Event of Default, no Holders of any class of Notes other than the Senior Class of Notes shall be permitted to give or direct the giving of an Acceleration Notice, or to exercise any remedy in respect of such Event of Default, and no Person other than the Controlling Party, at the direction of a majority of the aggregate Outstanding Principal Balance of the Senior Class of Notes, may give an Acceleration Notice or exercise any such remedy.

(c) Within 30 days after the occurrence of an Event of Default in respect of any class of Notes, the Trustee shall give to the Noteholders of such class of Notes notice, transmitted by mail, of all uncured or unwaived Defaults known to it on such date; provided that the Trustee may withhold such notice with respect to a Default (other than a payment default with respect to interest, principal or Premium, if any) if it determines in good faith that withholding such notice is in the interest of the affected Noteholders.

Section 4.03 Other Remedies. Upon the delivery of an Acceleration Notice in accordance with Section 4.02 hereof or if any Acceleration Default shall have occurred and be continuing, the Senior Trustee may pursue any available remedy by proceeding at law or in equity to collect the payment of principal of, Premium, if any, or interest on the Notes or to enforce the performance of any provision of the Notes, this Indenture or the Pledge Agreement, including any of the following:

(a) The Senior Trustee may obtain the appointment of a Receiver of the Indenture Estate as provided in Section 12.08 hereof and the Issuer consents to and waives any right to notice of such appointment.

(b) The Senior Trustee may, without notice to the Issuer and at such time as the Senior Trustee in its sole discretion may determine, exercise any or all of the Issuer’s rights in, to and under or in any way connected with or related to, any or all of the Indenture Estate, including, (A) demanding and enforcing payment and performance of, and exercising any or all of the Issuer’s rights and remedies with respect to the collection, enforcement or prosecution of, any or all of the Royalty Rights and under the Related Documents, in each case by legal proceedings or otherwise, (B) settling, adjusting, compromising, extending, renewing, discharging and releasing any or all of, and any legal proceedings brought to collect or enforce any or all of, the Royalty Rights and under the Related Documents, and (C) preparing, filing and signing the name of the Issuer on (1) any proof of claim or similar document to be filed in any bankruptcy or similar proceeding involving the Royalty Rights and the Related Documents and (2) any notice of lien, assignment or satisfaction of lien, or similar document in connection with the Royalty Rights and the Related Documents.

(c) The Senior Trustee may, without notice except as specified below, sell or cause the sale of all or any part of the Indenture Estate in one or more parcels at public or private sale, at any of the Senior Trustee’s offices or elsewhere, for cash, on credit or for future delivery, and upon such other terms as the Senior Trustee may deem commercially reasonable, provided that, so long as the License Agreement has not been terminated, the Senior Trustee shall make any such sale only to a Person that is a Permitted Holder. The Issuer agrees that, to the extent notice of sale shall be required by law, at least ten (10) days’ notice to the Issuer of the time and place of any public sale or the time after which any private sale is to be made shall constitute reasonable notification. The Senior Trustee shall not be obligated to make any sale of all or any part of the Indenture Estate regardless of notice of sale having been given. The Senior Trustee may adjourn any public or private sale from time to time by announcement at the time and place fixed therefor, and such sale may, without further notice, be made at the time and place to which it was so adjourned.

(d) The Senior Trustee may, instead of exercising the power of sale conferred upon it by Section 4.03(c) and Applicable Law, may proceed by a suit or suits at law or in equity to foreclose the Security Interest and sell all or any portion of the Indenture Estate under a judgment or a decree of a court or courts of competent jurisdiction, provided that, so long as the License Agreement has not been terminated, the Senior Trustee shall make any such foreclosure sale only to a Person that is a Permitted Holder.

(e) The Senior Trustee may require the Issuer to, and the Issuer hereby agrees that it shall at its expense and upon request of the Senior Trustee forthwith assemble all or part of the Indenture Estate as directed by the Senior Trustee and make it available to the Senior Trustee at a place to be designated by the Senior Trustee that is reasonably convenient to both parties.

(f) In addition to the rights and remedies provided for in this Indenture, the Senior Trustee may exercise in respect of the Indenture Estate all the rights and remedies of a secured party upon default under the UCC (whether or not the UCC applies to the affected property included in the Indenture Estate) and under all other Applicable Law, provided that, so long as the License Agreement has not been terminated, the Senior Trustee shall cause any sale of the Collateral to be made only to a Person that is a Permitted Holder.

(g) The Senior Trustee may maintain a proceeding even if it does not possess any of the Notes or does not produce any of them in the proceeding.

Section 4.04 Limitation on Suits. Without limiting the provisions of Section 4.09 and the final sentence of Section 12.04, no Holder shall have any right to institute any proceeding, judicial or otherwise, with respect to this Indenture, the Pledge Agreement or the Notes, or for the appointment of a receiver or trustee, or for any other remedy hereunder, unless:

(a) such Holder is a holder of the Senior Class of Notes and has previously given written notice to the Trustee of a continuing Event of Default;

(b) the Holders (not affiliated with the Issuer) of a majority of the aggregate Outstanding Principal Balance of the Senior Class of Notes make a written request to the Trustee to pursue a remedy hereunder;

(c) such Holder or Holders offer to the Trustee an indemnity reasonably satisfactory to the Trustee against any costs, expenses and liabilities to be incurred in complying with such request;

(d) the Trustee does not comply with such request within 60 days after receipt of the request and the offer of indemnity; and

(e) during such 60-day period, Holders of a majority of the Outstanding Principal Balance of the Senior Class of Notes do not give the Trustee a direction inconsistent with such request.

No one or more Noteholders may use this Indenture to affect, disturb or prejudice the rights of another Holder or to obtain or seek to obtain any preference or priority not otherwise created by this Indenture and the terms of the Notes over any other Holder or to enforce any right under this Indenture, except in the manner herein provided.

Section 4.05 Waiver of Existing Defaults. (a) The Trustee or the Holders of a majority of the aggregate Outstanding Principal Balance of the Senior Class of Notes by notice to the Trustee may waive any existing Default (or Event of Default) hereunder and its consequences, except a Default (or Event of Default): (i) in the payment of the interest on, principal of, and Premium, if any, on any Note or (ii) in respect of a covenant or provision hereof which under Article IX hereof cannot be modified or amended without the consent of the Holder of each Note affected thereby. Upon any such waiver, such Default shall cease to exist, and any Event of Default arising therefrom shall be deemed to have been cured for every purpose of this Indenture, but no such waiver shall extend to any subsequent or other Default (or Event of Default) or impair any right consequent thereon.

(b) Any written waiver of a Default or an Event of Default given by Holders of the Notes to the Trustee and the Issuer in accordance with the terms of this Indenture shall be binding upon the Trustee and the other parties hereto. Unless such writing expressly provides to the contrary, any waiver so granted shall extend only to the specific event or occurrence which gave rise to the Default or Event of Default so waived and not to any other similar event or occurrence which occurs subsequent to the date of such waiver.

Section 4.06 Restoration of Rights and Remedies. If the Trustee or any Noteholder of the Senior Class of Notes has instituted any proceeding to enforce any right or remedy under this Indenture, and such proceeding has been discontinued or abandoned for any reason, or has been determined adversely to the Trustee or such Holder, then in every such case the Issuer, the Trustee and the Noteholders shall, subject to any determination in such proceeding, be restored severally and respectively to their former positions hereunder, and thereafter all rights and remedies of the Trustee and the Noteholders shall continue as though no such proceeding has been instituted.

Section 4.07 Remedies Cumulative. Each and every right, power and remedy herein given to the Trustee specifically or otherwise in this Indenture shall be cumulative and shall be in addition to every other right, power and remedy herein specifically given or now or hereafter existing at law, in equity or by statute, and each and every right, power and remedy whether specifically herein given or otherwise existing may be exercised from time to time and as often and in such order as may be deemed expedient by the Trustee, and the exercise or the beginning of the exercise of any power or remedy shall not be construed to be a waiver of the right to exercise at the same time or thereafter any other right, power or remedy. No delay or omission by the Trustee in the exercise of any right, remedy or power or in the pursuance of any remedy shall impair any such right, power or remedy or be construed to be a waiver of any Default on the part of the Issuer or to be an acquiescence.

Section 4.08 Authority of Courts Not Required. The parties hereto agree that, to the greatest extent permitted by law, the Trustee shall not be obliged or required to seek or obtain the authority of, or any judgment or order of, the courts of any jurisdiction in order to exercise any of its rights, powers and remedies under this Indenture, and the parties hereby waive any such requirement to the greatest extent permitted by law.

Section 4.09 Rights of Noteholders to Receive Payment. Notwithstanding any other provision of this Indenture, the right of any Noteholder to receive payment of interest on, principal of, or Premium, if any, on its Note on or after the respective due dates therefor expressed in such Note, or to bring suit for the enforcement of any such payment on or after such respective dates, shall not be impaired or affected without the consent of such Noteholder.

Section 4.10 Trustee May File Proofs of Claim. The Trustee may file such proofs of claim and other papers or documents as may be necessary or advisable in order to have the claims of the Trustee and of any Noteholder allowed in any judicial proceedings relating to any obligor on the Notes, its creditors or its property.

Section 4.11 Undertaking for Costs. All parties to this Indenture agree, and each Noteholder by its acceptance thereof shall be deemed to have agreed, that in any suit for the enforcement of any right or remedy under this Indenture or in any suit against the Trustee for any action taken or omitted by it as Trustee, a court in its discretion may require the filing by any party litigant in such suit of an undertaking to pay the costs of such suit, and the court in its discretion may assess reasonable costs, including reasonable attorneys’ fees, against any party litigant in such suit, having due regard to the merits and good faith of the claims or defense made by the party litigant. This Section 4.11 does not apply to a suit instituted by the Trustee, a suit instituted by any Noteholder for the enforcement of the payment of interest, principal, or Premium, if any, on his Note on or after the respective due dates expressed in such Note, or a suit by a Noteholder or Noteholders of more than 10% of the Outstanding Principal Balance of the Notes.

Section 4.12 Control by Noteholders. Subject to Sections 4.02 and 4.04 hereof and to the rights of the Trustee hereunder, Noteholders of any class of Notes with at least a majority of the Outstanding Principal Balance of such class of Notes shall have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee under this Indenture; provided that:

(1) such direction shall not be in conflict with any rule of law or with this Indenture and would not involve the Trustee in personal liability or expense;

(2) the Trustee shall not determine that the action so directed would be unjustly prejudicial to the Noteholders of such class not taking part in such direction; and

(3) the Trustee may take any other action deemed proper by the Trustee which is not inconsistent with such direction.

Section 4.13 Controlling Party. The “Controlling Party” with respect to this Indenture shall be the Senior Trustee, which shall be (A) so long as any Class A Notes are outstanding, the Trustee acting at the direction of the Noteholders of the Class A Notes evidencing a majority of the Outstanding Principal Balance of the Class A Notes, and (B) after the Class A Notes have been repaid in full, and so long as any Class B Notes are Outstanding, the Trustee acting at the direction of the Noteholders of the Class B Notes evidencing a majority of the Outstanding Principal Balance of the Class B Notes. For purposes of giving effect to the foregoing, the Trustee irrevocably agrees (and the Noteholders (other than the Noteholders represented by the Controlling Party) shall be deemed to agree by virtue of their purchase of the Notes) that the Controlling Party, as determined in accordance with this Section 4.13, shall have all of the rights granted to it under this Indenture, including the right to direct the Trustee to take certain action as provided for in this Indenture, and the Trustee hereby agrees to act in accordance with each such authorized direction of the Controlling Party.

