Exhibit 5.1

CONYERS DILL & PEARMAN LLP   Cricket Square, Hutchins Drive PO Box 2681, Grand Cayman KY1-1111 Cayman Islands   T +1 345 945 3901   conyers.com

June 9, 2023

+1 345 814 7382

Matthew.Stocker@conyers.com

Apollomics Inc.

Cricket Square

Hutchins Drive

PO Box 2681

Grand Cayman KY1-1111

Cayman Islands

Dear Sirs,

Re: Apollomics Inc. (the “Company”)

We have acted as special legal counsel in the Cayman Islands to the Company in connection with the Company’s Registration Statement on Form F-1 filed with the Securities and Exchange Commission in the United States (the “SEC”) on June 9, 2023 (as it may be amended, the “Registration Statement”) relating to the Company’s registration of (i) a primary offering of an aggregate of up to 11,560,602 class A ordinary shares, par value $0.0001 per share (“Ordinary Shares”) and (ii) a secondary offering of (a) 87,918,994 Ordinary Shares and (b) 619,400 warrants constituted by Warrant Agreements (the “Warrants”) to purchase Ordinary Shares; and (c) 676,900 Ordinary Shares (the “Warrant Shares”) to be issued upon the exercise of the Warrants (the Ordinary Shares, the Warrants and the Warrant Shares are collectively referred to herein as the “Registered Securities”), all as more particularly defined and described in the Registration Statement.

1. DOCUMENTS REVIEWED

For the purposes of giving this opinion, we have examined copies of:

(i) the Registration Statement;

(ii) the sixth amended and restated memorandum and articles of association (the “Constitutional Documents”) of the Company adopted with effect from 29 March 2023;

(iii) the form of the Warrants;

(iv) the resolutions in writing of the directors of the Company dated March 16, 2023 (the “Resolutions”);

(v) a certificate of good standing (the “Certificate of Good Standing”) dated June 9, 2023 issued by the registrar of companies (the “Registrar”) in relation to the Company; and

(vi) such other documents and made such enquiries as to questions of law as we have deemed necessary in order to render the opinion set forth below.

2. ASSUMPTIONS

We have assumed:

(a) the genuineness and authenticity of all signatures and the conformity to the originals of all copies of documents (whether or not certified) examined by us and the authenticity and completeness of the originals of documents from which such copies were taken;

(b) the accuracy and completeness of all factual representations made in the Registration Statement and other documents reviewed by us;

(c) the capacity, power and authority of each of the parties to the Warrants, other than the Company, to enter into and perform its respective obligations under the Warrants;

(d) the due execution and delivery of the Warrants by each of the parties thereto, other than the Company, and the physical delivery thereof by the Company with an intention to be bound thereby;

(e) that the resolutions contained in the Resolutions were passed by unanimous written resolutions of the directors of the Company, remain in full force and effect and have not been and will not be rescinded or amended;

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(f) the legality, validity and binding effect under the laws of New York (the “Foreign Laws”) of the Warrants, which are expressed to be governed by the Foreign Laws, in accordance with their respective terms;

(g) that there is no provision of the law of any jurisdiction, other than the Cayman Islands, which would have any implication in relation to the opinions expressed herein;

(h) that any Ordinary Shares and Warrant Shares shall have been issued by the Company against payment in full, which shall be equal to at least the par value thereof, and shall have been duly registered, and will continue to be registered, in the Company’s register of members;

(i) that the Company will have sufficient authorised capital to effect the issue of any Ordinary Shares and/or Warrant Shares at the time of issuance;

(j) that the Constitutional Documents are in force;

(k) the capacity, power and authority of all parties other than the Company to enter into and perform their obligations under any and all documents entered into by such parties in connection with the issuance of the Registered Securities, and the due execution and delivery thereof by each party thereto;

(l) the effectiveness under the laws of the United States of America of the Registration Statement and that the Registration Statement will be duly filed with and declared effective by the SEC;

(m) that the Registration Statement declared effective by the Commission will be in substantially the same form as that examined by us for purposes of this opinion; and

(n) that there is no provision of the law of any jurisdiction, other than the Cayman Islands, which would have any implication in relation to the opinions expressed herein.

