SEC FORM 3

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Shacham Sharon

(Last)

(First)

(Middle)

C/O KARYOPHARM THERAPEUTICS INC.

2 MERCER ROAD

(Street)

NATICK

01760

(City)

(State)

(Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
11/05/2013

3. Issuer Name and Ticker or Trading Symbol
Karyopharm Therapeutics Inc. [ KPTI ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	C.S.O & Pres. of Res & Develop

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	1,001,713⁽¹⁾	D
Common Stock	620,771⁽¹⁾	I	By Spouse

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
Stock Option (right to buy)	⁽²⁾	09/02/2023	Common Stock	480,303⁽¹⁾	$4.75⁽¹⁾	D
Stock Option (right to buy)	⁽³⁾	10/21/2020	Common Stock	110,713⁽¹⁾	$0.03⁽¹⁾	D
Stock Option (right to buy)	⁽⁴⁾	11/01/2020	Common Stock	23,567⁽¹⁾	$0.03⁽¹⁾	D
Stock Option (right to buy)	⁽⁵⁾	12/14/2021	Common Stock	39,393⁽¹⁾	$0.26⁽¹⁾	D
Stock Option (right to buy)	⁽⁶⁾	12/14/2021	Common Stock	30,303⁽¹⁾	$0.26⁽¹⁾	D
Stock Option (right to buy)	⁽⁷⁾	12/14/2021	Common Stock	42,424⁽¹⁾	$0.26⁽¹⁾	I	By Spouse
Stock Option (right to buy)	⁽⁸⁾	12/14/2021	Common Stock	33,333⁽¹⁾	$0.26⁽¹⁾	I	By Spouse
Stock Option (right to buy)	⁽⁹⁾	09/02/2023	Common Stock	480,303⁽¹⁾	$4.75⁽¹⁾	I	By Spouse
Series A Convertible Preferred Stock	⁽¹⁰⁾	⁽¹⁰⁾	Common Stock	132,575⁽¹⁾	⁽¹⁰⁾	I	By Spouse

Explanation of Responses:

1. Reflects a 1-for-3.3 reverse stock split effected on October 25, 2013.

2. This option was granted on September 3, 2013. The shares underlying this option vest as to 25% of the shares on September 3, 2014, with the remaining 75% vesting in 36 equal monthly installments thereafter.

3. This option was granted on October 21, 2010. The shares underlying this option vest as to 25% of the shares on October 22, 2011, with the remaining 75% vesting in 36 equal monthly installments thereafter. The option is subject to an early exercise provision, which allows the reporting person to exercise the option as to the unvested shares (in addition to the vested shares), subject to the Issuer' right to repurchase any vested or unvested shares.

4. This option was granted on November 1, 2010. The shares underlying this option vest as to 25% of the shares on October 22, 2011, with the remaining 75% vesting in 36 equal monthly installments thereafter. The option is subject to an early exercise provision, which allows the reporting person to exercise the option as to the unvested shares (in addition to the vested shares), subject to the Issuer' right to repurchase any vested or unvested shares.

5. This option was granted on December 14, 2011. The shares underlying this option vest as to 25% of the shares on December 12, 2012, with the remaining 75% vesting in 36 equal monthly installments thereafter.

6. This option was granted on December 14, 2011. The shares underlying this option vest as to 25% of the shares on June 18, 2013, with the remaining 75% vesting in 36 equal monthly installments thereafter.

7. This option was granted on December 14, 2011. The shares underlying this option vest as to 25% of the shares on December 12, 2012, with the remaining 75% vesting in 36 equal monthly installments thereafter.

8. This option was granted on December 14, 2011. The shares underlying this option vest as to 25% of the shares on June 18, 2013, with the remaining 75% vesting in 36 equal monthly installments thereafter.

9. This option was granted on September 3, 2013. The shares underlying this option vest as to 25% of the shares on September 3, 2014, with the remaining 75% vesting in 36 equal monthly installments thereafter.

10. The Series A Convertible Preferred Stock is convertible into Common Stock on a 1-for-3.3 basis into the number of shares of Common Stock as shown in column 3 at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares have no expiration date.

	/s/ Sharon Shacham	11/05/2013
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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