Section 4.14 Application of Proceeds. All cash proceeds received by the Senior Trustee in respect of any sale of, collection from, or other realization upon all or any part of the Indenture Estate shall be deposited in the Collection Account and distributed as provided in Article III. Any surplus of such cash proceeds held by the Senior Trustee and remaining after payment in full of all the Secured Obligations shall be paid over to the Issuer or whomsoever may be lawfully entitled to receive such surplus as provided in Section 3.07 hereof. Any amount received for any sale or sales conducted in accordance with the terms of Section 4.03 shall to the extent permitted by Applicable Law be deemed conclusive and binding on the Issuer and the Noteholders.

Section 4.15 Waivers of Rights Inhibiting Enforcement. The Issuer waives (a) any claim that, as to any part of the Indenture Estate, a public sale, should the Senior Trustee elect so to proceed, is, in and of itself, not a commercially reasonable method of sale for such part of the Indenture Estate, (b) the right to assert in any action or proceeding between it and the Senior Trustee offsets or counterclaims that it may have, (c) except as otherwise provided in any of the Related Documents, TO THE EXTENT PERMITTED BY APPLICABLE LAW, NOTICE OR JUDICIAL HEARING IN CONNECTION WITH THE TRUSTEE’S TAKING POSSESSION OR DISPOSITION OF ANY OF THE INDENTURE ESTATE INCLUDING ANY AND ALL PRIOR NOTICE AND HEARING FOR ANY PREJUDGMENT REMEDY OR REMEDIES AND ANY SUCH RIGHT THAT THE ISSUER WOULD OTHERWISE HAVE UNDER THE CONSTITUTION OR ANY STATUTE OF THE U.S. OR OF ANY STATE, AND ALL OTHER REQUIREMENTS AS TO THE TIME, PLACE AND TERMS OF SALE OR OTHER REQUIREMENTS WITH RESPECT TO THE ENFORCEMENT OF THE TRUSTEE’S RIGHTS HEREUNDER, (d) all rights of redemption, appraisement, valuation, stay and extension or moratorium and (e) all other rights the exercise of which would, directly or indirectly, prevent, delay or inhibit the enforcement of any of the rights or remedies under this Indenture or the absolute sale of the Indenture Estate, now or hereafter in force under any Applicable Law, and the Issuer, for itself and all who may claim under it, insofar as it or they now or hereafter lawfully may, hereby waive the benefit of all such laws and rights.

Section 5.01 Representations and Warranties. The Issuer represents and warrants to the Trustee as of the Closing Date as follows:

(a) Due Organization. The Issuer is a limited liability company created under the laws of Delaware, with full power and authority to conduct its business; and the Issuer is not in liquidation or bankruptcy and has not taken any of the actions described in Section 4.01(f).

(b) Special Purpose Status. The Issuer has not engaged in any activities since its organization (other than those incidental to its organization and permitted by its organizational documents, the execution of the Related Documents to which it is a party and the activities referred to, in or contemplated by such agreements), and the Issuer has not paid any dividends or made any similar distributions since its organization.

(c) Non-Contravention. The creation of the Notes and the issuance, execution and delivery of, and the compliance by the Issuer with the terms of the Notes and each of the other Related Documents to which it is a party:

(i) do not at the Closing Date conflict with, or result in a breach of any of the terms or provisions of, or constitute a default under, the organizational documents of the Issuer or with any existing law, rule or regulation applying to or affecting the Issuer or any judgment, order or decree of any government, governmental body or court having jurisdiction over the Issuer; and

(ii) do not at the Closing Date violate, or constitute a default under, any deed, indenture, agreement or other instrument or obligation to which the Issuer is a party or by which it or any part of its assets, property or revenues are bound.

(d) Due Authorization. The creation, execution and issuance of the Notes, the execution and delivery by the Issuer of the Related Documents executed by it and the performance by it of its obligations hereunder and thereunder and the arrangements contemplated hereby and thereby to be performed by it have been duly authorized by it.

(e) Validity and Enforceability. This Indenture constitutes, and the Related Documents to which it is a party, when executed and delivered and, in the case of the Notes, when issued and authenticated, will constitute valid, legally binding and (subject to general equitable principles, and laws relating to insolvency, liquidation, reorganization and other laws of general application relating to creditors’ rights or claims or to laws of prescription or the concepts of materiality, reasonableness, good faith and fair dealing) enforceable obligations of the Issuer.

(f) No Defaults. On the Closing Date, there exists no Event of Default nor any event which, had the Notes already been issued, would constitute a Default or an Event of Default.

(g) No Encumbrances. On the Closing Date, subject to the Security Interests created in favor of the Trustee and except for Permitted Encumbrances, there exists no Encumbrance over the assets of the Issuer which ranks prior to or pari passu with the obligation to make payments on the Notes.

(h) No Consents. All consents, approvals, authorizations or other orders of all regulatory authorities required (excluding any required by the other parties to the Related Documents) for or in connection with the execution and performance of the Related Documents by the Issuer and the issuance and performance of the Notes and the offering of the Notes by the Issuer have been obtained and are in full force and effect and are not contingent upon fulfillment of any condition.

(i) No Litigation. There is no action, suit, investigation or proceeding pending against, or to the knowledge of the Issuer, threatened against, the Issuer before any court or arbitrator or any governmental body, agency or official which in any manner challenges or seeks to prevent, enjoin, alter or materially delay the transactions contemplated by this Indenture (including the Exhibits and Schedules attached hereto) and the Related Documents to which the Issuer is a party.

(k) Ownership. The Issuer is the beneficial owner of the Royalty Rights, free and clear of any Encumbrances other than Permitted Encumbrances.

(l) No Filings. Under the laws of Delaware and New York (including U.S. federal law) in force at the date hereof, it is not necessary or desirable that this Indenture or any Related Document (other than evidences and perfection of the Security Interests) be filed, recorded or enrolled by the Issuer with any court or other governmental authority in any such jurisdictions or that any stamp, registration or similar tax be paid by the Issuer on or in relation to this Indenture or any of the other Related Documents (other than (i) the filing of the Indenture and any of the Related Documents with the Securities and Exchange Commission by NPS in order to comply with its obligations under federal securities laws and (ii) filings of Uniform Commercial Code financing statements and the various consents and agreements, if any, pursuant hereto).

(m) Other Representations. The representations and warranties made by the Issuer in any of the other Related Documents to which it is a party are true and accurate as of the date made.

Section 5.02 Covenants. The Issuer covenants with the Trustee that, so long as any Notes are Outstanding, it will perform each of the following covenants and not engage in any activity prohibited by this Indenture without the prior written consent of the Trustee (acting at the direction of the holders of Notes representing a majority in principal amount of the Notes) authorizing the Issuer not to perform any such covenants or to engage in any such activity prohibited by this Indenture, in each case on such terms and conditions, if any, as shall be specified in such prior written consent:

(a) No Release of Obligations. Except as expressly permitted by this Indenture, the Issuer shall not take any action, whether orally or in writing, which would amend, modify, supplement, restate, cancel or terminate or discharge or prejudice the validity or effectiveness of this Indenture, the Pledge Agreement or the Purchase and Sale Agreement, or permit any party to any such document to be released from such obligations.

(b) Limitation on Restricted Payments. The Issuer shall not, directly or indirectly, (i) declare or pay any dividend or make any distribution on its Stock, whether in cash, property, securities or a combination thereof, to NPS or any owner of a beneficial interest in the Issuer or otherwise with respect to any ownership of its Stock; (ii) purchase, redeem, retire or otherwise acquire for value any shares of Stock of the Issuer; (iii) make any payment of principal, interest or Premium, if any, on the Notes or make any voluntary or optional repurchase, defeasance or other acquisition or retirement for value of Indebtedness of the Issuer other than in accordance with the Notes and this Indenture; or (iv) make any investments (other than Eligible Investments and investments permitted under Section 5.02(f) hereof). The term “investment” for purposes of the above restriction shall mean any loan or advance to a Person, any purchase or other acquisition of any beneficial interest, capital stock, warrants, rights, options, obligations or other securities of such Person, any capital contribution to such Person or any other investment in such Person.

(c) Encumbrances. The Issuer shall not (and shall not consent to NPS taking any action that would) create, incur, assume or suffer to exist any Encumbrance over or with respect to any of the Issuer’s assets, other than (i) any Permitted Encumbrance, or (ii) any security interest created or required to be created hereunder, including in connection with the issuance of any Refinancing Notes and Class B Notes.

(d) Limitation on Indebtedness. The Issuer shall not incur, create, issue, assume, guarantee or otherwise become liable for or with respect to, or become responsible for, the payment of, contingently or otherwise, whether present or future (in any such case, to “incur”), Indebtedness, provided, however, that the Issuer may incur Indebtedness in respect of the Class A Notes issued on the Closing Date and of any Class B Notes and Refinancing Notes issued in accordance with this Indenture.

(e) Limitation on Consolidation, Merger and Transfer of Assets. The Issuer shall not consolidate with, merge with or into, or sell, convey, transfer, lease or otherwise dispose of the Royalty Rights or all or any material portion of its other property and assets to, any other Person, or permit any other Person to merge with or into the Issuer.

(f) Limitation on the Issuance, Delivery and Sale of Capital Stock. The Issuer shall not, directly or indirectly, issue, deliver or sell, or consent to issue, deliver or sell any actual, contingent, future or executory membership interests, limited liability company interests, beneficial interests or other equity or ownership interests (however designated, whether voting or non-voting), except for the pledge of its Stock by NPS to the Trustee for the benefit of the Noteholders pursuant to the Pledge Agreement and except for any additional Stock issued to NPS, provided that such Stock is pledged to the Trustee pursuant to the Pledge Agreement and provided further that the Issuer shall not accept any capital contributions from NPS after the Closing Date except for contributions of funds deposited into the Capital Account, which may be used only as provided in Section 3.01(h).

(g) Limitation on Engaging in Business Activities. Except as otherwise provided in the LLC Operating Agreement, the Issuer shall not engage in any business or activity other than purchasing, holding and pledging the Royalty Rights, collecting the Royalty Payments, issuing the Notes, and entering into the Hedge Agreement and the other activities described or referred to in the Private Placement Memorandum, including the acquisition and exploitation of the Licensed Technology, if applicable.

(h) Limitation on Transactions with Affiliates. The Issuer shall not, directly or indirectly, enter into, renew or extend any transaction (including, without limitation, the purchase, sale, lease or exchange of property or assets, or the rendering of any service) with any Affiliate of the Issuer, except upon fair and reasonable terms no less favorable to the Issuer than could be obtained, at the time of such transaction or at the time of the execution of the agreement providing therefor, in a comparable arm’s-length transaction with a Person that is not such an Affiliate.

