Exhibit 99.2

CONSENT OF SANDRA J. HORNING, M.D.

In connection with the filing by Revolution Medicines, Inc. (the “Company”) of its Registration Statement (the “Registration Statement”) on Form S-4 with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the “Securities Act”), I hereby consent, pursuant to Rule 438 of the Securities Act, to being named as a nominee to the board of directors of the Company in the Registration Statement and any and all amendments and supplements thereto. I also consent to the filing of this consent as an exhibit to such Registration Statement and any amendments and supplements thereto.

Dated: September 13, 2023

/s/ Sandra J. Horning, M.D.

Sandra J. Horning, M.D.