SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Skyline Venture Partners V LP (Last) (First) (Middle) 525 UNIVERSITY AVE. (Street) PALO ALTO CA 94301 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 10/28/2008	3. Issuer Name and Ticker or Trading Symbol MAKO Surgical Corp. [ MAKO ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	2,437,249	I	By Skyline Venture Partners V, L.P.(1)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Warrant to Purchase Common Stock	10/28/2008	10/28/2015	Common Stock	487,450	$7.44	I	By Skyline Venture Partners V, L.P.(2)

1. Name and Address of Reporting Person* Skyline Venture Partners V LP (Last) (First) (Middle) 525 UNIVERSITY AVE. (Street) PALO ALTO CA 94301 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Skyline Venture Management V, LLC (Last) (First) (Middle) 525 UNIVERSITY AVE. (Street) PALO ALTO CA 94301 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Freund John Gordon (Last) (First) (Middle) 525 UNIVERSITY AVE. (Street) PALO ALTO CA 94301 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

Explanation of Responses:

1. The shares are owned by Skyline Venture Partners V, L.P. ("SVP V"). Skyline Venture Management V, LLC ("SVM V") serves as the sole General Partner of SVP V, has sole voting and investment control over the respective shares owned by SVP V, and may be deemed to own beneficially the shares held by SVP V. SVM V however owns no securities of the Issuer directly. John G. Freund ("Freund") is the sole Managing Director of SVM V and has voting and dispositive power over the shares held by SVP V. Freund disclaims beneficial ownership of the shares reported herein, except to the extent of his respective pecuniary interest therein.

2. The warrant is held by SVP V.

	SKYLINE VENTURE PARTNERS V, L.P. By: SKYLINE VENTURE MANAGEMENT V, LLC Its: General Partner By: John G. Freund, Managing Director	02/27/2009
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
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