(i) Bankruptcy and Insolvency; Corporate Governance. The Issuer shall promptly provide the Trustee with written notice of the institution of any proceeding by or against the Issuer seeking to adjudicate it a bankrupt or insolvent, or seeking liquidation, winding up, reorganization, arrangement, adjustment, protection, relief or composition of its debts under any law relating to bankruptcy, insolvency or reorganization or relief of debtors, or seeking the entry of an order for relief or the appointment of a receiver, trustee or other similar official for it or for any substantial part of its property. The Issuer shall not take any action to waive, repeal, amend, vary, supplement or otherwise modify its organizational documents in a manner that would adversely affect the rights, privileges or preferences of any Holder of the Notes, as determined by the Trustee. The Issuer shall not, without an affirmative written Board Resolution of all of the Managers of the Issuer, including the Independent Manager, take any action to waive, repeal, amend, vary, supplement or otherwise modify any provision of the LLC Operating Agreement that requires unanimous written consent of the Board.

(j) Payment of Principal, Premium, if any, and Interest. The Issuer shall duly and punctually pay the principal, Premium, if any, and interest on the Notes in accordance with the terms of this Indenture and the Notes; provided, that the Issuer shall be in compliance with this covenant if it pays in full by the next succeeding Payment Date any interest on the Class A Notes that became due and was not paid on any Payment Date (including Additional Interest thereon).

(k) Limitation on Employees. The Issuer shall not employ any employees other than as required by any provisions of local law or as contemplated by the LLC Operating Agreement; provided that the members, Managers and Service Providers shall not be deemed to be employees for purposes of this Section 5.02(k).

Section 5.03 Reports by the Issuer. (a) The Issuer shall furnish to the Trustee, within 120 days after the end of each fiscal year, a brief certificate from the principal executive officer, principal accounting officer or principal financial officer of the Servicer, as applicable, as to his or her knowledge of the Issuer’s compliance with all conditions and covenants under this Indenture (it being understood that for purposes of this Section 5.03, such compliance shall be determined without regard to any period of grace or requirement of notice provided under this Indenture but shall reflect any interest paid on the Class A Notes by the next succeeding Payment Date as contemplated by the proviso to Section 5.02(j)).

(b) The Issuer shall deliver notice to the Trustee of the occurrence of (i) any Default or Event of Default under this Indenture and (ii) any of the events described in Section 6.4(d) of the Purchase and Sale Agreement promptly and in any event within five (5) Business Days of a Manager of the Issuer becoming aware of such Default, Event of Default, event or situation.

(c) The Issuer shall deliver to the Trustee copies of all materials that the Issuer receives from NPS pursuant to Section 6.4(a), (b) and (c) of the Purchase and Sale Agreement promptly and in any event within five (5) Business Days of the receipt of such materials.

Section 6.01 Acceptance of Trusts and Duties. Except during the continuance of an Event of Default, the Trustee undertakes to perform such duties and only such duties as are specifically set forth in the Indenture, and no implied covenants or obligations shall be read into this Indenture against the Trustee. The duties and responsibilities of the Trustee shall be as provided by the Trust Indenture Act and as set forth herein. The Trustee accepts the trusts hereby created and applicable to it and agrees to perform the same but only upon the terms of this Indenture and the Trust Indenture Act and agrees to receive and disburse all moneys received by it in accordance

with the terms hereof. The Trustee, in its individual capacity and as Trustee, acknowledges and agrees that the Confidential Information includes confidential information of Amgen and is subject to the confidentiality provisions of this Indenture, including the limitations on transfers of the Notes and Beneficial Interests and on sales of the Collateral, and that Amgen is an express third party beneficiary of such confidentiality provisions. The Trustee in its individual capacity shall not be answerable or accountable under any circumstances, except for its own willful misconduct or negligence or breach of any of its representations or warranties set forth herein and the Trustee shall not be liable for any action or inaction of the Issuer or any other parties to any of the Related Documents. Any amounts received by or due to the Trustee under this Indenture, including, without limitation, the fees and out-of-pocket expenses of the Trustee shall be Expenses of the Issuer.

Section 6.02 Absence of Duties. The Trustee, upon written request, shall furnish to any Noteholder, promptly upon receipt thereof, duplicates or copies of all reports, Notices, requests, demands, certificates, financial statements and other instruments furnished to the Trustee under this Indenture.

Section 6.03 Representations or Warranties. The Trustee does not make and shall not be deemed to have made any representation or warranty as to the validity, legality or enforceability of this Indenture, the Notes or any other document or instrument or as to the correctness of any statement contained in any thereof, except that the Trustee in its individual capacity hereby represents and warrants (i) that each such specified document to which it is a party has been or will be duly executed and delivered by one of its officers who is and will be duly authorized to execute and deliver such document on its behalf, and (ii) this Indenture is the legal, valid and binding obligation of US Bank, enforceable against US Bank in accordance with its terms, subject to the effect of any applicable bankruptcy, insolvency, reorganization, moratorium or similar law affecting creditors’ rights generally. The Trustee also represents and warrants that it is not in the business of developing, manufacturing or marketing pharmaceutical or diagnostic products and that it is not an Affiliate of any Person who is in such business.

Section 6.04 Reliance; Agents; Advice of Counsel. The Trustee shall incur no liability to anyone acting upon any signature, instrument, notice, resolution, request, consent, order, certificate, report, opinion, bond or other document or paper believed by it to be genuine and believed by it to be signed by the proper party or parties. The Trustee may accept a copy of a resolution of, in the case of the Issuer, a Manager and, in the case of any other party to any Related Document, the governing body of such Person, certified in an accompanying Officer’s Certificate as duly adopted and in full force and effect, as conclusive evidence that such resolution has been duly adopted and that the same is in full force and effect. As to any fact or matter the manner of ascertainment of which is not specifically described herein, the Trustee shall be entitled to receive and may for all purposes hereof conclusively rely on a certificate, signed by an officer of any duly authorized Person, as to such fact or matter, and such certificate shall constitute full protection to the Trustee for any action taken or omitted to be taken by it in good faith in reliance thereon. To the extent not otherwise specifically provided herein, the Trustee shall assume, and shall be fully protected in assuming, that the Issuer is authorized by its constitutional documents to enter into this Indenture and to take all action permitted to be taken by it pursuant to the provisions hereof, and shall not inquire into the authorization of the Issuer with respect thereto. To the extent not otherwise specifically provided herein, the Trustee shall furnish to the Servicer upon written request such information and copies of such documents as the Trustee may have and as are necessary for the Servicer to perform its duties under Articles II and III hereof or otherwise.

The Trustee shall not be liable for any action it takes or omits to take in good faith that it believes to be authorized or within its rights or powers or for any action it takes or omits to take in accordance with the direction of the Holders in accordance with Section 4.12 hereof relating to the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred upon the Trustee, under this Indenture.

The Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or through agents or attorneys or a custodian or nominee, and the Trustee shall not be responsible for any misconduct or negligence on the part of, or for the supervision of, any such agent, attorney, custodian or nominee appointed with due care by it hereunder.

The Trustee may consult with counsel as to any matter relating to this Indenture and any Opinion of Counsel or any advice of such counsel shall be full and complete authorization and protection in respect of any action taken or suffered or omitted by it hereunder in good faith and in accordance with such advice or Opinion of Counsel.

The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture, or to institute, conduct or defend any litigation hereunder or in relation hereto, at the request, order or direction of any of the Holders, pursuant to the provisions of this Indenture, unless such Holders shall have offered to the Trustee security or indemnity reasonably satisfactory to it against the costs, expenses and liabilities which may be incurred therein or thereby.

The Trustee shall not be required to expend or risk its own funds or otherwise incur any financial liability in the performance of any of its duties hereunder, or in the exercise of any of its rights or powers, if there is reasonable ground for believing that the repayment of such funds or adequate indemnity against such risk or liability is not reasonably assured to it, and none of the provisions contained in this Indenture shall in any event require the Trustee to perform, or be responsible or liable for the manner of performance of, any obligations of the Issuer or the Servicer under this Indenture or any of the Related Documents.

The Trustee shall not be liable for any Losses or Taxes (except for Taxes relating to any compensation, fees or commissions of any entity acting in its capacity as Trustee hereunder) or in connection with the selection of Eligible Investments or for any investment losses resulting from Eligible Investments.

When the Trustee incurs expenses or renders services in connection with an Event of Default specified in Section 4.01(e) or 4.01(f) hereof, such expenses (including the fees and expenses of its counsel) and the compensation for such services are intended to constitute expenses of administration under any bankruptcy law or law relating to creditors’ rights generally.

The Trustee shall not be charged with knowledge of an Event of Default unless a Responsible Officer of the Trustee obtains actual knowledge of such event or the Trustee receives written notice of such event from the Issuer, the Servicer or Noteholders owning Notes aggregating not less than 10% of the Outstanding Principal Balance of the Notes.

The Trustee shall have no duty to monitor the performance of the Issuer, the Servicer or any other party to the Related Documents, nor shall it have any liability in connection with the malfeasance or nonfeasance by such parties.

Section 6.05 Not Acting in Individual Capacity. The Trustee acts hereunder solely as trustee unless otherwise expressly provided; and all Persons, other than the Noteholders to the extent expressly provided in this Indenture, having any claim against the Trustee by reason of the transactions contemplated hereby shall look, subject to the lien and priorities of payment as herein provided, only to the property of the Issuer for payment or satisfaction thereof.

Section 6.06 Compensation of Trustee. The Trustee agrees that it shall have no right against the Noteholders or, except as provided in Section 3.07(a) hereof, the property of the Issuer, for any fee as compensation for its services hereunder. The Issuer shall pay to the Trustee from time to time such compensation as is agreed between the two parties. The compensation shall be paid to the Trustee as provided in Sections 3.05(a) and 3.07(a)

Section 6.07 Notice of Defaults. As promptly as practicable after, and in any event within 30 days after, the occurrence of any Default hereunder, the Trustee shall transmit by mail to the Issuer and the Noteholders of the related class in accordance with Section 313(c) of the Trust Indenture Act, notice of such Default hereunder actually known to a Responsible Officer of the Trustee, unless such Default shall have been cured or waived; provided, however, that, except in the case of a Default on the payment of the interest, principal, or Premium, if any, on any Note, the Trustee shall be fully protected in withholding such notice if and so long as a trust committee of Responsible Officers of the Trustee in good faith determines that the withholding of such notice is in the interests of the Noteholders of the related class.

Section 6.08 May Hold Notes. The Trustee, any Paying Agent, the Registrar or any of their Affiliates or any other agent in their respective individual or any other capacity, may become the owner or pledgee of the Notes and, subject to Sections 310(b) and 311 of the Trust Indenture Act, may otherwise deal with the Issuer with the same rights it would have if it were not the Trustee, Paying Agent, Registrar or such other agent.

Section 6.09 Corporate Trustee Required; Eligibility. There shall at all times be an Trustee which shall be eligible to act as a trustee under Section 310(a) of the Trust Indenture Act and shall meet the Eligibility Requirements. If such corporation publishes reports of conditions at least annually, pursuant to law or to the

requirements of any federal, state, territorial or District of Columbia supervising or examining authority, then for the purposes of this Section 6.09, the combined capital and surplus of such corporation shall be deemed to be its combined capital and surplus as set forth in its most recent report of conditions so published.

In case at any time the Trustee shall cease to be eligible in accordance with the provisions of this Section 6.09 to act as Trustee, the Trustee shall resign immediately as Trustee in the manner and with the effect specified in Section 7.01 hereof.

