Exhibit 4.1

C0000000230 M ESSA Pharma Inc. Shares *0* 0 0 0 0 A BRITISH COLUMBIA BUSINESS CORPORATIONS ACT COMPANY THIS CERTIFIES THAT IS THE REGISTERED HOLDER OF CUSIP 29668H104 ISIN CA29668H1047 SEE REVERSE FOR CERTAIN DEFINITIONS FULLY PAID AND NON ASSESSABLE COMMON SHARES WITHOUT PAR VALUE IN THE CAPITAL OF ESSA Pharma Inc. in the Authorized share structure of the above named Company subject to the Articles of the Company transferable on the Central Securities Register of the Company by the registered holder in person or by attorney duly authorized in writing upon surrender of this certificate properly endorsed. This certificate is not valid unless countersigned by the Transfer Agent and Registrar of the Company. IN WITNESS WHEREOF the Company has caused this certificate to be signed on its behalf by the facsimile signatures of its duly authorized officers, at Vancouver, British Columbia. Dated: Jan 18, 2018 Chief Executive Officer COUNTERSIGNED AND REGISTERED COUNTERSIGNED AND REGISTERED COMPUTERSHARE TRUST COMPANY, N.A. COMPUTERSHARE INVESTOR SERVICES INC. (CANTON, MA, JERSEY CITY, NJ AND OR (VANCOUVER) (TORONTO) LOUISVILLE, KY) TRANSFER AGENT AND REGISTRAR TRANSFER AGENT AND REGISTRAR Chief Financial Officer By Authorized Officer Authorized Officer The shares represented by this certificate are transferable at the offices of Computershare Investor Services Inc. in Vancouver, BC and Toronto, ON or at the offices of Computershare Trust Company, N.A. in Canton, MA, Jersey City, NJ and Louisville, KY.

DATED    Signature of Shareholder Signature of Guarantor Signature Guarantee: The signature on this assignment must correspond with the name as written upon the face of the certificate(s), in every particular, without alteration or enlargement, or any change whatsoever and must be guaranteed by a major Canadian Schedule l chartered bank or a member of an acceptable Medallion Signature Guarantee Program (STAMP, SEivlP, lvlSP) The Guarantor must affix a stamp bearing the actual words “Signature Guaranteed”. In the USA, signature guarantees must be done by members of a “lvledall ion Signature Guarantee Program” only. Signature guarantees are not accepted from Treasury Branches, Credit Unions or Caisses Popu Iaires    unless they are members of the Stamp Medallion Program.    SECURITY INSTRUCTIONS- INSTRUCTIONS DE SECURITE 1111S IS WA1 CRMAI1KCD PAP LA, DO N01 ACCCPl WITIIOUT NOTINO Wil l CRMARK I·IOLI) TO l iGHT TO VERIFY W/\TFRMIIRK. PAPILH f lliGHANI~. NE PIIS ACCFPTFR SANS VFRIFIF.A I A PRFSFNCE DU FILIGRANE. POUI~ CE FAIRE, PLACER A LA LUMIERE.    EN COMP    V2    01