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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 Ui7r+X3E0HX+mVDlagNksWekBRAC+eYartUV+ffp8Vl9srpeqm+GrLYZAgnE2I85
 MR2QUeI/R6XRGHI1FDAFVw==

<SEC-DOCUMENT>0001181431-08-015637.txt : 20080304
<SEC-HEADER>0001181431-08-015637.hdr.sgml : 20080304
<ACCEPTANCE-DATETIME>20080304114856
ACCESSION NUMBER:		0001181431-08-015637
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080303
FILED AS OF DATE:		20080304
DATE AS OF CHANGE:		20080304

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Haynes Mona
		CENTRAL INDEX KEY:			0001427427

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33730
		FILM NUMBER:		08662475

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		617-577-9020

	MAIL ADDRESS:	
		STREET 1:		222 THIRD STREET, SUITE 2300
		STREET 2:		C/O TARGANTA THERAPEUTICS CORPORATION
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Targanta Therapeutics Corp.
		CENTRAL INDEX KEY:			0001398161
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				203971077
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		222 THIRD AVENUE
		STREET 2:		SUITE 2300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		(617) 557-9020

	MAIL ADDRESS:	
		STREET 1:		222 THIRD AVENUE
		STREET 2:		SUITE 2300
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>rrd195815.xml
<DESCRIPTION>HAYNES - FORM 3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-03-03</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001398161</issuerCik>
        <issuerName>Targanta Therapeutics Corp.</issuerName>
        <issuerTradingSymbol>TARG</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001427427</rptOwnerCik>
            <rptOwnerName>Haynes Mona</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TARGANTA THERAPEUTICS CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>222 THIRD STREET</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02142</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Commercial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Incentive Stock Options (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>8.68</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2018-03-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>143000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Options shall vest quarterly in arrears over four years, commencing on March 3, 2008 (such that the first 8,937 shares shall vest on June 3, 2008).</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Mona Haynes</signatureName>
        <signatureDate>2008-03-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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