Section 6.10 Reports by the Trustee. Within 60 days after May 15 of each year commencing with the first full year following the issuance of any class of Notes, the Trustee shall, if required by Section 313(a) of the Trust Indenture Act, transmit to the Noteholders of each class, as provided in Section 313(c) of the Trust Indenture Act, a brief report describing, among other things, any changes in eligibility and qualifications of the Trustee and any issuance of Class B Notes.

Section 6.11 Calculation Agent. The Trustee shall act as the Calculation Agent hereunder. Subject to the approval of the Issuer and Noteholders holding a majority of the Outstanding Principal Balance of the Notes, another Person may become the Calculation Agent on such terms as shall be approved by them.

Section 6.12 Pledge Agreement. The Trustee shall enter into the Pledge Agreement with NPS on the Closing Date and shall hold the collateral pledged thereunder as part of the Indenture Estate. The provisions of this Article VI shall apply to the Trustee’s exercise of rights and remedies under the Pledge Agreement, mutatis mutandis.

Section 7.01 Resignation and Removal of Trustee. The Trustee may resign as to all or any of the classes of Notes at any time without cause by giving at least 30 days’ prior written notice to the Issuer, the Servicer and the Holders. Holders of a majority of the Outstanding Principal Balance of any class of Notes may at any time remove the Trustee as to such class without cause, with the consent of the Issuer if no Event of Default shall have occurred and be continuing, by an instrument in writing delivered to the Issuer, the Servicer and the Trustee being removed. In addition, the Issuer may remove the Trustee as to any class of Notes if: (i) such Trustee fails to comply with Section 310 of the Trust Indenture Act after written request therefor by the Issuer or the Noteholders of the related class who have been bona fide Noteholders for at least six months, (ii) such Trustee fails to comply with Section 7.02(d) or any other provision hereof, (iii) such Trustee is adjudged a bankrupt or an insolvent, (iv) a receiver or public officer takes charge of such Trustee or its property or (v) such Trustee becomes incapable of acting. References to the Trustee in this Indenture include any successor Trustee as to all or any of the classes of Notes appointed in accordance with this Article VII. Any resignation or removal of the Trustee pursuant to this Section 7.01 shall not be effective until a successor Trustee shall have been duly appointed and vested as Trustee pursuant to Section 7.02.

Section 7.02 Appointment of Successor. (a) In the case of the resignation or removal of the Trustee as to any class of Notes under Section 7.01 hereof, the Issuer shall promptly appoint a successor Trustee as to such class; provided that the Noteholders holding a majority of the Outstanding Principal Balance of such class of Notes may appoint, within one year after such resignation or removal, a successor Trustee as to such class which may be other than the successor Trustee appointed by the Issuer, and such successor Trustee appointed by the Issuer shall be superseded by the successor Trustee so appointed by the Noteholders. If a successor Trustee as to any class of Notes shall not have been appointed and accepted its appointment hereunder within 60 days after the Trustee gives notice of resignation as to such class, the retiring Trustee, the Issuer, the Servicer or a majority of the Outstanding Principal Balance of such class of Notes may petition any court of competent jurisdiction for the appointment of a successor Trustee as to such class. Any successor Trustee so appointed by such court shall immediately and without further act be superseded by any successor Trustee appointed as provided in the first sentence of this paragraph within one year from the date of the appointment by such court.

(b) Any successor Trustee as to any class of Notes, however appointed, shall execute and deliver to the Issuer, the Servicer and the predecessor Trustee as to such class an instrument accepting such

appointment, and thereupon such successor Trustee, without further act, shall become vested with all the estates, properties, rights, powers, duties and trusts of such predecessor Trustee hereunder in the trusts hereunder applicable to it with like effect as if originally named the Trustee as to such class herein; provided that, upon the written request of such successor Trustee, such predecessor Trustee shall, upon payment of all amounts due and owing to it, execute and deliver an instrument transferring to such successor Trustee, upon the trusts herein expressed applicable to it, all the estates, properties, rights, powers and trusts of such predecessor Trustee, and such predecessor Trustee shall duly assign, transfer, deliver and pay over to such successor Trustee all moneys or other property then held by such predecessor Trustee hereunder solely for the benefit of such class of Notes.

(c) If a successor Trustee is appointed with respect to one or more (but not all) classes of the Notes, the Issuer, the predecessor Trustee and each successor Trustee with respect to each class of Notes shall execute and deliver an indenture supplemental hereto which shall contain such provisions as shall be deemed necessary or desirable to confirm that all the rights, powers, trusts and duties of the predecessor Trustee with respect to the classes of Notes as to which the predecessor Trustee is not retiring shall continue to be vested in the predecessor Trustee, and shall add to or change any of the provisions of this Indenture as shall be necessary to provide for or facilitate the administration of the Notes hereunder by more than one Trustee.

(d) Each Trustee shall be an Eligible Institution and shall meet the Eligibility Requirements, if there be such an institution willing, able and legally qualified to perform the duties of an Trustee hereunder.

(e) Any corporation into which the Trustee may be merged or converted or with which it may be consolidated, or any corporation resulting from any merger, conversion or consolidation to which the Trustee shall be a party, or any corporation to which substantially all the business of the Trustee may be transferred, shall, subject to the terms of paragraph (c) of this Section 7.02, be the Trustee under this Indenture without further act.

Section 8.01 Indemnity. The Issuer shall indemnify the Trustee (and its officers, directors, employees and agents) for, and hold it harmless against, any loss, liability or expense incurred by it without bad faith, gross negligence or willful misconduct on its part in connection with the acceptance or administration of this Indenture and its duties under this Indenture and the Notes, including the costs and expenses of defending itself against any claim or liability and of complying with any process served upon it or any of its officers in connection with the exercise or performance of any of its powers or duties and hold it harmless against, any loss, liability or reasonable expense incurred without bad faith, gross negligence or willful misconduct on its part, arising out of or in connection with actions taken or omitted to be taken in reliance on any Officer’s Certificate furnished hereunder, or the failure to furnish any such Officer’s Certificate required to be furnished hereunder. The Trustee shall notify the Issuer promptly of any claim asserted against the Trustee for which it may seek indemnity; provided, however, that failure to provide such notice shall not invalidate any right to indemnity hereunder. The Issuer shall defend the claim and the Trustee shall cooperate in the defense. The Trustee may have separate counsel and the Issuer shall pay the reasonable fees and expenses of such counsel. The Issuer need not pay for any settlements made without its consent; provided that such consent shall not be unreasonably withheld or delayed. The Issuer need not reimburse any expense or provide any indemnity against any loss, liability or expense incurred by the Trustee through bad faith, gross negligence or willful misconduct.

Section 8.02 Noteholders’ Indemnity. The Trustee shall be entitled, subject to such Trustee’s duty during a Default to act with the required standard of care, to be indemnified by the Noteholders of any class of Notes before proceeding to exercise any right or power under this Indenture at the request or direction of such Holders.

Section 8.03 Survival. The provisions of Sections 8.01 and 8.02 hereof shall survive the termination of this Indenture or the earlier resignation or removal of the Trustee.

Section 9.01 Modification with Consent of Holders. With the consent of Holders of a majority of the Outstanding Principal Balance of the Notes on the date of any vote of such Holders (voting as a single class), the

Issuer, when authorized by a Board Resolution, may amend or modify this Indenture or the Notes; provided that, without the consent of Holders of one hundred percent (100%) of the Outstanding Principal Balance of the class of Notes affected thereby, no such amendment may reduce the percentage of Holders of any such class of Notes required to take or approve any action hereunder; change the amount or the time of payment of any amount owing or payable with respect to any such class of Notes or change the rate or manner of calculation of interest payable with respect to any such class of Notes; alter or modify the provisions with respect to the Collateral for the Notes or the manner of payment or the order of priorities in which payments or distributions hereunder will be made as between the Holders of such Notes and the Issuer; or consent to any assignment of the Issuer’s rights to a party other than the Trustee for the benefit of the Noteholders (each, a “Basic Terms Modification”); provided further, that the Holders of a majority of the Outstanding Principal Balance of the Senior Class of Notes, by written notice to the Trustee, may waive any Default or Event of Default pursuant to Section 4.05 hereof.

It shall not be necessary for the consent of the Holders under this Section 9.01 to approve the particular form of any proposed amendment or waiver, but it shall be sufficient if such consent approves the substance thereof. Any such modification approved by the required Holders of any class of Notes will be binding on the Holders of the relevant class of Notes and each party to the Indenture.

After an amendment under this Section 9.01 becomes effective, the Issuer shall mail to the Holders a notice briefly describing such amendment. Any failure of the Issuer to mail such notice, or any defect therein, shall not, however, in any way impair or affect the validity of any such amendment.

After an amendment under this Section 9.01 becomes effective, it shall bind every Holder, whether or not notation thereof is made on any Note held by such Holder.

Section 9.02 Modification Without Consent of Holder. The Trustee may agree, without the consent of any Noteholder:

(a) To evidence the succession of a successor as the Trustee, the removal of the Trustee or the appointment of any separate or additional trustee or trustees and to define the rights, powers, duties and obligations conferred upon any such separate trustee or trustees or co-trustees;

(b) To correct, confirm or amplify the description of any property at any time subject to the lien of this Indenture or to convey, transfer, assign, mortgage or pledge any property to or with the Trustee;

(c) To cure any ambiguity in, correct or supplement any defective or inconsistent provision of, or add to or modify any other provisions and agreements in, the Indenture or any other Related Document, in any manner that will not, in the judgment of the Trustee, materially adversely affect the interests of the Holders of the Notes;

(d) To grant or confer upon the Trustee for the benefit of the Holders of the Notes any additional rights, remedies, powers, authority or security which may be lawfully granted or conferred and which are not contrary or inconsistent with the Indenture;

(e) To add to or modify the covenants or agreements to be observed by the Issuer, which are not contrary to the Indenture, to add Events of Default for the benefit of the Holders of the Notes;

(f) To comply with the requirements of the SEC or any regulatory body or any applicable law, rules or regulations; or

(g) To effect any indenture supplemental to the Indenture or any other amendment, modification, supplement, waiver or consent with respect to the Indenture or any other Related Document; provided, that such supplemental indenture, amendment, modification, supplement, waiver or consent will not adversely affect the interests of the Holders of the Notes in any material respect as confirmed in an Officer’s Certificate of the Issuer.

Section 9.03 Subordination and Priority of Payments. The subordination provisions contained in Section 3.07 and Article X hereof may not be amended or modified without the consent of each Noteholder of each class affected thereby. In no event shall the provisions set forth in Section 3.07 relating to the priority and payment of Expenses be amended or modified.

Section 9.04 Execution of Amendments by Trustee. In executing, or accepting the additional trusts created by, any amendment or modification to this Indenture permitted by this Article or the modifications thereby of the trusts created by this Indenture, the Trustee shall be entitled to receive, and shall be fully protected in relying upon, an Officer’s Certificate and an Opinion of Counsel stating that the execution of such amendment is authorized or permitted by this Indenture. The Trustee may, but shall not be obligated to, enter into any such amendment which affects the Trustee’s own rights, duties or immunities under this Indenture or otherwise.

Section 9.05 Conformity with Trust Indenture Act. Every indenture supplemental hereto pursuant to this Article IX shall conform to the requirements of the Trust Indenture Act as then in effect.

