<SEC-DOCUMENT>0001567619-19-021187.txt : 20191113
<SEC-HEADER>0001567619-19-021187.hdr.sgml : 20191113
<ACCEPTANCE-DATETIME>20191113160329
ACCESSION NUMBER:		0001567619-19-021187
CONFORMED SUBMISSION TYPE:	13F-HR
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20190930
FILED AS OF DATE:		20191113
DATE AS OF CHANGE:		20191113
EFFECTIVENESS DATE:		20191113

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Third Security, LLC
		CENTRAL INDEX KEY:			0001542294
		IRS NUMBER:				541923091
		STATE OF INCORPORATION:			VA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		13F-HR
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	028-14815
		FILM NUMBER:		191213907

	BUSINESS ADDRESS:	
		STREET 1:		THE GOVERNOR TYLER
		STREET 2:		1881 GROVE AVENUE
		CITY:			RADFORD
		STATE:			VA
		ZIP:			24141
		BUSINESS PHONE:		5406337900

	MAIL ADDRESS:	
		STREET 1:		THE GOVERNOR TYLER
		STREET 2:		1881 GROVE AVENUE
		CITY:			RADFORD
		STATE:			VA
		ZIP:			24141
</SEC-HEADER>
<DOCUMENT>
<TYPE>13F-HR
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <filer>
        <credentials>
          <cik>0001542294</cik>
          <ccc>XXXXXXXX</ccc>
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      <periodOfReport>09-30-2019</periodOfReport>
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    <coverPage>
      <reportCalendarOrQuarter>09-30-2019</reportCalendarOrQuarter>
      <filingManager>
        <name>Third Security, LLC</name>
        <address>
          <com:street1>THE GOVERNOR TYLER</com:street1>
          <com:street2>1881 GROVE AVENUE</com:street2>
          <com:city>RADFORD</com:city>
          <com:stateOrCountry>VA</com:stateOrCountry>
          <com:zipCode>24141</com:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-14815</form13FFileNumber>
      <provideInfoForInstruction5>N</provideInfoForInstruction5>
    </coverPage>
    <signatureBlock>
      <name>Randal J. Kirk</name>
      <title>Chief Executive Officer</title>
      <phone>540-633-7900</phone>
      <signature>/s/ Randal J. Kirk</signature>
      <city>Radford</city>
      <stateOrCountry>VA</stateOrCountry>
      <signatureDate>11-13-2019</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
      <tableEntryTotal>14</tableEntryTotal>
      <tableValueTotal>667285</tableValueTotal>
      <isConfidentialOmitted>false</isConfidentialOmitted>
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<DOCUMENT>
<TYPE>INFORMATION TABLE
<SEQUENCE>2
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			<nameOfIssuer>AQUABOUNTY TECHNOLOGIES INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>03842K200</cusip>
			<value>2094</value>
			<shrsOrPrnAmt>
				<sshPrnamt>837554</sshPrnamt>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>837554</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
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			<nameOfIssuer>AQUABOUNTY TECHNOLOGIES INC</nameOfIssuer>
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			<cusip>03842K200</cusip>
			<value>20598</value>
			<shrsOrPrnAmt>
				<sshPrnamt>8239199</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>8239199</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ENERGY TRANSFER LP</nameOfIssuer>
			<titleOfClass>COM UT LTD PTN</titleOfClass>
			<cusip>29273V100</cusip>
			<value>14048</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1073990</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>1073990</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ENTERPRISE PRODS PARTNERS L</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>293792107</cusip>
			<value>32459</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1135734</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
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				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>FIBROCELL SCIENCE INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>315721407</cusip>
			<value>3631</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1226766</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>1226766</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>FIBROCELL SCIENCE INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>315721407</cusip>
			<value>1263</value>
			<shrsOrPrnAmt>
				<sshPrnamt>426720</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>426720</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>HALOZYME THERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>40637H109</cusip>
			<value>150541</value>
			<shrsOrPrnAmt>
				<sshPrnamt>9706087</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>9706087</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>INTREXON CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>46122T102</cusip>
			<value>428902</value>
			<shrsOrPrnAmt>
				<sshPrnamt>74982918</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>74982918</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>NUSTAR ENERGY LP</nameOfIssuer>
			<titleOfClass>UNIT COM</titleOfClass>
			<cusip>67058H102</cusip>
			<value>4112</value>
			<shrsOrPrnAmt>
				<sshPrnamt>145200</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>145200</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ORAGENICS INC</nameOfIssuer>
			<titleOfClass>COM PAR</titleOfClass>
			<cusip>684023302</cusip>
			<value>54</value>
			<shrsOrPrnAmt>
				<sshPrnamt>100056</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>100056</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
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		<infoTable>
			<nameOfIssuer>ORAGENICS INC</nameOfIssuer>
			<titleOfClass>COM PAR</titleOfClass>
			<cusip>684023302</cusip>
			<value>782</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1448110</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>PTC THERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>69366J200</cusip>
			<value>4652</value>
			<shrsOrPrnAmt>
				<sshPrnamt>137551</sshPrnamt>
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			<investmentDiscretion>SOLE</investmentDiscretion>
			<votingAuthority>
				<Sole>137551</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>QUAKER CHEM CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>747316107</cusip>
			<value>204</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1290</sshPrnamt>
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				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>TC PIPELINES LP</nameOfIssuer>
			<titleOfClass>UT COM LTD PRT</titleOfClass>
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			<value>3945</value>
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			<votingAuthority>
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				<None>0</None>
			</votingAuthority>
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</DOCUMENT>
</SEC-DOCUMENT>