-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001181431-08-068162.txt : 20081218
<SEC-HEADER>0001181431-08-068162.hdr.sgml : 20081218
<ACCEPTANCE-DATETIME>20081218151426
ACCESSION NUMBER:		0001181431-08-068162
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20081216
FILED AS OF DATE:		20081218
DATE AS OF CHANGE:		20081218

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Perkins Adelene Q
		CENTRAL INDEX KEY:			0001375124

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-31141
		FILM NUMBER:		081257334

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(617) 453-1000

	MAIL ADDRESS:	
		STREET 1:		C/O INFINITY PHARMACEUTICALS, INC.
		STREET 2:		780 MEMORIAL DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			INFINITY PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001113148
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330655706
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		780 MEMORIAL DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6174531000

	MAIL ADDRESS:	
		STREET 1:		780 MEMORIAL DRIVE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INFINITY PHARMACEUTICALS, INC./NEW/
		DATE OF NAME CHANGE:	20060913

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DISCOVERY PARTNERS INTERNATIONAL INC
		DATE OF NAME CHANGE:	20000428
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd226884.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

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    <periodOfReport>2008-12-16</periodOfReport>

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        <issuerName>INFINITY PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>INFI</issuerTradingSymbol>
    </issuer>

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            <rptOwnerName>Perkins Adelene Q</rptOwnerName>
        </reportingOwnerId>
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            <rptOwnerStreet1>C/O INFINITY PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>780 MEMORIAL DRIVE</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02139</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Pres &amp; Chief Business Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

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                <transactionPricePerShare>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
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                    <value>239</value>
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                <transactionPricePerShare>
                    <value>7.91</value>
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    <ownerSignature>
        <signatureName>/s/ Adelene Q. Perkins</signatureName>
        <signatureDate>2008-12-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----