Section 10.01 Subordination of the Notes. (a) Each of the Issuer and the Trustee (on behalf of the Holders of each class of Notes) covenants and agrees, and each Holder, by its acceptance of a Note, covenants and agrees, that the Notes of each class will be issued subject to the provisions of this Article X; and each Holder, by its acceptance of a Note, agrees that all amounts payable on any Note will, to the extent and in the manner set forth in this Article X and Section 3.07 hereof, be subordinated in right of payment to the prior payment in full of all Expenses payable to the Service Providers pursuant to this Indenture and the Related Documents. In addition, each Holder of a Class B Note, by its acceptance of a Class B Note, agrees that all amounts payable on any Class B Note will, to the extent and in the manner set forth in this Article X and Section 3.07 hereof, be subordinated in right of payment to the payment in full of the Class A Notes. Any claim to payment so stated to be subordinated is referred to as a “Subordinated Claim”; each claim to payment to which another claim to payment is a Subordinated Claim is referred to as a “Senior Claim” with respect to such Subordinated Claim.

(b) If prior to the payment in full of all Senior Claims then due and payable, the Trustee or any Holder of a Subordinated Claim shall have received any payment or distribution in respect of such Subordinated Claim in excess of the amount to which such Holder was then entitled under Section 3.07 hereof, then such payment or distribution shall be received and held in trust by such Person and paid over or delivered to the Trustee for application as provided in such Section 3.07.

(c) If any Service Provider, the Trustee or Holder of any Senior Claim receives any payment in respect of any Senior Claim which is subsequently invalidated, declared preferential, set aside and/or required to be repaid to a trustee, receiver or other party, then, to the extent such payment is so invalidated, declared preferential, set aside and/or required to be repaid, such Senior Claim shall be revived and continue in full force and effect, and shall be entitled to the benefits of this Article X, all as if such payment had not been received.

(d) The Trustee (on its own behalf and on behalf of the Holders) and the Issuer each confirm that the payment priorities specified in Section 3.07 hereof shall apply in all circumstances.

(e) Each Holder, by its acceptance of a Note, authorizes and expressly directs the Trustee on its behalf to take such action as may be necessary or appropriate to effectuate the subordination provided in this Article X, and appoints the Trustee its attorney-in-fact for such purposes, including, in the event of any dissolution, winding up, liquidation or reorganization of the Issuer (whether in bankruptcy, insolvency, receivership, reorganization or similar proceedings or upon an assignment for the benefit of creditors or otherwise) any actions tending towards liquidation of the property and assets of the Issuer or the filing of a claim for the unpaid balance of its Notes in the form required in those proceedings.

(f) If payment on the Notes is accelerated as a result of an Event of Default, the Issuer shall promptly notify the holders of the Senior Claims of such acceleration.

(g) After all Senior Claims are paid in full and until the Subordinated Claims are paid in full, and to the extent that such Senior Claims shall have been paid with funds that would, but for the subordination pursuant to this Article X, have been paid to and retained by such holders of Subordinated Claims, the holders of Subordinated Claims shall be subrogated to the rights of holders of Senior Claims to receive payments applicable

to Senior Claims. A payment made under this Article X to holders of Senior Claims which otherwise would have been made to the holders of Subordinated Claims is not, as between the Issuer and the holders of Subordinated Claims, a payment by the Issuer.

(h) No right of any holder of any Senior Claim to enforce the subordination of any Subordinated Claim shall be impaired by an act or failure to act by the Issuer or the Trustee or by any failure by either the Issuer or the Trustee to comply with this Indenture.

(i) Each Holder by accepting a Note acknowledges and agrees that the foregoing subordination provisions are, and are intended to be, an inducement and a consideration to each holder of any Senior Claim, whether such Senior Claim was created or acquired before or after the issuance of such Holder’s claim, to acquire and continue to hold such Senior Claim and such holder of any Senior Claim shall be deemed conclusively to have relied on such subordination provisions in acquiring and continuing to hold such Senior Claim. Each holder of a Subordinated Claim agrees to comply with the provisions of Section 4.12 hereof.

Section 11.01 Discharge of Liability on the Notes. (a) When (i) the Issuer delivers to the Trustee all Outstanding Notes (other than Notes replaced pursuant to Section 2.08 hereof) for cancellation or (ii) all Outstanding Notes have become due and payable, whether at maturity or as a result of the mailing of a notice of an Optional Redemption pursuant to Section 3.09(a) hereof or any other Redemption pursuant to Section 3.09(c) hereof and the Issuer irrevocably deposits in the Redemption Account funds sufficient to pay at maturity or upon redemption all Outstanding Notes, including interest thereon to maturity or the Redemption Date (other than Notes replaced pursuant to Section 2.08), and if in either case the Issuer pays all other sums payable hereunder by the Issuer, then this Indenture shall, subject to Section 11.01(b), cease to be of further effect. The Trustee shall acknowledge satisfaction and discharge of this Indenture on demand of the Issuer accompanied by an Officer’s Certificate and an Opinion of Counsel, at the cost and expense of the Issuer, to the effect that any conditions precedent to a discharge of this Indenture have been met.

(b) Notwithstanding clause (a) above, the Issuer’s obligations in Section 8.01 and the Trustee’s obligations in Section 12.14 shall survive the satisfaction and discharge of this Indenture.

Section 12.01 Right of Trustee to Perform. If the Issuer for any reason fails to observe or punctually to perform any of its obligations to the Trustee, whether under this Indenture or any of the other Related Documents or otherwise, the Trustee shall have power (but shall have no obligation), on behalf of or in the name of the Issuer or otherwise, to perform such obligations and to take any steps which the Trustee may, in its absolute discretion, consider appropriate with a view to remedying, or mitigating the consequences of, such failure by the Issuer; provided that no exercise or failure to exercise this power by the Trustee shall in any way prejudice the Trustee’s other rights under this Indenture or any of the other Related Documents.

Section 12.02 Waiver. Any waiver by any party of any provision of this Indenture or any right, remedy or option hereunder shall only prevent and estop such party from thereafter enforcing such provision, right, remedy or option if such waiver is given in writing and only as to the specific instance and for the specific purpose for which such waiver was given. The failure or refusal of any party hereto to insist in any one or more instances, or in a course of dealing, upon the strict performance of any of the terms or provisions of this Indenture by any party hereto or the partial exercise of any right, remedy or option hereunder shall not be construed as a waiver or relinquishment of any such term or provision, but the same shall continue in full force and effect. No failure on the part of the Trustee to exercise, and no delay on its part in exercising, any right or remedy under this Indenture will operate as a waiver thereof, nor will any single or partial exercise of any right or remedy preclude any other or further exercise thereof or the exercise of any other right or remedy. The rights and remedies provided in this Indenture are cumulative and not exclusive of any rights or remedies provided by law.

Section 12.03 Severability. In the event that any provision of this Indenture or the application thereof to any party hereto or to any circumstance or in any jurisdiction governing this Indenture shall, to any extent, be invalid or unenforceable under any applicable statute, regulation or rule of law, then such provision shall be deemed inoperative to the extent that it is invalid or unenforceable and the remainder of this Indenture, and the application of any such invalid or unenforceable provision to the parties, jurisdictions or circumstances other than to whom or to which it is held invalid or unenforceable, shall not be affected thereby nor shall the same affect the validity or enforceability of this Indenture. The parties hereto further agree that the holding by any court of competent jurisdiction that any remedy pursued by the Trustee hereunder is unavailable or unenforceable shall not affect in any way the ability of the Trustee to pursue any other remedy available to it.

Section 12.04 Restrictions on Exercise of Certain Rights. The Trustee and, during the continuance of a payment Default with respect to the Senior Class of Notes, the Senior Trustee, in its capacity as trustee of such class and except as otherwise provided in Section 4.04, may sue for recovery or take any other steps for the purpose of recovering any of the obligations hereunder or any other debts or liabilities whatsoever owing to it by the Issuer. Each of the Noteholders shall at all times be deemed to have agreed by virtue of the acceptance of the Notes that only the Trustee and, during the continuance of a payment Default with respect to the Senior Class of Notes, the Senior Trustee, in its capacity as trustee and except as provided in Section 4.04, may take any steps for the purpose of procuring the appointment of an administrative receiver, examiner, receiver or similar officer or the making of an administration order or for instituting any bankruptcy, reorganization, arrangement, insolvency, winding up, liquidation, composition, examination or any like proceedings under the laws of Delaware.

Section 12.05 Notices. All notices, demands, certificates, requests, directions, instructions and communications hereunder (“Notices”) shall be in writing and shall be effective (a) upon receipt when sent through the mails, registered or certified mail, return receipt requested, postage prepaid, with such receipt to be effective the date of delivery indicated on the return receipt, or (b) one Business Day after delivery to an overnight courier, or (c) on the date personally delivered to an authorized officer of the party to which sent, or (d) on the date transmitted by legible telecopier transmission with a confirmation of receipt, or (e) in the case of reports under Article III hereof and any other report which is of a routine nature, on the date transmitted by electronic mail or sent by first class mail or transmitted by legible telecopier transmission, in all cases addressed to the recipient as follows:

A copy of each notice given hereunder to any party hereto shall also be given to each of the other parties hereto. Each party hereto may, by notice given in accordance herewith to each of the other parties hereto, designate any further or different address to which subsequent Notices shall be sent.

Section 12.06 Assignments. This Indenture shall be a continuing obligation of the Issuer and shall (i) be binding upon the Issuer and its successors and assigns and (ii) inure to the benefit of and be enforceable by the Trustee, and by its successors, transferees and assigns. The Issuer may not assign any of its obligations under the Indenture, or delegate any of its duties hereunder.

Section 12.08 Application to Court. The Trustee may at any time after the service of an Acceleration Notice apply to any court of competent jurisdiction for an order that the terms of this Indenture be carried into execution under the direction of such court and for the appointment of a Receiver of the Collateral or any part thereof and for any other order in relation to the administration of this Indenture as the Trustee shall deem fit and it may assent to or approve any application to any court of competent jurisdiction made at the instigation of any of the Noteholders and shall be indemnified by the Issuer against all costs, charges and expenses incurred by it in relation to any such application or proceedings.

Section 12.09 Governing Law. THIS INDENTURE SHALL IN ALL RESPECTS BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK, INCLUDING ALL MATTERS OF CONSTRUCTION, VALIDITY AND PERFORMANCE.

Section 12.10 Jurisdiction. (a) Each of the parties hereto agrees that the U.S. federal and New York State courts located in The City of New York shall have jurisdiction to hear and determine any suit, action or proceeding, and to settle any disputes, which may arise out of or in connection with this Indenture and, for such purposes, submits to the jurisdiction of such courts. Each of the parties hereto waives any objection which it might now or hereafter have to the U.S. federal or New York State courts located in The City of New York being nominated as the forum to hear and determine any suit, action or proceeding, and to settle any disputes, which may arise out of or in connection with this Indenture and agrees not to claim that any such court is not a convenient or appropriate forum. Each of the parties hereto agrees that the process by which any suit, action or proceeding is begun may be served on it by being delivered in connection with any suit, action or proceeding in The City of New York to the Person named as the process agent of such party in Exhibit F at the address set out therein or at the principal New York City office of such process agent, if not the same.

(b) The submission to the jurisdiction of the courts referred to in Section 12.10(a) shall not (and shall not be construed so as to) limit the right of the Trustee to take proceedings against the Issuer in any other court of competent jurisdiction nor shall the taking of proceedings in any one or more jurisdictions preclude the taking of proceedings in any other jurisdiction, whether concurrently or not.