3. QUALIFICATIONS

(a) The term “enforceable” as used in this opinion means that an obligation is of a type which the courts of the Cayman Islands enforce. It does not mean that those obligations will be enforced in all circumstances. In particular, the obligations of the Company in connection with any Registered Security, the Warrants and any indenture or other agreement or document relating thereto:

(i) will be subject to the laws from time to time in effect relating to bankruptcy, insolvency, liquidation, possessory liens, rights of set off, reorganisation, amalgamation, merger, consolidation, moratorium, bribery, corruption, money laundering, terrorist financing, proliferation financing or any other laws or legal procedures, whether of a similar nature or otherwise, generally affecting the rights of creditors as well as applicable international sanctions;

(ii) will be subject to statutory limitation of the time within which proceedings may be brought;

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(iii) will be subject to general principles of equity and, as such, specific performance and injunctive relief, being equitable remedies, may not be available;

(iv) may not be given effect to by a Cayman Islands court if and to the extent they constitute the payment of an amount which is in the nature of a penalty; and

(v) may not be given effect by a Cayman Islands court to the extent that they are to be performed in a jurisdiction outside the Cayman Islands and such performance would be illegal under the laws of that jurisdiction. Notwithstanding any contractual submission to the exclusive or non-exclusive jurisdiction of specific courts, a Cayman Islands court has inherent discretion to stay or allow proceedings in the Cayman Islands against the Company if there are other proceedings simultaneously underway against the Company in another jurisdiction.

(b) We have made no investigation of and express no opinion in relation to the laws of any jurisdiction other than the Cayman Islands.

(c) This opinion is to be governed by and construed in accordance with the laws of the Cayman Islands and is limited to and is given on the basis of the current law and practice in the Cayman Islands.

(d) This opinion is issued solely for the purposes of the filing of the Registration Statement and the offering of the Registered Securities by the Company and is not to be relied upon in respect of any other matter.

4. OPINIONS

On the basis of and subject to the foregoing, we are of the opinion that:

(a) The Company is duly incorporated with limited liability and existing under the laws of the Cayman Islands and, based on the Certificate of Good Standing, is in good standing. Pursuant to the Companies Act (Revised) of the Cayman Islands (the “Act”), a company is deemed to be in good standing if all fees and penalties under the Act have been paid and the Registrar has no knowledge that the Company is in default under the Act.

(b) The issue of the Ordinary Shares and the Warrant Shares has been duly authorised and, when issued and paid for in accordance with the Resolutions and the Registration Statement and entered on the register of members of the Company, the Ordinary Shares and/or the Warrant Shares, as the case may be, will be validly issued, fully paid and non-assessable (which term when used herein means that no further sums are required to be paid by the holders thereof in connection with the issue of such Ordinary Shares or Warrant Shares, as the case may be).

(c) The execution, delivery and performance of the Warrants have been authorised by and on behalf of the Company and, once the Warrants have been executed and delivered by any director or officer of the Company in accordance with the Resolutions, the Warrants shall have been duly executed and delivered on behalf of the Company and will constitute the legal, valid and binding obligations of the Company enforceable in accordance with their terms.

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We hereby consent to the filing of this opinion as an exhibit to the Registration Statement and to the references to our firm under the captions “Material Cayman Islands Tax Considerations”, “Enforceability of Civil Liabilities” and “Legal Matters” in the proxy statement/prospectus forming a part of the Registration Statement. In giving this consent, we do not hereby admit that we are experts within the meaning of Section 11 of the Securities Act of 1933 (as amended, the “Securities Act”) or that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the SEC promulgated thereunder.

Yours faithfully,

/s/ Conyers Dill & Pearman LLP

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