0001306923-18-000014.txt : 20180515 0001306923-18-000014.hdr.sgml : 20180515 20180515162841 ACCESSION NUMBER: 0001306923-18-000014 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20180331 FILED AS OF DATE: 20180515 DATE AS OF CHANGE: 20180515 EFFECTIVENESS DATE: 20180515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Palo Alto Investors LP CENTRAL INDEX KEY: 0001306923 IRS NUMBER: 770558164 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-11013 FILM NUMBER: 18836977 BUSINESS ADDRESS: STREET 1: 470 UNIVERSITY AVE CITY: PALO ALTO STATE: CA ZIP: 94301 BUSINESS PHONE: 650-325-0772 MAIL ADDRESS: STREET 1: 470 UNIVERSITY AVE CITY: PALO ALTO STATE: CA ZIP: 94301 FORMER COMPANY: FORMER CONFORMED NAME: Palo Alto Investors, LLC DATE OF NAME CHANGE: 20041025 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001306923 XXXXXXXX 03-31-2018 03-31-2018 false Palo Alto Investors LP

470 University Ave Palo Alto CA 94301

13F HOLDINGS REPORT 028-11013 N Angela Nguyen-Dinh 650-325-0772 /s/ Angela Nguyen-Dinh Palo Alto CA 05-15-2018 0 36 2338493 INFORMATION TABLE 2 infotable.xml ABIOMED INC COM 003654100 391865 1346660 SH SOLE 1346660 0 0 ACADIA PHARMACEUTICALS INC COM 004225108 37093 1650780 SH SOLE 1650780 0 0 AIMMUNE THERAPEUTICS INC COM 00900T107 43178 1356514 SH SOLE 1356514 0 0 ALDER BIOPHARMACEUTICALS INC COM 014339105 23493 1849832 SH SOLE 1849832 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 126601 1135845 SH SOLE 1135845 0 0 ALIGN TECHNOLOGY INC COM 016255101 54924 218707 SH SOLE 218707 0 0 ALIMERA SCIENCES INC COM 016259103 3104 3013793 SH SOLE 3013793 0 0 AMAG PHARMACEUTICALS INC COM 00163U106 67317 3340806 SH SOLE 3340806 0 0 AMICUS THERAPEUTICS INC COM 03152W109 92463 6147829 SH SOLE 6147829 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 206362 2545482 SH SOLE 2545482 0 0 CELGENE CORP COM 151020104 33823 379140 SH SOLE 379140 0 0 CLOVIS ONCOLOGY INC COM 189464100 208859 3955660 SH SOLE 3955660 0 0 CYTOKINETICS INC COM NEW 23282W605 891 123686 SH SOLE 123686 0 0 DICERNA PHARMACEUTICALS INC COM 253031108 4789 500913 SH SOLE 500913 0 0 EPIZYME INC COM 29428V104 122388 6895075 SH SOLE 6895075 0 0 EXACT SCIENCES CORP COM 30063P105 12612 312719 SH SOLE 312719 0 0 GILEAD SCIENCES INC COM 375558103 13261 175900 SH SOLE 175900 0 0 HISTOGENICS CORP COM 43358V109 833 302922 SH SOLE 302922 0 0 IDERA PHARMACEUTICALS INC COM NEW 45168K306 1134 616355 SH SOLE 616355 0 0 IMMUNOMEDICS INC COM 452907108 70070 4796008 SH SOLE 4796008 0 0 INSMED INC COM PAR $.01 457669307 161234 7159590 SH SOLE 7159590 0 0 KARYOPHARM THERAPEUTICS INC COM 48576U106 49385 3679978 SH SOLE 3679978 0 0 MELINTA THERAPEUTICS INC COM 58549G100 375 50689 SH SOLE 50689 0 0 MOMENTA PHARMACEUTICALS INC COM 60877T100 33222 1830435 SH SOLE 1830435 0 0 PROTHENA CORP PLC SHS G72800108 40430 1101338 SH SOLE 1101338 0 0 RIGEL PHARMACEUTICALS INC COM NEW 766559603 14040 3966087 SH SOLE 3966087 0 0 SAGE THERAPEUTICS INC COM 78667J108 131809 818331 SH SOLE 818331 0 0 SHIRE PLC SPONSORED ADR 82481R106 28563 191200 SH SOLE 191200 0 0 SOPHIRIS BIO INC COM NEW 83578Q209 496 247000 SH SOLE 247000 0 0 STAAR SURGICAL CO COM PAR $0.01 852312305 52028 3515385 SH SOLE 3515385 0 0 SUNESIS PHARMACEUTICALS INC COM PAR 867328700 3162 1162473 SH SOLE 1162473 0 0 TREVENA INC COM 89532E109 560 341300 SH SOLE 341300 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 182319 1622631 SH SOLE 1622631 0 0 VANDA PHARMACEUTICALS INC COM 921659108 70023 4155670 SH SOLE 4155670 0 0 WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 54606 2752294 SH SOLE 2752294 0 0 ZOGENIX INC COM NEW 98978L204 1181 29500 SH SOLE 29500 0 0