(c) Each of the parties hereto hereby consents generally in respect of any legal action or proceeding arising out of or in connection with this Indenture to the giving of any relief or the issue of any process in connection with such action or proceeding, including the making, enforcement or execution against any property whatsoever (irrespective of its use or intended use) of any order or judgment which may be made or given in such action or proceeding.

Section 12.11 Counterparts. This Indenture may be executed in one or more counterparts by the parties hereto, and each such counterpart shall be considered an original and all such counterparts shall constitute one and the same instrument.

Section 12.12 Table of Contents, Headings, Etc. The Table of Contents and headings of the Articles and Sections of this Indenture have been inserted for convenience of reference only, are not to be considered a part hereof and shall in no way modify or restrict any of the terms and provisions hereof.

Section 12.13 Trust Indenture Act. This Indenture shall not be qualified under the Trust Indenture Act and shall not be subject to the provisions of the Trust Indenture Act, although it shall incorporate such provisions for ease of reference.

Section 12.14 Confidential Information. The Trustee, in its individual capacity and as Trustee, agrees and acknowledges that all Confidential Information provided to the Trustee by NPS or Amgen is considered to be proprietary and confidential information of NPS or Amgen, as applicable. The Trustee agrees to take all reasonable precautions necessary to keep the Confidential Information confidential, which precautions shall be no less stringent than those which the Trustee employs to protect its own confidential information. The Trustee shall not disclose to any third party other than as set forth below, and shall not use for any purpose other than the exercise of the Trustee’s rights and the performance of its obligations under this Indenture, any Confidential Information of Amgen without the prior written consent of Amgen. The Trustee shall limit access to Confidential Information received hereunder to (i) its directors, officers and employees, and (ii) its legal advisors, to each of whom disclosure of Confidential Information is necessary for the purposes described above; provided, however, that in each case such party has expressly agreed to maintain such Confidential Information in confidence under terms and conditions substantially identical to the terms of this Section 12.14.

The Trustee agrees that Amgen has no responsibility whatsoever for any reliance on Confidential Information by the Trustee or by any person to whom the Confidential Information is disclosed in connection with this Indenture, whether related to the purposes described above or otherwise. Without limiting the generality of the foregoing, the Trustee agrees that Amgen makes no representation or warranty whatsoever to it with respect to Confidential Information or its suitability for such purposes. The Trustee further agrees that it shall not acquire any rights against Amgen or any employee, officer, director, representative or agent of Amgen (together with Amgen, “Amgen Parties”) as a result of the disclosure of Confidential Information to the Trustee or to any Noteholder or Beneficial Holder and that no Amgen Party has any duty, responsibility, liability or obligation to any Person as a result of any such disclosure.

In the event the Trustee is required to disclose any Confidential Information received hereunder in order to comply with any laws, regulations or court orders, it may disclose such Confidential Information only to the extent necessary for such compliance, provided, however, that it shall give Amgen reasonable advance written notice of any such court proceeding in which such disclosure may be required pursuant to a court order so as to afford Amgen a full and fair opportunity to oppose the issuance of such order and to appeal therefrom and shall cooperate reasonably with Amgen in opposing such order and in securing confidential treatment of any Confidential Information to be disclosed and/or obtaining a protective order narrowing the scope of such disclosure.

The Trustee agrees that Amgen is an express third-party beneficiary of the provisions of this Section 12.14.

IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly executed, all as of the date first written above.


CINACALCET ROYALTY SUB LLC, as Issuer

By:		/s/ Hunter Jackson
Name:		Hunter Jackson
Title:		President

U.S. BANK NATIONAL ASSOCIATION, not in its individual capacity but solely as Trustee

By:		/s/ Lori-Anne Rosenberg
Name:		Lori-Anne Rosenberg
Title:		Vice President

CINACALCET ROYALTY SUB LLC, a limited liability company organized under the laws of the State of Delaware (herein referred to as the “Issuer”), for value received, hereby promises to pay to CEDE & CO., or registered assigns, the principal sum set forth on Schedule I on or before March 30, 2017 (the “Final Maturity Date”) and to pay interest quarterly in arrears on the Outstanding Principal Balance hereof at a rate per annum equal to 8.0% (the “Stated Interest Rate”), from the date hereof until the Outstanding Principal Balance hereof is paid or duly provided for, which interest shall be due on each Payment Date and payable not later than the immediately succeeding Payment Date (together with Additional Interest on the amount of unpaid interest from the Payment Date on which it was due until the date on which it is paid, compounded quarterly on each Payment Date). If a B&W Payment or Amgen Payment is made, whether by the Trustee pursuant to Section 3.08 of the Indenture or by Amgen as a payment or offset to discharge a liability of NPS to Amgen, the Stated Interest Rate shall be increased by 0.75% during the period beginning on the first day any such B&W Payment or an Amgen Payment is outstanding and ending on the date on which NPS has reimbursed the entire amount of such B&W Payment or Amgen Payment and all other B&W Payments and Amgen Payments together with the entire amount of the increase in the Stated Interest Rate imposed by this sentence. Interest on this Class A Note in each Interest Accrual Period shall be calculated on the basis of a 360-day year and the actual number of days elapsed in such Interest Accrual Period.

This Class A Note is a duly authorized issue of Notes of the Issuer, designated as its “Secured 8% Notes, due 2017”, issued under the Indenture dated as of December 22, 2004 (as amended or supplemented from time to time, the “Indenture”), between the Issuer and U.S. Bank National Association, as Trustee (the “Trustee”). The Indenture also provides for the issuance of Class B Notes. All capitalized terms used in this Note and not defined herein shall have the respective meanings assigned to such terms in the Indenture. Reference is made to the Indenture and all indentures supplemental thereto for a statement of the respective rights and obligations thereunder of the Issuer, the Trustee, the Class A Noteholders and the Class B Noteholders, if any. This Class A Note is subject to all terms of the Indenture.

The Issuer will pay the Outstanding Principal Balance of this Class A Note prior to the Final Maturity Date on the Payment Dates and in the amounts specified in the Indenture, subject to the availability of the Available Collections Amount therefor after making payments entitled to priority under Section 3.07 of the Indenture.

The Issuer may redeem all or part of the Outstanding Principal Balance of this Class A Note prior to the Final Maturity Date on the Payment Dates, in the amounts and under the circumstances specified in the Indenture.

Any amount of Premium or interest on this Class A Note that is not paid when due shall, to the fullest extent permitted by applicable law, bear interest (“Additional Interest”) at a fluctuating interest rate per annum equal to the Stated Rate of Interest from the date when due until such amount is paid or duly provided for, compounded quarterly and payable on the next succeeding Payment Date, subject to the availability of the Available Collections Amount therefor after making payments entitled to priority under Section 3.07 of the Indenture.

The indebtedness evidenced by the Class A Notes is, to the extent and in the manner provided in the Indenture, senior in right of payment to the right of payment of the Class B Notes, and this Class A Note is issued subject to such provisions. The maturity of this Class A Note is subject to acceleration upon the occurrence and during the continuance of the Events of Default specified in the Indenture.

This Class A Note is and will be secured by the collateral pledged as security therefor as provided in the Indenture.

Subject to and in accordance with the terms of the Indenture, there will be distributed quarterly on each Payment Date commencing on March 30, 2005, to the Person in whose name this Class A Note is registered at the

close of business on the Record Date with respect to such Payment Date, in the manner specified in Section 3.07 of the Indenture, such Person’s pro rata share (based on the aggregate percentage of the Outstanding Principal Balance of the Class A Notes held by such Person) of the aggregate amount distributable to all Holders of Class A Notes on such Payment Date.

All amounts payable in respect of this Class A Note shall be payable in U.S. dollars in the manner provided in the Indenture to the Holder hereof on the Record Date relating to such payment. The final payment with respect to this Class A Note, however, shall be made only upon presentation and surrender of this Class A Note by the Noteholder or its agent at the Corporate Trust Office or agency of the Trustee or Paying Agent specified in the notice given by the Trustee or Paying Agent with respect to such final payment. At such time, if any, as this Class A Note is issued in the form of one or more Definitive Notes, payments on a Payment Date shall be made by check mailed to each Noteholder of such a Definitive Note on the applicable Record Date at its address appearing on the Register maintained with respect to the Class A Notes. Alternatively, upon application in writing to the Trustee, not later than the applicable Record Date, by a Noteholder, any such payments shall be made by wire transfer to an account designated by such Noteholder at a financial institution in New York, New York. The final payment with respect to any such Definitive Note, however, shall be made only upon presentation and surrender of such Definitive Note by the Noteholder or its agent at the Corporate Trust Office or agency of the Trustee or Paying Agent specified in the notice of such final payment given by the Trustee or Paying Agent. Any reduction in the principal amount of this Class A Note (or any one or more predecessor Class A Notes) effected by any payments made on any Payment Date shall be binding upon all future Holders of this Class A Note and of any Class A Note issued upon the registration of transfer of, in exchange or in lieu of or upon the refinancing of this Class A Note, whether or not noted hereon.

The Holder of this Class A Note agrees, by acceptance hereof, to pay over to the Trustee any money (including principal, Premium and interest) paid to it in respect of this Note in the event that the Trustee, acting in good faith, determines subsequently that such monies were not paid in accordance with the priority of payment provisions of the Indenture or as a result of any other mistake of fact or law on the part of the Trustee in making such payment.

This Class A Note is issuable only in registered form. A Holder may transfer this Note only by delivery of a written application to the Registrar stating the name of the proposed transferee, a Confidentiality Agreement duly executed by such transferee and by otherwise complying with the terms of the Indenture. No such transfer shall be effected until, and such transferee shall succeed to the rights of a Holder only upon, final acceptance and registration of the transfer by the Registrar in the Register. When this Class A Note is presented to the Registrar with a request to register the transfer or to exchange it for an equal principal amount of Class A Notes of other authorized denominations, the Registrar shall register the transfer or make the exchange as requested if its requirements for such transactions are met (including, in the case of a transfer, that such Note is duly endorsed or accompanied by a written instrument of transfer in form satisfactory to the Trustee and Registrar duly executed by the Holder thereof or by an attorney who is authorized in writing to act on behalf of the Holder and that the transferee has executed and delivered a Confidentiality Agreement to the Issuer). No service charge shall be made for any registration of transfer or exchange of this Class A Note, but the party requesting such new Note or Notes may be required to pay a sum sufficient to cover any transfer tax or similar governmental charge payable in connection therewith. This Class A Note may not be transferred to any Person engaged in the business of developing, manufacturing or marketing pharmaceutical or diagnostic products, or any Affiliate of such a Person.

Prior to the registration of transfer of this Class A Note, the Issuer and the Trustee may deem and treat the Person in whose name this Class A Note (as of the day of determination or as of such other date as may be specified in the Indenture) is registered as the absolute owner and Holder hereof for the purpose of receiving payment of all amounts payable with respect to this Class A Note and for all other purposes, and neither the Issuer nor the Trustee shall be affected by notice to the contrary.

