-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 AxGoLSvYvg5w6ENdjJ7Idw==

<SEC-DOCUMENT>0001225208-10-001885.txt : 20100120
<SEC-HEADER>0001225208-10-001885.hdr.sgml : 20100120
<ACCEPTANCE-DATETIME>20100120153241
ACCESSION NUMBER:		0001225208-10-001885
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100119
FILED AS OF DATE:		20100120
DATE AS OF CHANGE:		20100120

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Sharry Sheryl G
		CENTRAL INDEX KEY:			0001478189

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27702
		FILM NUMBER:		10536179

	MAIL ADDRESS:	
		STREET 1:		P. O. BOX 538
		CITY:			CHARLESTON
		STATE:			SC
		ZIP:			29402

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BANK OF SOUTH CAROLINA CORP
		CENTRAL INDEX KEY:			0001007273
		STANDARD INDUSTRIAL CLASSIFICATION:	STATE COMMERCIAL BANKS [6022]
		IRS NUMBER:				571021355
		STATE OF INCORPORATION:			SC
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		256 MEETING ST
		STREET 2:		P O BOX 538
		CITY:			CHARLESTON
		STATE:			SC
		ZIP:			29402
		BUSINESS PHONE:		803 724 1500

	MAIL ADDRESS:	
		STREET 1:		256 MEETING STREET
		CITY:			CHARLESTON
		STATE:			SC
		ZIP:			29402
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-01-19</periodOfReport>

    <issuer>
        <issuerCik>0001007273</issuerCik>
        <issuerName>BANK OF SOUTH CAROLINA CORP</issuerName>
        <issuerTradingSymbol>BKSC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001478189</rptOwnerCik>
            <rptOwnerName>Sharry Sheryl G</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>P. O. BOX 538</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>CHARLESTON</rptOwnerCity>
            <rptOwnerState>SC</rptOwnerState>
            <rptOwnerZipCode>29402-0538</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>Senior Vice President</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-01-19</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>300</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>9.75</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>13062</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Unallocated Shares as a Trustee of ESOP</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>27931</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>23949.535</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By ESOP</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks>Disclaims beneficial ownership of 175,374 shares owned by the BKSC ESOP which have been allocated to members of the plan, each of whom has the right to direct the Trustees as to the manner in which voting rights are to be exercised.</remarks>

    <ownerSignature>
        <signatureName>Janice B. Stanley, Attorney in Fact</signatureName>
        <signatureDate>2010-01-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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