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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001209191-08-065611.txt : 20081212
<SEC-HEADER>0001209191-08-065611.hdr.sgml : 20081212
<ACCEPTANCE-DATETIME>20081212165921
ACCESSION NUMBER:		0001209191-08-065611
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20081210
FILED AS OF DATE:		20081212
DATE AS OF CHANGE:		20081212

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Georgius John
		CENTRAL INDEX KEY:			0001342182

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32649
		FILM NUMBER:		081247479

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		704-904-2900

	MAIL ADDRESS:	
		STREET 1:		4401 BARCLAY DOWNS DRIVE
		STREET 2:		SUITE 300
		CITY:			CHARLOTTE
		STATE:			NC
		ZIP:			28209

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cogdell Spencer Inc.
		CENTRAL INDEX KEY:			0001332896
		STANDARD INDUSTRIAL CLASSIFICATION:	REAL ESTATE INVESTMENT TRUSTS [6798]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			MD
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		4401 BARCLAY DOWNS DRIVE, SUITE 300
		CITY:			CHARLOTTE
		STATE:			NC
		ZIP:			28209-4670
		BUSINESS PHONE:		704-940-2900

	MAIL ADDRESS:	
		STREET 1:		4401 BARCLAY DOWNS DRIVE, SUITE 300
		CITY:			CHARLOTTE
		STATE:			NC
		ZIP:			28209-4670
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c78309_4x0.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-12-10</periodOfReport>

    <issuer>
        <issuerCik>0001332896</issuerCik>
        <issuerName>Cogdell Spencer Inc.</issuerName>
        <issuerTradingSymbol>CSA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001342182</rptOwnerCik>
            <rptOwnerName>Georgius John</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>4401 BARCLAY DOWNS DRVIE, SUITE 300</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>CHARLOTTE</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>28209</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Cogdell Spencer Inc</value>
            </securityTitle>
            <transactionDate>
                <value>2008-12-10</value>
            </transactionDate>
            <deemedExecutionDate>
                <value>2008-12-10</value>
            </deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>20000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>9.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>49000</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>John R Georgius Rev Trust</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">In addition to the amount of securities beneficially owned following reported transaction, Mr. Georgius has 3,135 long term incentive plan units (&quot;LTIP units&quot;) pursuant to Cogdell Spencer Inc.'s (the &quot;Company'&quot;) 2005 long-term stock incentive plan.  The LTIP units are convertible into limited partnership units (&quot;OP units&quot;) in Cogdell Spencer LP (the &quot;Operating Partnership&quot;) on a one for one basis.  OP units are redeemable for a cash amount equal to the value of OP units or, in the Company's sole and absolute discretion, exchangeable for shares of the Company's common stock based on an exchange ratio of one share of common stock for one OP unit.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Charles M. Handy, Attorney-In-Fact</signatureName>
        <signatureDate>2008-12-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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