The Indenture permits the amendment or modification of the Indenture and the Class A Notes by the Issuer with the consent of the Holders of a majority of the Outstanding Principal Balance of all Notes on the date of any vote of such Holders (voting as a single class); provided that, without the consent of Holders of one hundred percent (100%) of the Outstanding Principal Balance of the class of Notes affected thereby, no such amendment may (i) reduce the percentage of Holders of any such class of Notes required to take or approve any action hereunder; (ii) change the amount or the time of payment of any amount owing or payable with respect to any such class of Notes or change the rate or manner of calculation of interest payable with respect to any such class of Notes; (iii) alter or modify the provisions with respect to the Collateral for the Notes or the manner of payment or the order of priorities

in which payments or distributions hereunder will be made as between the Holders of such Notes and the Issuer; or (iv) consent to any assignment of the Issuer’s rights to a party other than the Trustee for the benefit of the Noteholders (each, a “Basic Terms Modification”). Any such amendment or modification shall be binding on every Holder hereof, whether or not notation thereof is made upon this Class A Note. The Indenture also permits the Trustee to agree, without the consent of any Noteholder, (a) to any modification (other than a Basic Terms Modification) of, or the waiver or authorization of any breach or prospective breach of, any provision of any Related Document or of the relevant Notes to correct a manifest error or an error which is of a formal, minor or technical nature or (b) to modify the provisions of the Indenture or the Purchase and Sale Agreement relating to the timing of movement of monies received among the Accounts by the Trustee.

The subordination provisions contained in Section 3.07 and Article X of the Indenture may not be amended or modified without the consent of each Noteholder of the class affected thereby and each Noteholder of the class of Notes ranking senior thereto.

The Indenture also contains provisions permitting the Holders of Notes representing a majority of the Outstanding Principal Balance of the Senior Class of Notes, on behalf of the Holders of all of the Class A Notes, to waive compliance by the Issuer with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver shall be conclusive and binding upon all present and future Holders of this Class A Note and of any Class A Note issued upon the registration of transfer of, in exchange or in lieu of or upon the refinancing of this Class A Note, whether or not notation of such consent or waiver is made upon this Class A Note.

The term “Issuer” as used in this Class A Note includes any successor to the Issuer under the Indenture.

The Issuer is permitted by the Indenture, under certain circumstances, to merge or consolidate, subject to the rights of the Trustee and the Holders of Class A Notes under the Indenture.

The Class A Notes are issuable only in registered form in denominations as provided in the Indenture, subject to certain limitations therein set forth.

This Class A Note shall in all respects be governed by, and construed in accordance with, the laws of the State of New York, including all matters of construction, validity and performance.

Unless the certificate of authentication hereon has been executed by the Trustee whose name appears below by manual or facsimile signature, this Class A Note shall not be entitled to any benefit under the Indenture, or be valid or obligatory for any purpose.

IN WITNESS WHEREOF, the Issuer has caused this Class A Note to be signed manually or by facsimile by its duly authorized Manager.

This Class A Note is one of the Secured 8% Notes due 2017 designated above and referred to in the within-mentioned indenture.

FOR VALUE RECEIVED the undersigned registered holder hereby sell(s), assign(s) and transfer(s) unto

the within Note and all rights thereunder, hereby irrevocably constituting and appointing

attorney to transfer said Note on the books of the Issuer with full power of substitution in the premises.

NOTE: The signature to this assignment must correspond with the name as written upon the face of the within-mentioned instrument in every particular, without alteration or any change whatsoever.

In connection with any transfer of this Note occurring prior to the date which is the end of the period referred to in Rule 144(k) under the Securities Act, the undersigned confirms that without utilizing any general solicitation or general advertising that:

¨ (a) this Note is being transferred in compliance with the exemption from registration under the Securities Act of 1933 provided by Rule 144A thereunder.

¨ (b) this Note is being transferred other than in accordance with (a) above and documents are being furnished which comply with the conditions of transfer set forth in this Note and the Indenture.

If none of the foregoing boxes is checked, the Trustee or other Registrar shall not be obligated to register this Note in the name of any Person other than the Holder hereof unless and until the conditions to any such transfer of registration set forth herein and in Section 2.11 of the Indenture shall have been satisfied.

The undersigned represents and warrants that it is purchasing this Note for its own account or an account with respect to which it exercises sole investment discretion and that it and any such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act of 1933 and is aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and that it is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption from registration provided by Rule 144A.

This letter relates to U.S. $ principal amount of Class Notes of the Issuer represented by a Class Note which bears a legend (the “Legended Note”) outlining restrictions upon transfer of such Legended Note. Pursuant to Section 2.01 of the Indenture dated as of December 22, 2004 (the “Indenture”) relating to the Class Notes and certain other classes of Notes, we hereby certify that we are (or we will hold such securities on behalf of) a person outside the United States to whom the Class Notes may be transferred in accordance with Rule 904 of Regulation S promulgated under the U.S. Securities Act of 1933, as amended (“Regulation S”). Accordingly, you are hereby requested to exchange the Legended Note for an unlegended Note representing an identical principal amount of Class Notes, all in the manner provided for in the Indenture.

Each of you is entitled to rely upon this letter and is irrevocably authorized to produce this letter or a copy hereof to any interested party in any administrative or legal proceedings or official inquiry with respect to the matters covered hereby. Terms used in this certificate have the meanings set forth in Regulation S.

FORM OF CERTIFICATE TO BE DELIVERED IN CONNECTION WITH TRANSFERS PURSUANT TO REGULATION S

In connection with our proposed sale of U.S.$ aggregate principal amount of the Class Notes, we confirm that such sale has been effected pursuant to and in accordance with Regulation S under the Securities Act of 1933, as amended (“Regulation S”) and, accordingly, we represent that:

(2) at the time the buy order was originated, the transferee was outside the U.S. or we and any person acting on our behalf reasonably believed that the transferee was outside the U.S.;

(3) no directed selling efforts have been made by us in the U.S. in contravention of the requirements of Rule 903(b) or Rule 904(b) of Regulation S, as applicable;

(4) the transaction is not part of a plan or scheme to evade the registration requirements of the U.S. Securities Act of 1933; and

(5) we are not engaged in, and are not an affiliate of any firm, corporation, partnership, association, trust or other legal entity engaged in, the business of developing, manufacturing or marketing pharmaceutical or diagnostic products.

In connection with our proposed purchase of Notes (the “Notes”) of Cinacalcet Royalty Sub LLC (the “Issuer”), we confirm that:

1. We have duly executed and delivered to the Issuer a Confidentiality Agreement and have subsequently received a copy of the Private Placement Memorandum dated December 14, 2004 (the “Private Placement Memorandum”) relating to the Notes and such other information as we deem necessary in order to make our investment decision. We acknowledge that we have read and agreed to the matters stated in the section entitled “Transfer Restrictions” of such Private Placement Memorandum and the restrictions on duplication and circulation of such Private Placement Memorandum.

2. We understand that any subsequent transfer of the Notes is subject to certain restrictions and conditions set forth in the Private Placement Memorandum under “Transfer Restrictions” and the undersigned agrees to be bound by, and not to resell, pledge or otherwise transfer the Notes except in compliance with such restrictions and conditions and the Securities Act of 1933, as amended (the “Securities Act”).

3. We understand that the offer and sale of the Notes have not been registered under the Securities Act, that the Notes will only be in the form of definitive physical certificates and that the Notes may not be offered or sold except as permitted in the following sentence. We agree, on our own behalf and on behalf of any accounts for which we are acting as hereinafter stated, that if we should sell any Notes in the future, we will do so only (1) (A) to the Issuer or any subsidiary thereof, (B) in accordance with Rule 144A under the Securities Act to a “qualified institutional buyer” (as defined therein), (C) to an institutional “accredited investor” (as defined below) that, prior to such transfer, furnishes to the Trustee (as defined in the Indenture) a signed letter containing certain representations and agreements relating to the restrictions on transfer of the Notes (the form of which letter can be obtained from the Trustee) and an opinion of counsel acceptable to the Issuer that such transfer is in compliance with the Securities Act, (D) in an offshore transaction in compliance with Rule 904 of Regulation S under the Securities Act, (E) pursuant to the exemption from registration provided by Rule 144 under the Securities Act (if available) or pursuant to another available exemption from registration under the Securities Act, as applicable or (F) pursuant to an effective registration statement under the Securities Act, and we further agree to provide to any person purchasing any of the Notes from us a notice advising such purchaser that resales of the Notes are restricted as stated herein and (2) in each case, in accordance with any applicable securities laws of any state in the U.S. or any other applicable jurisdiction and in accordance with the legend to be set forth in the Notes, which will reflect the substance of this paragraph.

4. We understand that, on any proposed resale of any Notes, we will be required to furnish to the Issuer and the Trustee such certifications, legal opinions and other information as the Issuer and the Trustee may reasonably require to confirm that the proposed sale complies with the foregoing restrictions.

5. We are an institutional “accredited investor” (as defined in Rule 501(a)(1), (2), (3) or (7) of Regulation D under the Securities Act) and have such knowledge and experience in financial and business matters as to be capable of evaluating the merits and risks of our investment in the Notes, and we and any accounts for which we are acting are each able to bear the economic risks of our or their investment.

6. We are acquiring the Notes purchased by us for our own account or for one or more accounts (each of which is an institutional “accredited investor”) as to each of which we exercise sole investment discretion.

7. We are not acquiring the Notes with a view to distribution thereof or with any present intention of offering or selling the Notes, except as permitted above, provided that the disposition of our property and property of any accounts for which we are acting as fiduciary shall remain at all times within our control.

8. We represent that we are not engaged in, and are not an affiliate of any any firm, corporation, partnership, association, trust or other legal entity engaged in, the business of developing, manufacturing or marketing pharmaceutical or diagnostic products.

You, the Issuer and the Trustee are entitled to rely upon this letter and are irrevocably authorized to produce this letter or a copy hereof to any interested party in any administrative or legal proceedings or official inquiry with respect to the matters covered hereby.

Reference is hereby made to the Indenture, dated as of December 22, 2004 (the “Indenture”), made by and between Cinacalcet Royalty Sub LLC (the “Issuer”) and U.S. Bank National Association, as Trustee (the “Trustee”). Capitalized terms used but not defined herein shall have the meanings given to them in the Indenture.

This letter relates to $[ ] principal amount of Class Notes that are held in the form of a beneficial interest in the Temporary Regulation S Global Note (CUSIP No. ) through [insert name of DTC] by the undersigned (the “Holder”) in the name of [insert name of Participant]. The Holder of such Temporary Regulation S Global Note hereby requests the receipt of payment of interest installments due and payable [on the applicable Payment Date] pursuant to Section 2.05 of the Indenture.

The Holder hereby represents and warrants that it (i) is not a U.S. person, (ii) does not hold the above-referenced Temporary Regulation S Global Note for the account or benefit of a U.S. person (other than a distributor), (iii) has executed and delivered a Confidentiality Agreement to the Issuer, and (iv) is not engaged in, and is not an affiliate of any Person engaged in, the business of developing, manufacturing or marketing pharmaceutical or diagnostic products. Terms in this certificate have the meanings given to them in Regulation S under the Securities Act of 1933, as amended.

This certificate and the statements contained herein are made for your benefit and the benefit of the Paying Agent.


[Name of Holder]

By:
Name:
Title:

Reference is hereby made to the Indenture, dated as of December 22, 2004 (the “Indenture”), made by and between Cinacalcet Royalty Sub LLC (the “Issuer”) and U.S. National Association, as Trustee (the “Trustee”). Capitalized terms used but not defined herein shall have the meanings given to them in the Indenture.

This letter relates to $[ ] principal amount of Class Notes that are held in the form of a beneficial interest in the Temporary Regulation S Global Note (CUSIP No. ) through [insert name of DTC] by the undersigned (the “Holder”) in the name of [insert name of Participant]. Certain Holders of the beneficial interests in such Temporary Regulation S Global Note have requested the receipt of payment of interests installments due and payable [on the applicable Payment Date] pursuant to Section 2.05 of the Indenture.

We have received from such Holders certifications to the effect that they (i) are not U.S. persons, (ii) do not hold the above-referenced Temporary Regulation S Global Note for the account or benefit of U.S. persons (other than distributors), (iii) has executed and delivered a Confidentiality Agreement to the Issuer, and (iv) is not engaged in, and is not an affiliate of any Person engaged in, the business of developing, manufacturing or marketing pharmaceutical or diagnostic products. Terms in this certificate have the meanings given to them in Regulation S under the Securities Act of 1933, as amended.

Accordingly, the Holders of the beneficial interests in the Temporary Regulation S Global Note are entitled to receive interest, principal and premium, if any, in accordance with the terms of the Indenture in the amount of $[ ].


[Clearstream] [Euroclear]

By:
Name:
Title:

In connection with our interest in the potential purchase of Cinacalcet Pharmaceutical Royalty Monetization Asset (PhaRMA^SM) Secured 8% Notes due 2017 issued by you (the “Notes”), we have requested that you furnish us with the Private Placement Memorandum, dated December 14, 2004, relating to the Notes (the “Private Placement Memorandum”). In addition to receiving the Private Placement Memorandum, we may also have conversations with you or your representatives or receive additional information from you or your representatives about the Notes or your business. As used in this letter agreement, the term “Information” means (i) the Private Placement Memorandum, (ii) any additional information we receive from you or your representatives about the Notes or your business, and (iii) any internal reports or analyses we prepare that incorporate or utilize any information described in clauses (i) or (ii) (in the case of clauses (ii) and (iii), whether oral or written, whether in tangible or electronic form, or otherwise). The term Information also includes all confidential and proprietary information of Amgen, Inc. (“Amgen”) related to that certain Development and License Agreement by and between NPS Pharmaceuticals, Inc. (“NPS”) and Amgen, effective as of December 27, 1995, as amended (the “License Agreement”), including but not limited to product sales and royalties paid under the License Agreement, the business and operations of Amgen, Amgen finances, and such other information relating thereto as may be provided by you, NPS or Amgen (“Amgen Information”). The term Information will not, however, include information which (i) is or becomes publicly available other than as a result of a disclosure by us, (ii) was already known to us, as evidenced by our contemporaneous written records at the time of disclosure by you or (iii) was disclosed to us by a third party who, to the best of our knowledge, had no obligation to you, NPS or Amgen not to disclose such information to others.

We represent and warrant that we are not in the business of developing, manufacturing or marketing pharmaceutical or diagnostic products. We represent and warrant that we are not an affiliate of an entity which is in the business of developing, manufacturing or marketing pharmaceutical or diagnostic products.

Please confirm your agreement with the foregoing by signing and returning to the undersigned the duplicate copy of this letter enclosed herewith.


Very truly yours,

[Please Print Name]

By:

Name:

Title:

Address:


Party	Jurisdiction	Appointed Agent
Cinacalcet Royalty Sub LLC	Delaware	The Corporation Trust Company

Cinacalcet Royalty Sub LLC	New York	CT Corporation System


Quarter Ending	Amounts
December 31, 2004	$	12,825,000
March 31, 2005		14,476,092
June 30, 2005		18,068,769
September 30, 2005		24,034,898
December 31, 2005		33,842,418
March 31, 2006		48,705,167
June 30, 2006		63,677,983
September 30, 2006		77,038,828
December 31, 2006		87,947,779
March 31, 2007		96,504,963
June 30, 2007		105,285,069
September 30, 2007		114,827,428
December 31, 2007		125,097,113
March 31, 2008		135,913,672
June 30, 2008		146,281,143
September 30, 2008		156,097,862
December 31, 2008		165,336,054
March 31, 2009		173,830,524
June 30, 2009		181,255,492
September 30, 2009		187,913,903
December 31, 2009		193,887,563
March 31, 2010		199,187,476
June 30, 2010		203,576,272
September 30, 2010		207,158,157
December 31, 2010		210,013,208
March 31, 2011		212,379,957
June 30, 2011		214,739,859
September 30, 2011		217,166,078
December 31, 2011		219,718,463
March 31, 2012		222,404,146
June 30, 2012		225,118,352
September 30, 2012		227,821,531
December 31, 2012		230,525,414
March 31, 2013		233,254,024
June 30, 2013		236,034,795
September 30, 2013		238,854,512
December 31, 2013		241,705,556
March 31, 2014		244,591,805
June 30, 2014		247,515,872
September 30, 2014		250,474,741
December 31, 2014		253,467,515
March 31, 2015		256,496,160
June 30, 2015		259,568,579
September 30, 2015		262,681,005
December 31, 2015		265,839,962
March 31, 2016		269,016,180
June 30, 2016		272,238,568
September 30, 2016		275,502,917
December 31, 2016		278,816,068


		Page
GRANTING CLAUSE		1

HABENDUM CLAUSE		2

Article I
DEFINITIONS

Section 1.01	Definitions	3
Section 1.02	Rules of Construction	15
Section 1.03	Compliance Certificates and Opinions	16
Section 1.04	Acts of Noteholders	16

Article II
THE NOTES

Section 2.01	Amount Not to Exceed the Initial Outstanding Principal Balance; Terms; Form; Execution and Delivery	17
Section 2.02	Restrictive Legends	19
Section 2.03	Registrar and Paying Agent	21
Section 2.04	Paying Agent to Hold Money in Trust	22
Section 2.05	Method of Payment	22
Section 2.06	Minimum Denomination	23
Section 2.07	Transfer and Exchange; Cancellation	23
Section 2.08	Mutilated, Destroyed, Lost or Stolen Notes	23
Section 2.09	Payments of Transfer Taxes	24
Section 2.10	Book-Entry Provisions	24
Section 2.11	Special Transfer Provisions	25
Section 2.12	Temporary Definitive Notes	28
Section 2.13	Statements to Noteholders	28
Section 2.14	CUSIP, CINS AND ISIN Numbers	29
Section 2.15	Refinancing Notes	29
Section 2.16	Class B Notes	30
Section 2.17	Contingent Payment Status	32

Article III
ACCOUNTS; PRIORITY OF PAYMENTS

Section 3.01	Establishment of Accounts	32
Section 3.02	Investments of Cash	33
Section 3.03	Closing Date Deposits, Withdrawals and Transfers	33
Section 3.04	Capital Contributions; Interest Reserve Amount.	34
Section 3.05	Calculation Date Calculations	34
Section 3.06	Payment Date First Step Transfers	35
Section 3.07	Payment Date Second Step Withdrawals	35
Section 3.08	B&W Payment/Amgen Payment	36
Section 3.09	Redemptions	36
Section 3.10	Procedure for Redemptions	37


Article IV
DEFAULT AND REMEDIES

Section 4.01	Events of Default	38
Section 4.02	Acceleration, Rescission and Annulment	38
Section 4.03	Other Remedies	39
Section 4.04	Limitation on Suits	40
Section 4.05	Waiver of Existing Defaults	40
Section 4.06	Restoration of Rights and Remedies	41
Section 4.07	Remedies Cumulative	41
Section 4.08	Authority of Courts Not Required	41
Section 4.09	Rights of Noteholders to Receive Payment	41
Section 4.10	Trustee May File Proofs of Claim	41
Section 4.11	Undertaking for Costs	41
Section 4.12	Control by Noteholders	41
Section 4.13	Controlling Party	42
Section 4.14	Application of Proceeds.	42
Section 4.15	Waivers of Rights Inhibiting Enforcement.	42

Article V
REPRESENTATIONS, WARRANTIES AND COVENANTS

Section 5.01	Representations and Warranties	42
Section 5.02	Covenants	44
Section 5.03	Reports by the Issuer	45

Article VI
THE TRUSTEE

Section 6.01	Acceptance of Trusts and Duties	45
Section 6.02	Absence of Duties	46
Section 6.03	Representations or Warranties	46
Section 6.04	Reliance; Agents; Advice of Counsel	46
Section 6.05	Not Acting in Individual Capacity	47
Section 6.06	Compensation of Trustee	47
Section 6.07	Notice of Defaults	47
Section 6.08	May Hold Notes	47
Section 6.09	Corporate Trustee Required; Eligibility	47
Section 6.10	Reports by the Trustee	48
Section 6.11	Calculation Agent	48
Section 6.12	Pledge Agreement	48

Article VII
SUCCESSOR TRUSTEES

Section 7.01	Resignation and Removal of Trustee	48
Section 7.02	Appointment of Successor	48

Article VIII
INDEMNITY

Section 8.01	Indemnity	49
Section 8.02	Noteholders’ Indemnity	49
Section 8.03	Survival	49


Article IX
MODIFICATION

Section 9.01	Modification with Consent of Holders	49
Section 9.02	Modification Without Consent of Holder	50
Section 9.03	Subordination and Priority of Payments	50
Section 9.04	Execution of Amendments by Trustee	51
Section 9.05	Conformity with Trust Indenture Act	51

Article X
SUBORDINATION

Section 10.01	Subordination of the Notes	51

Article XI
DISCHARGE OF INDENTURE

Section 11.01	Discharge of Liability on the Notes	52

Article XII
MISCELLANEOUS

Section 12.01	Right of Trustee to Perform	52
Section 12.02	Waiver	52
Section 12.03	Severability	53
Section 12.04	Restrictions on Exercise of Certain Rights	53
Section 12.05	Notices	53
Section 12.06	Assignments	54
Section 12.07	Reserved	54
Section 12.08	Application to Court	54
Section 12.09	Governing Law	54
Section 12.10	Jurisdiction	54
Section 12.11	Counterparts	54
Section 12.12	Table of Contents, Headings, Etc	55
Section 12.13	Trust Indenture Act	55
Section 12.14	Confidential Information	55


Exhibit A	-	Form of Class A Note
Exhibit F	-	List of Process Agents
Exhibit H	-	Form of Distribution Report
Exhibit I	-	Form of Certificate
Exhibit J	-	Form of Certificate to be Delivered in Connection with Transfers Pursuant to Regulation S
Exhibit K	-	Form of Certificate to be Delivered in Connection with Transfers to Non-QIB Accredited Investors
Exhibit M-1	-	Form of Certificate to DTC Regarding Interest
Exhibit M-2	-	Form of DTC Certificate Regarding Interest
Exhibit N	-	Form of Confidentiality Agreement



Date:		NOTICE: The signature to this assignment must correspond with the name as written upon the face of the within-mentioned instrument in every particular, without alteration or any change whatsoever.


Very truly yours,

[Euroclear] [Clearstream]

By:
		Authorized Signature


Very truly yours,

[Name of Transferor]

By:
		Authorized Signature


Accepted and Agreed as of the date first written above:

CINACALCET ROYALTY SUB LLC

By:

Name:

Title:

Private Placement Memorandum Copy No:


No.		CUSIP:

$